Influence of pemphigoid gestationis on pregnancy outcome: A case report and review of the literature

Parfene,Caliopia Gavril; Bohiltea,Roxana Elena; Mihai,Bianca Margareta; Grigoriu,Corina; Margaritescu,Irina; Chirita,Aurel Doru; Zugravu,Corina Aurelia; Pelinescu‑Onciul,Dimitrie

doi:10.3892/etm.2021.10945

Influence of pemphigoid gestationis on pregnancy outcome: A case report and review of the literature

Authors:
- Caliopia Gavril Parfene
- Roxana Elena Bohiltea
- Bianca Margareta Mihai
- Corina Grigoriu
- Irina Margaritescu
- Aurel Doru Chirita
- Corina Aurelia Zugravu
- Dimitrie Pelinescu‑Onciul
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Affiliations: Department of Obstetrics and Gynecology, Life Memorial Hospital, 012244 Bucharest, Romania, Department of Obstetrics and Gynecology, University Emergency Hospital Bucharest, 050098 Bucharest, Romania, Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Pathology, Onco Team Diagnostic, 030138 Bucharest, Romania, Department of Dermatology, ‘Carol Davila’ Central Military University Emergency Hospital, 010825 Bucharest, Romania, Department of Food Hygiene and Nutrition, ‘Carol Davila’ University of Medicine and Pharmacy, 050463 Bucharest, Romania
Published online on: November 4, 2021 https://doi.org/10.3892/etm.2021.10945
Article Number: 23

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Abstract

Pemphigoid gestationis is considered to be a rare pregnancy exclusive bullous disease, which modifies the course of the pregnancy, with difficulties in the management of the pruritus and skin lesions as well as a possible change in the neonatal outcome. Differential diagnosis of skin lesions and pruritus in pregnancy is challenging, and complementary investigations such as skin biopsy or laboratory tests are indispensable. The correct diagnosis and proper treatment could change the natural course of a pregnancy at risk and could improve maternal and fetal morbidity. We present the case of a patient with pemfigoid gestationis with the aim to highlight: i) the management of this pregnancy‑associated skin disorder which transfers this pregnancy into a category of high obstetrical risk pregnancy; ii) the particularities of the course of the pregnancy; and iii) the importance in the differential diagnosis of pregnancy dermatoses. The particularity of this case of pemphigoid gestationis was the acute fetal distress in the absence of intrauterine growth restriction that is frequently found in this pathology, and the management of a rare pregnancy skin condition that currently has no standard treatment.

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