Animal models of dry eye disease: Useful, varied and evolving (Review)
- Authors:
- Wei Huang
- Konstantinos Tourmouzis
- Henry Perry
- Robert A. Honkanen
- Basil Rigas
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Affiliations: Department of Ophthalmology, Stony Brook University, Stony Brook, NY 11794, USA, Barts and The London School of Medicine and Dentistry, E1 2AD London, UK, Ophthalomology Consultants of Long Island, Westbury, NY 11590, USA, Department of Preventive Medicine, Stony Brook University, Stony Brook, NY 11794, USA - Published online on: October 1, 2021 https://doi.org/10.3892/etm.2021.10830
- Article Number: 1394
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Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
The definition and classification of dry eye disease. Report of the definition and classification subcommittee of the international dry eye workshop (2007). Ocul Surf. 5:75–92. 2007.PubMed/NCBI View Article : Google Scholar | |
Takamiya M, Weger BD, Schindler S, Beil T, Yang L, Armant O, Ferg M, Schlunck G, Reinhard T, Dickmeis T, et al: Molecular description of eye defects in the zebrafish Pax6b mutant, sunrise, reveals a Pax6b-dependent genetic network in the developing anterior chamber. PLoS One. 10(e0117645)2015.PubMed/NCBI View Article : Google Scholar | |
Baldassano VF Jr: Ocular manifestations of rheumatic diseases. Curr Opin Ophthalmol. 9:85–88. 1998.PubMed/NCBI View Article : Google Scholar | |
Kemeny-Beke A and Szodoray P: Ocular manifestations of rheumatic diseases. Int Ophthalmol. 40:503–510. 2020.PubMed/NCBI View Article : Google Scholar | |
Zoukhri D and Kublin CL: Impaired neurotransmitter release from lacrimal and salivary gland nerves of a murine model of Sjögren's syndrome. Invest Ophthalmol Vis Sci. 42:925–932. 2001.PubMed/NCBI | |
Toda I, Sullivan BD, Wickham LA and Sullivan DA: Gender- and androgen-related influence on the expression of proto-oncogene and apoptotic factor mRNAs in lacrimal glands of autoimmune and non-autoimmune mice. J Steroid Biochem Mol Biol. 71:49–61. 1999.PubMed/NCBI View Article : Google Scholar | |
Schrader S, Mircheff AK and Geerling G: Animal models of dry eye. Dev Ophthalmol. 41:298–312. 2008.PubMed/NCBI View Article : Google Scholar | |
Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA and Nagata S: Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature. 356:314–317. 1992.PubMed/NCBI View Article : Google Scholar | |
Singer GG and Abbas AK: The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity. 1:365–371. 1994.PubMed/NCBI View Article : Google Scholar | |
Törnwall J, Lane TE, Fox RI and Fox HS: T cell attractant chemokine expression initiates lacrimal gland destruction in nonobese diabetic mice. Lab Invest. 79:1719–1726. 1999.PubMed/NCBI | |
Robinson CP, Cornelius J, Bounous DE, Yamamoto H, Humphreys-Beher MG and Peck AB: Characterization of the changing lymphocyte populations and cytokine expression in the exocrine tissues of autoimmune NOD mice. Autoimmunity. 27:29–44. 1998.PubMed/NCBI View Article : Google Scholar | |
Yamamoto H, Sims NE, Macauley SP, Nguyen KH, Nakagawa Y and HumphreysBeher MG: Alterations in the secretory response of non-obese diabetic (NOD) mice to muscarinic receptor stimulation. Clin Immunol Immunop. 78:245–255. 1996.PubMed/NCBI View Article : Google Scholar | |
Coursey TG, Bian F, Zaheer M, Pflugfelder SC, Volpe EA and de Paiva CS: Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells. Mucosal Immunol. 10:743–756. 2017.PubMed/NCBI View Article : Google Scholar | |
Takahashi M, Ishimaru N, Yanagi K, Haneji N, Saito I and Hayashi Y: High incidence of autoimmune dacryoadenitis in male non-obese diabetic (NOD) mice depending on sex steroid. Clin Exp Immunol. 109:555–561. 1997.PubMed/NCBI View Article : Google Scholar | |
Vendramini ACL, Soo C and Sullivan DA: Testosterone-induced suppression of autoimmune disease in lacrimal tissue of a mouse model (NZB/NZW F1) of Sjögren's syndrome. Invest Ophthalmol Vis Sci. 32:3002–3006. 1991.PubMed/NCBI | |
Sullivan DA and Edwards JA: Androgen stimulation of lacrimal gland function in mouse models of Sjögren's syndrome. J Steroid Biochem. 60:237–245. 1997.PubMed/NCBI View Article : Google Scholar | |
Haneji N, Nakamura T, Takio K, Yanagi K, Higashiyama H, Saito I, Noji S, Sugino H and Hayashi Y: Identification of alpha-fodrin as a candidate autoantigen in primary Sjögren's syndrome. Science. 276:604–607. 1997.PubMed/NCBI View Article : Google Scholar | |
Song XJ, Li DQ, Farley W, Luo LH, Heuckeroth RO, Milbrandt J and Pflugfelder SC: Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 44:4223–4229. 2003.PubMed/NCBI View Article : Google Scholar | |
McCartney-Francis NL, Mizel DE, Frazier-Jessen M, Kulkarni AB, McCarthy JB and Wahl SM: Lacrimal gland inflammation is responsible for ocular pathology in TGF-beta 1 null mice. Am J Pathol. 151:1281–1288. 1997.PubMed/NCBI | |
McCartney-Francis NL, Mizel DE, Redman RS, Frazier-Jessen M, Panek RB, Kulkarni AB, Ward JM, McCarthy JB and Wahl SM: Autoimmune Sjögren's-like lesions in salivary glands of TGF-beta1-deficient mice are inhibited by adhesion-blocking peptides. J Immunol. 157:1306–1312. 1996.PubMed/NCBI | |
Konno A, Takada K, Saegusa J and Takiguchi M: Presence of B7-2+ dendritic cells and expression of Th1 cytokines in the early development of sialodacryoadenitis in the IqI/Jic mouse model of primary Sjörgren's syndrome. Autoimmunity. 36:247–254. 2003.PubMed/NCBI View Article : Google Scholar | |
Li H, Dai M and Zhuang Y: A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. Immunity. 21:551–560. 2004.PubMed/NCBI View Article : Google Scholar | |
Shinomiya K, Ueta M and Kinoshita S: A new dry eye mouse model produced by exorbital and intraorbital lacrimal gland excision. Sci Rep. 8(1483)2018.PubMed/NCBI View Article : Google Scholar | |
Nakamura T, Hata Y, Nagata M, Yokoi N, Yamaguchi S, Kaku T and Kinoshita S: JBP485 promotes tear and mucin secretion in ocular surface epithelia. Sci Rep. 5(10248)2015.PubMed/NCBI View Article : Google Scholar | |
Bron AJ, de Paiva CS, Chauhan SK, Bonini S, Gabison EE, Jain S, Knop E, Markoulli M, Ogawa Y, Perez V, et al: TFOS DEWS II pathophysiology report. Ocul Surf. 15:438–510. 2017.PubMed/NCBI View Article : Google Scholar | |
Dursun D, Wang M, Monroy D, Li DQ, Lokeshwar BL, Stern ME and Pflugfelder SC: A mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 43:632–638. 2002.PubMed/NCBI | |
Sano K, Kawashima M, Imada T, Suzuki T, Nakamura S, Mimura M, Tanaka KF and Tsubota K: Enriched environment alleviates stress-induced dry-eye through the BDNF axis. Sci Rep. 9(3422)2019.PubMed/NCBI View Article : Google Scholar | |
Stewart P, Chen Z, Farley W, Olmos L and Pflugfelder SC: Effect of experimental dry eye on tear sodium concentration in the mouse. Eye Contact Lens. 31:175–178. 2005.PubMed/NCBI View Article : Google Scholar | |
Yeh S, Song XJ, Farley W, Li DQ, Stern ME and Pflugfelder SC: Apoptosis of ocular surface cells in experimentally induced dry eye. Invest Ophthalmol Vis Sci. 44:124–129. 2003.PubMed/NCBI View Article : Google Scholar | |
Niederkorn JY, Stern ME, Pflugfelder SC, De Paiva CS, Corrales RM, Gao J and Siemasko K: Desiccating stress induces T cell-mediated Sjögren's syndrome-like lacrimal keratoconjunctivitis. J Immunol. 176:3950–3957. 2006.PubMed/NCBI View Article : Google Scholar | |
Barabino S, Shen L, Chen L, Rashid S, Rolando M and Dana MR: The controlled-environment chamber: A new mouse model of dry eye. Invest Ophthalmol Vis Sci. 46:2766–2771. 2005.PubMed/NCBI View Article : Google Scholar | |
De Paiva CS, Corrales RM, Villarreal AL, Farley WJ, Li DQ, Stern ME and Pflugfelder SC: Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye. Exp Eye Res. 83:526–535. 2006.PubMed/NCBI View Article : Google Scholar | |
Corrales RM, de Paiva CS, Li DQ, Farley WJ, Henriksson JT, Bergmanson JP and Pflugfelder SC: Entrapment of conjunctival goblet cells by desiccation-induced cornification. Invest Ophthalmol Vis Sci. 52:3492–3499. 2011.PubMed/NCBI View Article : Google Scholar | |
De Paiva CS, Yoon KC, Pangelinan SB, Pham S, Puthenparambil LM, Chuang EY, Farley WJ, Stern ME, Li DQ and Pflugfelder SC: Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9. J Inflamm (Lond). 6(31)2009.PubMed/NCBI View Article : Google Scholar | |
Coursey TG, Tukler Henriksson J, Barbosa FL, de Paiva CS and Pflugfelder SC: Interferon-γ-induced unfolded protein response in conjunctival goblet cells as a cause of mucin deficiency in Sjögren syndrome. Am J Pathol. 186:1547–1558. 2016.PubMed/NCBI View Article : Google Scholar | |
Chen Y, Zhang X, Yang L, Li M, Li B, Wang W and Sheng M: Decreased PPAR-γ expression in the conjunctiva and increased expression of TNF-α and IL-1β in the conjunctiva and tear fluid of dry eye mice. Mol Med Rep. 9:2015–2023. 2014.PubMed/NCBI View Article : Google Scholar | |
Chen Y, Chauhan SK, Lee HS, Stevenson W, Schaumburg CS, Sadrai Z, Saban DR, Kodati S, Stern ME and Dana R: Effect of desiccating environmental stress versus systemic muscarinic AChR blockade on dry eye immunopathogenesis. Invest Ophthalmol Vis Sci. 54:2457–2464. 2013.PubMed/NCBI View Article : Google Scholar | |
Schein OD, Muñoz B, Tielsch JM, Bandeen-Roche K and West S: Prevalence of dry eye among the elderly. Am J Ophthalmol. 124:723–728. 1997.PubMed/NCBI View Article : Google Scholar | |
Moss SE, Klein R and Klein BE: Incidence of dry eye in an older population. Arch Ophthalmol. 122:369–373. 2004.PubMed/NCBI View Article : Google Scholar | |
McClellan AJ, Volpe EA, Zhang X, Darlington GJ, Li DQ, Pflugfelder SC and de Paiva CS: Ocular surface disease and dacryoadenitis in aging C57BL/6 mice. Am J Pathol. 184:631–643. 2014.PubMed/NCBI View Article : Google Scholar | |
de Paiva CS: Effects of aging in dry eye. Int Ophthalmol Clin. 57:47–64. 2017.PubMed/NCBI View Article : Google Scholar | |
Ding J and Sullivan DA: Aging and dry eye disease. Exp Gerontol. 47:483–490. 2012.PubMed/NCBI View Article : Google Scholar | |
Jester BE, Nien CJ, Winkler M, Brown DJ and Jester JV: Volumetric reconstruction of the mouse meibomian gland using high-resolution nonlinear optical imaging. Anat Rec (Hoboken). 294:185–192. 2011.PubMed/NCBI View Article : Google Scholar | |
Nien CJ, Paugh JR, Massei S, Wahlert AJ, Kao WW and Jester JV: Age-related changes in the meibomian gland. Exp Eye Res. 89:1021–1027. 2009.PubMed/NCBI View Article : Google Scholar | |
Parfitt GJ, Xie Y, Geyfman M, Brown DJ and Jester JV: Absence of ductal hyper-keratinization in mouse age-related meibomian gland dysfunction (ARMGD). Aging (Albany NY). 5:825–834. 2013.PubMed/NCBI View Article : Google Scholar | |
Ru Y, Huang Y, Liu H, Du J, Meng Z, Dou Z, Liu X, Wei RH, Zhang Y and Zhao S: α-Melanocyte-stimulating hormone ameliorates ocular surface dysfunctions and lesions in a scopolamine-induced dry eye model via PKA-CREB and MEK-Erk pathways. Sci Rep. 5(18619)2015.PubMed/NCBI View Article : Google Scholar | |
Chen W, Zhao K, Li X and Yoshitomi T: Keratoconjunctivitis sicca modifies epithelial stem cell proliferation kinetics in conjunctiva. Cornea. 26:1101–1106. 2007.PubMed/NCBI View Article : Google Scholar | |
Viau S, Maire MA, Pasquis B, Grégoire S, Fourgeux C, Acar N, Bretillon L, Creuzot-Garcher CP and Joffre C: Time course of ocular surface and lacrimal gland changes in a new scopolamine-induced dry eye model. Graefes Arch Clin Exp Ophthalmol. 246:857–867. 2008.PubMed/NCBI View Article : Google Scholar | |
Viau S, Maire MA, Pasquis B, Grégoire S, Acar N, Bron AM, Bretillon L, Creuzot-Garcher CP and Joffre C: Efficacy of a 2-month dietary supplementation with polyunsaturated fatty acids in dry eye induced by scopolamine in a rat model. Graefes Arch Clin Exp Ophthalmol. 247:1039–1050. 2009.PubMed/NCBI View Article : Google Scholar | |
Nakaishi H and Yamada Y: Abnormal tear dynamics and symptoms of eyestrain in operators of visual display terminals. Occup Environ Med. 56:6–9. 1999.PubMed/NCBI View Article : Google Scholar | |
Uchino M, Kawashima M, Uchino Y, Tsubota K and Yokoi N: Association between tear film break up time and blink interval in visual display terminal users. Int J Ophthalmol. 11:1691–1697. 2018.PubMed/NCBI View Article : Google Scholar | |
Nakamura S, Kinoshita S, Yokoi N, Ogawa Y, Shibuya M, Nakashima H, Hisamura R, Imada T, Imagawa T, Uehara M, et al: Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users. PLoS One. 5(e11119)2010.PubMed/NCBI View Article : Google Scholar | |
Nakamura S, Shibuya M, Nakashima H, Imagawa T, Uehara M and Tsubota K: D-beta-hydroxybutyrate protects against corneal epithelial disorders in a rat dry eye model with jogging board. Invest Ophthalmol Vis Sci. 46:2379–2387. 2005.PubMed/NCBI View Article : Google Scholar | |
Imada T, Nakamura S, Kitamura N, Shibuya I and Tsubota K: Oral administration of royal jelly restores tear secretion capacity in rat blink-suppressed dry eye model by modulating lacrimal gland function. PLoS One. 9(e106338)2014.PubMed/NCBI View Article : Google Scholar | |
Xiao F, Cui H and Zhong X: Beneficial effect of daidzin in dry eye rat model through the suppression of inflammation and oxidative stress in the cornea. Saudi J Biol Sci. 25:832–837. 2018.PubMed/NCBI View Article : Google Scholar | |
Meng ID, Barton ST, Mecum NE and Kurose M: Corneal sensitivity following lacrimal gland excision in the rat. Invest Ophthalmol Vis Sci. 56:3347–3354. 2015.PubMed/NCBI View Article : Google Scholar | |
Park B, Jo K, Lee TG, Lee IS, Kim JS and Kim CS: Polygonum cuspidatum stem extract (PSE) ameliorates dry eye disease by inhibiting inflammation and apoptosis. J Exerc Nutrition Biochem. 23:14–22. 2019.PubMed/NCBI View Article : Google Scholar | |
Peng QH, Yao XL, Wu QL, Tan HY and Zhang JR: Effects of extract of Buddleja officinalis eye drops on androgen receptors of lacrimal gland cells of castrated rats with dry eye. Int J Ophthalmol. 3:43–48. 2010.PubMed/NCBI View Article : Google Scholar | |
Li L, Jin D, Gao J, Wang L, Liu X, Wang J and Xu Z: Activities of autonomic neurotransmitters in meibomian gland tissues are associated with menopausal dry eye. Neural Regen Res. 7:2761–2769. 2012.PubMed/NCBI View Article : Google Scholar | |
Liu SH, Sakai F, Prendergast RA and Silverstein AM: Experimental autoimmune dacryoadenitis. II. Harderian gland disease in the rat. Invest Ophthalmol Vis Sci. 28:276–280. 1987.PubMed/NCBI | |
Hou A, Bose T, Chandy KG and Tong L: A chronic autoimmune dry eye rat model with increase in effector memory T cells in eyeball tissue. J Vis Exp. (55592)2017.PubMed/NCBI View Article : Google Scholar | |
Zhang FD, Hao ZQ, Gao W and Xing YQ: Effect of topical 0.05% cyclosporine A on the tear protein lacritin in a rat model of dry eye. Int J Ophthalmol. 12:189–193. 2019.PubMed/NCBI View Article : Google Scholar | |
Higuchi A, Inoue H, Kaneko Y, Oonishi E and Tsubota K: Selenium-binding lactoferrin is taken into corneal epithelial cells by a receptor and prevents corneal damage in dry eye model animals. Sci Rep. 6(36903)2016.PubMed/NCBI View Article : Google Scholar | |
Lee TG, Hyun SW, Jo K, Park B, Lee IS, Song SJ and Kim CS: Achyranthis radix extract improves urban particulate matter-induced dry eye disease. Int J Environ Res Public Health. 16(3229)2019.PubMed/NCBI View Article : Google Scholar | |
Schechter JE, Warren DW and Mircheff AK: A lacrimal gland is a lacrimal gland, but rodent's and rabbit's are not human. Ocul Surf. 8:111–134. 2010.PubMed/NCBI View Article : Google Scholar | |
Chen ZY, Liang QF and Yu GY: Establishment of a rabbit model for keratoconjunctivitis sicca. Cornea. 30:1024–1029. 2011.PubMed/NCBI View Article : Google Scholar | |
Gilbard JP, Rossi SR and Gray KL: A new rabbit model for keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 28:225–228. 1987.PubMed/NCBI | |
Beutel J, Schroder C, von Hof K, Rades D, Kosmehl H, Wedel T, Sieg P, Geerling G and Hakim SG: Pharmacological prevention of radiation-induced dry eye-an experimental study in a rabbit model. Graefes Arch Clin Exp Ophthalmol. 245:1347–1355. 2007.PubMed/NCBI View Article : Google Scholar | |
Guo Z, Song D, Azzarolo AM, Schechter JE, Warren DW, Wood RL, Mircheff AK and Kaslow HR: Autologous lacrimal-lymphoid mixed-cell reactions induce dacryoadenitis in rabbits. Exp Eye Res. 71:23–31. 2000.PubMed/NCBI View Article : Google Scholar | |
Nagelhout TJ, Gamache DA, Roberts L, Brady MT and Yanni JM: Preservation of tear film integrity and inhibition of corneal injury by dexamethasone in a rabbit model of lacrimal gland inflammation-induced dry eye. J Ocul Pharmacol Ther. 21:139–148. 2005.PubMed/NCBI View Article : Google Scholar | |
Honkanen RA, Huang L, Xie G and Rigas B: Phosphosulindac is efficacious in an improved concanavalin A-based rabbit model of chronic dry eye disease. Transl Res. 198:58–72. 2018.PubMed/NCBI View Article : Google Scholar | |
Demetriades AM, Leyngold IM, D'Anna S, Eghrari AO, Emmert DG, Grant MP and Merbs SL: Intraglandular injection of botulinum toxin a reduces tear production in rabbits. Ophthalmic Plast Reconstr Surg. 29:21–24. 2013.PubMed/NCBI View Article : Google Scholar | |
Toshida H, Nguyen DH, Beuerman RW and Murakami A: Evaluation of novel dry eye model: Preganglionic parasympathetic denervation in rabbit. Invest Ophthalmol Vis Sci. 48:4468–4475. 2007.PubMed/NCBI View Article : Google Scholar | |
Burgalassi S, Panichi L, Chetoni P, Saettone MF and Boldrini E: Development of a simple dry eye model in the albino rabbit and evaluation of some tear substitutes. Ophthalmic Res. 31:229–235. 1999.PubMed/NCBI View Article : Google Scholar | |
Xiong C, Chen D, Liu J, Liu B, Li N, Zhou Y, Liang X, Ma P, Ye C, Ge J and Wang Z: A rabbit dry eye model induced by topical medication of a preservative benzalkonium chloride. Invest Ophthalmol Vis Sci. 49:1850–1856. 2008.PubMed/NCBI View Article : Google Scholar | |
Gilbard JP, Rossi SR and Heyda KG: Tear film and ocular surface changes after closure of the meibomian gland orifices in the rabbit. Ophthalmology. 96:1180–1186. 1989.PubMed/NCBI View Article : Google Scholar | |
Fujihara T, Nagano T, Nakamura M and Shirasawa E: Establishment of a rabbit short-term dry eye model. J Ocul Pharmacol Ther. 11:503–508. 1995.PubMed/NCBI View Article : Google Scholar | |
Yao XL, Peng QH, Peng J, Tan HY, Wu QL, Wu DL, Chen M, Li CK, Li D and Zhu HA: Effects of extract of Buddleja officinalis on partial inflammation of lacrimal gland in castrated rabbits with dry eye. Int J Ophthalmol. 3:114–119. 2010.PubMed/NCBI View Article : Google Scholar | |
Karn PR, Kim HD, Kang H, Sun BK, Jin SE and Hwang SJ: Supercritical fluid-mediated liposomes containing cyclosporin A for the treatment of dry eye syndrome in a rabbit model: Comparative study with the conventional cyclosporin A emulsion. Int J Nanomedicine. 9:3791–3800. 2014.PubMed/NCBI View Article : Google Scholar | |
Bucolo C, Fidilio A, Fresta CG, Lazzara F, Platania CBM, Cantarella G, Di Benedetto G, Burgaletto C, Bernardini R, Piazza C, et al: Ocular pharmacological profile of hydrocortisone in dry eye disease. Front Pharmacol. 10(1240)2019.PubMed/NCBI View Article : Google Scholar | |
Tampucci S, Monti D, Burgalassi S, Terreni E, Zucchetti E, Baldacci F and Chetoni P: Effect of 5-Oxo-2-pyrrolidinecarboxylic Acid (PCA) as a new topically applied agent for dry eye syndrome treatment. Pharmaceutics. 10(137)2018.PubMed/NCBI View Article : Google Scholar | |
Chen HC, Chen ZY, Wang TJ, Drew VJ, Tseng CL, Fang HW and Lin FH: Herbal supplement in a buffer for dry eye syndrome treatment. Int J Mol Sci. 18(1697)2017.PubMed/NCBI View Article : Google Scholar | |
Huang HY, Wang MC, Chen ZY, Chiu WY, Chen KH, Lin IC, Yang WV, Wu CC and Tseng CL: Gelatin-epigallocatechin gallate nanoparticles with hyaluronic acid decoration as eye drops can treat rabbit dry-eye syndrome effectively via inflammatory relief. Int J Nanomedicine. 13:7251–7273. 2018.PubMed/NCBI View Article : Google Scholar | |
Zhou L, Wei R, Zhao P, Koh SK, Beuerman RW and Ding C: Proteomic analysis revealed the altered tear protein profile in a rabbit model of Sjögren's syndrome-associated dry eye. Proteomics. 13:2469–2481. 2013.PubMed/NCBI View Article : Google Scholar | |
Bhattacharya D, Ning Y, Zhao F, Stevenson W, Chen R, Zhang J and Wang M: Tear production after bilateral main lacrimal gland resection in rabbits. Invest Ophthalmol Vis Sci. 56:7774–7783. 2015.PubMed/NCBI View Article : Google Scholar | |
Ning Y, Bhattacharya D, Jones RE, Zhao F, Chen R, Zhang J and Wang M: Evaluating the functionality of conjunctiva using a rabbit dry eye model. J Ophthalmol. 2016(3964642)2016.PubMed/NCBI View Article : Google Scholar | |
Li N, Deng X, Gao Y, Zhang S, He M and Zhao D: Establishment of the mild, moderate and severe dry eye models using three methods in rabbits. BMC Ophthalmol. 13(50)2013.PubMed/NCBI View Article : Google Scholar | |
Gilbard JP, Rossi SR, Gray KL, Hanninen LA and Kenyon KR: Tear film osmolarity and ocular surface disease in two rabbit models for keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 29:374–378. 1988.PubMed/NCBI | |
Odaka A, Toshida H, Ohta T, Tabuchi N, Koike D, Suto C and Murakami A: Efficacy of retinol palmitate eye drops for dry eye in rabbits with lacrimal gland resection. Clin Ophthalmol. 6:1585–1593. 2012.PubMed/NCBI View Article : Google Scholar | |
Honkanen RA, Huang W, Huang L, Kaplowitz K, Weissbart S and Rigas B: A new rabbit model of chronic dry eye disease induced by complete surgical dacryoadenectomy. Curr Eye Res. 44:863–872. 2019.PubMed/NCBI View Article : Google Scholar | |
Honkanen RA, Huang L and Rigas B: A rabbit model of aqueous-deficient dry eye disease induced by concanavalin A injection into the lacrimal glands: Application to drug efficacy studies. J Vis Exp, 2020. | |
Miyake H, Oda T, Katsuta O, Seno M and Nakamura M: A novel model of meibomian gland dysfunction induced with complete freund's adjuvant in rabbits. Vision (Basel). 1(10)2017.PubMed/NCBI View Article : Google Scholar | |
Niamprem P, Teapavarapruk P, Srinivas SP and Tiyaboonchai W: Impact of nanostructured lipid carriers as an artificial tear film in a rabbit evaporative dry eye model. Cornea. 38:485–491. 2019.PubMed/NCBI View Article : Google Scholar | |
Sher I, Tzameret A, Szalapak AM, Carmeli T, Derazne E, Avni-Zauberman N, Marcovich AL, Simon GB and Rotenstreich Y: Multimodal assessment of corneal erosions using optical coherence tomography and automated grading of fluorescein staining in a rabbit dry eye model. Transl Vis Sci Technol. 8(27)2019.PubMed/NCBI View Article : Google Scholar | |
Eom Y, Han JY, Kang B, Hwang HS, Lee HK, Kim HM and Song JS: Meibomian glands and ocular surface changes after closure of meibomian gland orifices in rabbits. Cornea. 37:218–226. 2018.PubMed/NCBI View Article : Google Scholar | |
Lambert RW and Smith RE: Pathogenesis of blepharoconjunctivitis complicating 13-cis-retinoic acid (isotretinoin) therapy in a laboratory model. Invest Ophthalmol Vis Sci. 29:1559–1564. 1988.PubMed/NCBI | |
Jester JV, Nicolaides N, Kiss-Palvolgyi I and Smith RE: Meibomian gland dysfunction. II. The role of keratinization in a rabbit model of MGD. Invest Ophthalmol Vis Sci. 30:936–945. 1989.PubMed/NCBI | |
Jester JV, Rife L, Nii D, Luttrull JK, Wilson L and Smith RE: In vivo biomicroscopy and photography of meibomian glands in a rabbit model of meibomian gland dysfunction. Invest Ophthalmol Vis Sci. 22:660–667. 1982.PubMed/NCBI | |
Lambert R and Smith RE: Hyperkeratinization in a rabbit model of meibomian gland dysfunction. Am J Ophthalmol. 105:703–705. 1988.PubMed/NCBI View Article : Google Scholar | |
Knop E, Knop N, Millar T, Obata H and Sullivan DA: The international workshop on meibomian gland dysfunction: Report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland. Invest Ophthalmol Vis Sci. 52:1938–1978. 2011.PubMed/NCBI View Article : Google Scholar | |
Qin G, Zhou Y, Peng J, Zhang Y, Peng X, Peng Q and Yang Y: The effect of Buddleja officinalis maxim eye drops on morphology and apoptosis in lacrimal gland of experimental dry eye rabbit model. J Ophthalmol. 2019(5916243)2019.PubMed/NCBI View Article : Google Scholar | |
Ma M, Yuan Q, Ye L, Liu K, Ye L, Min YL, Jiang N, Li Q, Shi W, Xu X, et al: An experimental study of amniotic lacrimal duct stents in the treatment of perimenopausal female rabbits with dry eye. Mol Med Rep. 19:1056–1064. 2019.PubMed/NCBI View Article : Google Scholar | |
Barabino S and Dana MR: Animal models of dry eye: A critical assessment of opportunities and limitations. Invest Ophthalmol Vis Sci. 45:1641–1646. 2004.PubMed/NCBI View Article : Google Scholar | |
McLaughlin SA, Brightman AH II, Helper LC, Primm ND, Brown MG and Greeley S: Effect of removal of lacrimal and third eyelid glands on Schirmer tear test results in cats. J Am Vet Med Assoc. 193:820–822. 1988.PubMed/NCBI | |
Dota A, Takaoka-Shichijo Y and Nakamura M: Gefarnate stimulates mucin-like glycoprotein secretion in conjunctival tissue and ameliorates corneal epithelial damage in animal dry-eye models. Clin Ophthalmol. 7:211–217. 2013.PubMed/NCBI View Article : Google Scholar | |
Quimby FW, Schwartz RS, Poskitt T and Lewis RM: A disorder of dogs resembling Sjögren's syndrome. Clin Immunol Immunopathol. 12:471–476. 1979.PubMed/NCBI View Article : Google Scholar | |
Kaswan RL, Martin CL and Chapman WL Jr: Keratoconjunctivitis sicca: Histopathologic study of nictitating membrane and lacrimal glands from 28 dogs. Am J Vet Res. 45:112–118. 1984.PubMed/NCBI | |
Kaswan RL, Martin CL and Dawe DL: Keratoconjunctivitis sicca: Immunological evaluation of 62 canine cases. Am J Vet Res. 46:376–383. 1985.PubMed/NCBI | |
Kaswan R, Pappas C Jr, Wall K and Hirsh SG: Survey of canine tear deficiency in veterinary practice. Adv Exp Med Biol. 438:931–939. 1998.PubMed/NCBI View Article : Google Scholar | |
Gao J, Schwalb TA, Addeo JV, Ghosn CR and Stern ME: The role of apoptosis in the pathogenesis of canine keratoconjunctivitis sicca: The effect of topical cyclosporin A therapy. Cornea. 17:654–663. 1998.PubMed/NCBI View Article : Google Scholar | |
Helper LC, Magrane WG, Koehm J and Johnson R: Surgical induction of keratoconjunctivitis sicca in the dog. J Am Vet Med Assoc. 165:172–174. 1974.PubMed/NCBI | |
Moore CP, McHugh JB, Thorne JG and Phillips TE: Effect of cyclosporine on conjunctival mucin in a canine keratoconjunctivitis sicca model. Invest Ophthalmol Vis Sci. 42:653–659. 2001.PubMed/NCBI | |
Maitchouk DY, Beuerman RW, Ohta T, Stern M and Varnell RJ: Tear production after unilateral removal of the main lacrimal gland in squirrel monkeys. Arch Ophthalmol. 118:246–252. 2000.PubMed/NCBI View Article : Google Scholar | |
Qin Y, Tan X, Zhang Y, Jie Y, Labbe A and Pan Z: A new nonhuman primate model of severe dry eye. Cornea. 33:510–517. 2014.PubMed/NCBI View Article : Google Scholar | |
Wong CC, Cheng KW, Xie G, Zhou D, Zhu CH, Constantinides PP and Rigas B: Carboxylesterases 1 and 2 hydrolyze phospho-nonsteroidal anti-inflammatory drugs: Relevance to their pharmacological activity. J Pharmacol Exp Ther. 340:422–432. 2012.PubMed/NCBI View Article : Google Scholar |