Open Access

Clinicopathological correlation of transient acantholytic dermatosis: A case report

  • Authors:
    • Ilarie Brihan
    • Gyula László Fekete
    • Constanta Turda
    • Ovidiu Tica
    • Alina Cristiana Venter
    • Simona Ianosi
    • Carmen-Daniela Neagoe
    • Daciana Elena Branisteanu
  • View Affiliations

  • Published online on: December 28, 2021     https://doi.org/10.3892/etm.2021.11096
  • Article Number: 173
  • Copyright: © Brihan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Transient acantholytic dermatosis (TAD) is a benign, non‑familial, non‑immune mediated acantholytic disorder of unknown etiology. The presence of polymorphous, unorganized, pruritic lesions on the trunk, associated with focal acantholysis and dyskeratosis, resembles a wide variety of dermatoses. The etiology of TAD (also known as Grover's disease) is unknown, and the success of treatment relies on the correct identification of the disease; however, some cases are refractory to all forms of therapy. For accurate diagnosis, a comprehensive literature review is required. Here, the case of a 55‑year‑old male with TAD displaying a Darier‑like histopathological pattern was reported. The patient was successfully treated with retinoids and acitretin (Neotigason), as well as dapsone, an anti‑inflammatory agent, as maintenance therapy. The presence of more than two histological findings, limited to small foci and clinical information, can diagnose Darier disease. The exact pathogenesis has not been elucidated, thus further studies of the pathogenesis of TAD are required.
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February-2022
Volume 23 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Brihan I, Fekete GL, Turda C, Tica O, Venter AC, Ianosi S, Neagoe C and Branisteanu DE: Clinicopathological correlation of transient acantholytic dermatosis: A case report. Exp Ther Med 23: 173, 2022.
APA
Brihan, I., Fekete, G.L., Turda, C., Tica, O., Venter, A.C., Ianosi, S. ... Branisteanu, D.E. (2022). Clinicopathological correlation of transient acantholytic dermatosis: A case report. Experimental and Therapeutic Medicine, 23, 173. https://doi.org/10.3892/etm.2021.11096
MLA
Brihan, I., Fekete, G. L., Turda, C., Tica, O., Venter, A. C., Ianosi, S., Neagoe, C., Branisteanu, D. E."Clinicopathological correlation of transient acantholytic dermatosis: A case report". Experimental and Therapeutic Medicine 23.2 (2022): 173.
Chicago
Brihan, I., Fekete, G. L., Turda, C., Tica, O., Venter, A. C., Ianosi, S., Neagoe, C., Branisteanu, D. E."Clinicopathological correlation of transient acantholytic dermatosis: A case report". Experimental and Therapeutic Medicine 23, no. 2 (2022): 173. https://doi.org/10.3892/etm.2021.11096