Neoadjuvant intraperitoneal chemotherapy for advanced stage gastric cancer (Review)

  • Authors:
    • Nicolae Bacalbasa
    • Camelia Diaconu
    • Bogdan Socea
    • Florentina Gherghiceanu
    • Cornel Savu
    • Mihai Dimitriu
    • Irina Balescu
    • Ioan Cordos
  • View Affiliations

  • Published online on: September 17, 2021     https://doi.org/10.3892/etm.2021.10749
  • Article Number: 1314
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Abstract

Gastric cancer remains one of the most lethal malignancies especially when diagnosed in advanced stages of the disease; most often patients diagnosed later during the progression of their disease will present a certain degree of peritoneal contamination such as positive peritoneal cytology or peritoneal metastatic nodules. In such cases most often they then progress to peritoneal carcinomatosis and succumb to the disease within one year. In order to increase the lifespan in such cases multiple therapeutic strategies have been proposed such as radical surgery and intraperitoneal heated chemotherapy or direct intraperitoneal chemotherapy followed by radical surgery. To date, the benefits of intraperitoneal heated chemotherapy at the time of resection have been widely investigated; however the method is still associated with increased rates of perioperative complications. Therefore, attention was focused on investigating the benefits of such procedures as neoadjuvant therapies followed by radical surgery. The aim of the present review was to examine the most efficient therapeutic strategies in advanced‑stage gastric cancer such as neoadjuvant laparoscopic heated intraperitoneal chemotherapy, perioperative heated intraperitoneal chemotherapy and neoadjuvant systemic and peritoneal chemotherapy.
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November-2021
Volume 22 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Bacalbasa N, Diaconu C, Socea B, Gherghiceanu F, Savu C, Dimitriu M, Balescu I and Cordos I: Neoadjuvant intraperitoneal chemotherapy for advanced stage gastric cancer (Review). Exp Ther Med 22: 1314, 2021.
APA
Bacalbasa, N., Diaconu, C., Socea, B., Gherghiceanu, F., Savu, C., Dimitriu, M. ... Cordos, I. (2021). Neoadjuvant intraperitoneal chemotherapy for advanced stage gastric cancer (Review). Experimental and Therapeutic Medicine, 22, 1314. https://doi.org/10.3892/etm.2021.10749
MLA
Bacalbasa, N., Diaconu, C., Socea, B., Gherghiceanu, F., Savu, C., Dimitriu, M., Balescu, I., Cordos, I."Neoadjuvant intraperitoneal chemotherapy for advanced stage gastric cancer (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1314.
Chicago
Bacalbasa, N., Diaconu, C., Socea, B., Gherghiceanu, F., Savu, C., Dimitriu, M., Balescu, I., Cordos, I."Neoadjuvant intraperitoneal chemotherapy for advanced stage gastric cancer (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1314. https://doi.org/10.3892/etm.2021.10749