Novel applications of platelet concentrates in tissue regeneration (Review)
- Authors:
- Zhen-Yu Ding
- Ying Tan
- Qian Peng
- Jun Zuo
- Ning Li
-
Affiliations: Hunan Key Laboratory of Oral Health Research, Hunan 3D Printing Engineering Research Center of Oral Care, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, Hunan 410008, P.R. China, Department of Blood Transfusion, Xiangya Hospital, Clinical Transfusion Research Center, Central South University, Changsha, Hunan 410008, P.R. China - Published online on: January 18, 2021 https://doi.org/10.3892/etm.2021.9657
- Article Number: 226
-
Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
 |
 |
|
Bishop CJ, Kim J and Green JJ: Biomolecule delivery to engineer the cellular microenvironment for regenerative medicine. Ann Biomed Eng. 42:1557–1572. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Abou Neel EA, Chrzanowski W, Salih VM, Kim HW and Knowles JC: Tissue engineering in dentistry. J Dent. 42:915–928. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Miron RJ and Zhang Y: Autologous liquid platelet rich fibrin: A novel drug delivery system. Acta Biomater. 75:35–51. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Kobayashi E, Flückiger L, Fujioka-Kobayashi M, Sawada K, Sculean A, Schaller B and Miron RJ: Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig. 20:2353–2360. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Miron RJ, Fujioka-Kobayashi M, Bishara M, Zhang Y, Hernandez M and Choukroun J: Platelet-rich fibrin and soft tissue wound healing: A systematic review. Tissue Eng Part B Rev. 23:83–99. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Alsousou J, Ali A, Willett K and Harrison P: The role of platelet-rich plasma in tissue regeneration. Platelets. 24:173–182. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Görmeli G, Görmeli CA, Ataoglu B, Çolak C, Aslantürk O and Ertem K: Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: A randomized, double-blind, placebo-controlled trial. Knee Surg Sports Traumatol Arthrosc. 25:958–965. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Huang Y, Liu X, Xu X and Liu J: Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis: A prospective randomized controlled study. Orthopade. 48:239–247. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Bhujbal R, A Malik N, Kumar N, Kv S, I Parkar M and Mb J: Comparative evaluation of platelet rich plasma in socket healing and bone regeneration after surgical removal of impacted mandibular third molars. J Dent Res Dent Clin Dent Prospect. 12:153–158. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Del Fabbro M, Bucchi C, Lolato A, Corbella S, Testori T and Taschieri S: Healing of postextraction sockets preserved with autologous platelet concentrates. A systematic review and meta-analysis. J Oral Maxillofac Surg. 75:1601–1615. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Alio JL, Rodriguez AE, De Arriba P, Gisbert S and Abdelghany AA: Treatment with platelet-rich plasma of surgically related dormant corneal ulcers. Eur J Ophthalmol. 28:515–520. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Tambella AM, Attili AR, Dini F, Palumbo Piccionello A, Vullo C, Serri E, Scrollavezza P and Dupré G: Autologous platelet gel to treat chronic decubital ulcers: A randomized, blind controlled clinical trial in dogs. Vet Surg. 43:726–733. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Tambella AM, Attili AR, Dupré G, Cantalamessa A, Martin S, Cuteri V, Marcazzan S and Del Fabbro M: Platelet-rich plasma to treat experimentally-induced skin wounds in animals: A systematic review and meta-analysis. PLoS One. 13(e0191093)2018.PubMed/NCBI View Article : Google Scholar | |
|
Burgos-Alonso N, Lobato I, Hernández I, San Sebastian K, Rodríguez B, March AG, Perez-Salvador A, Arce V, Garcia-Alvarez A, Gomez-Fernandez MC, et al: Autologous platelet-rich plasma in the treatment of venous leg ulcers in primary care: A randomised controlled, pilot study. J Wound Care. 27 (Suppl 6):S20–S24. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Martinez-Zapata MJ, Martí-Carvajal AJ, Solà I, Expósito JA, Bolíbar I, Rodríguez L, Garcia J and Zaror C: Autologous platelet-rich plasma for treating chronic wounds. Cochrane Database Syst Rev: May 25, 2016. doi: 10.1002/14651858.CD006899.pub3. | |
|
Moneib HA, Youssef SS, Aly DG, Rizk MA and Abdelhakeem YI: Autologous platelet-rich plasma versus conventional therapy for the treatment of chronic venous leg ulcers: A comparative study. J Cosmet Dermatol. 17:495–501. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Picard F, Hersant B, Bosc R and Meningaud JP: The growing evidence for the use of platelet-rich plasma on diabetic chronic wounds: A review and a proposal for a new standard care. Wound Repair Regen. 23:638–643. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Masoudi E, Ribas J, Kaushik G, Leijten J and Khademhosseini A: Platelet-rich blood derivatives for stem cell-based tissue engineering and regeneration. Curr Stem Cell Rep. 2:33–42. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Hatakeyama I, Marukawa E, Takahashi Y and Omura K: Effects of platelet-poor plasma, platelet-rich plasma, and platelet-rich fibrin on healing of extraction sockets with buccal dehiscence in dogs. Tissue Eng Part A. 20:874–882. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Anitua E, Nurden P, Prado R, Nurden AT and Padilla S: Autologous fibrin scaffolds: When platelet- and plasma-derived biomolecules meet fibrin. Biomaterials. 192:440–460. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J and Gogly B: Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 101:e45–e50. 2006.PubMed/NCBI View Article : Google Scholar | |
|
Shah R, M G T, Thomas R and Mehta DS: An Update on the protocols and biologic actions of platelet rich fibrin in dentistry. Eur J Prosthodont Restor Dent. 25:64–72. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Ghanaati S, Booms P, Orlowska A, Kubesch A, Lorenz J, Rutkowski J, Landes C, Sader R, Kirkpatrick C and Choukroun J: Advanced platelet-rich fibrin: A new concept for cell-based tissue engineering by means of inflammatory cells. J Oral Implantol. 40:679–689. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Wend S, Kubesch A, Orlowska A, Al-Maawi S, Zender N, Dias A, Miron RJ, Sader R, Booms P, Kirkpatrick CJ, et al: Reduction of the relative centrifugal force influences cell number and growth factor release within injectable PRF-based matrices. J Mater Sci Mater Med. 28(188)2017.PubMed/NCBI View Article : Google Scholar | |
|
Pitzurra L, Jansen IDC, de Vries TJ, Hoogenkamp MA and Loos BG: Effects of L-PRF and A-PRF+ on periodontal fibroblasts in in vitro wound healing experiments. J Periodontal Res. 55:287–295. 2020.PubMed/NCBI View Article : Google Scholar | |
|
Miron RJ, Fujioka-Kobayashi M, Hernandez M, Kandalam U, Zhang Y, Ghanaati S and Choukroun J: Injectable platelet rich fibrin (i-PRF): Opportunities in regenerative dentistry? Clin Oral Investig. 21:2619–2627. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Malli Sureshbabu N, Selvarasu K, v JK, Nandakumar M and Selvam D: Concentrated growth factors as an ingenious biomaterial in regeneration of bony defects after periapical surgery: A report of two cases. Case Rep Dent. 2019(7046203)2019.PubMed/NCBI View Article : Google Scholar | |
|
Dohan Ehrenfest DM, Rasmusson L and Albrektsson T: Classification of platelet concentrates: From pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 27:158–167. 2009.PubMed/NCBI View Article : Google Scholar | |
|
Boateng JS, Matthews KH, Stevens HN and Eccleston GM: Wound healing dressings and drug delivery systems: A review. J Pharm Sci. 97:2892–2923. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Broughton G II, Janis JE and Attinger CE: The basic science of wound healing. Plast Reconstr Surg. 117 (Suppl 7):12S–34S. 2006.PubMed/NCBI View Article : Google Scholar | |
|
Etulain J: Platelets in wound healing and regenerative medicine. Platelets. 29:556–568. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Walsh TG, Metharom P and Berndt MC: The functional role of platelets in the regulation of angiogenesis. Platelets. 26:199–211. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Pierce GF, Mustoe TA, Altrock BW, Deuel TF and Thomason A: Role of platelet-derived growth factor in wound healing. J Cell Biochem. 45:319–326. 1991.PubMed/NCBI View Article : Google Scholar | |
|
Briquez PS, Hubbell JA and Martino MM: Extracellular matrix-inspired growth factor delivery systems for skin wound healing. Adv Wound Care (New Rochelle). 4:479–489. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Martino MM, Brkic S, Bovo E, Burger M, Schaefer DJ, Wolff T, Gürke L, Briquez PS, Larsson HM, Gianni-Barrera R, et al: Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine. Front Bioeng Biotechnol. 3(45)2015.PubMed/NCBI View Article : Google Scholar | |
|
Janmey PA, Winer JP and Weisel JW: Fibrin gels and their clinical and bioengineering applications. J R Soc Interface. 6:1–10. 2009.PubMed/NCBI View Article : Google Scholar | |
|
Sánchez M, Anitua E, Delgado D, Prado R, Sánchez P, Fiz N, Guadilla J, Azofra J, Pompei O, Orive G, et al: Ultrasound-guided plasma rich in growth factors injections and scaffolds hasten motor nerve functional recovery in an ovine model of nerve crush injury. J Tissue Eng Regen Med. 11:1619–1629. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Haugh MG, Murphy CM and O'Brien FJ: Novel freeze-drying methods to produce a range of collagen-glycosaminoglycan scaffolds with tailored mean pore sizes. Tissue Eng Part C Methods. 16:887–894. 2010.PubMed/NCBI View Article : Google Scholar | |
|
Roy I and Gupta MN: Freeze-drying of proteins: Some emerging concerns. Biotechnol Appl Biochem. 39:165–177. 2004.PubMed/NCBI View Article : Google Scholar | |
|
Shi L, Li R, Wei S, Zhou M, Li L, Lin F, Li Y, Guo Z, Zhang W, Chen M, et al: Effects of a protective agent on freeze-dried platelet-rich plasma. Blood Coagul Fibrinolysis. 30:58–65. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Wang Z, Han L, Sun T, Wang W, Li X and Wu B: Preparation and effect of lyophilized platelet-rich fibrin on the osteogenic potential of bone marrow mesenchymal stem cells in vitro and in vivo. Heliyon. 5(e02739)2019.PubMed/NCBI View Article : Google Scholar | |
|
Li Q, Reed DA, Min L, Gopinathan G, Li S, Dangaria SJ, Li L, Geng Y, Galang MT, Gajendrareddy P, et al: Lyophilized platelet-rich fibrin (PRF) promotes craniofacial bone regeneration through Runx2. Int J Mol Sci. 15:8509–8525. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Zhang J, Qi X, Luo X, Li D, Wang H and Li T: Clinical and immunohistochemical performance of lyophilized platelet-rich fibrin (Ly-PRF) on tissue regeneration. Clin Implant Dent Relat Res. 19:466–477. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Liu Z, Jin H, Xie Q, Jiang Z, Guo S, Li Y and Zhang B: Controlled release strategies for the combination of fresh and lyophilized platelet-rich fibrin on bone tissue regeneration. BioMed Res Int. 2019(4923767)2019.PubMed/NCBI View Article : Google Scholar | |
|
Sam G, Vadakkekuttical RJ and Amol NV: In vitro evaluation of mechanical properties of platelet-rich fibrin membrane and scanning electron microscopic examination of its surface characteristics. J Indian Soc Periodontol. 19:32–36. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Behera SS, Das U, Kumar A, Bissoyi A and Singh AK: Chitosan/TiO2 composite membrane improves proliferation and survival of L929 fibroblast cells: Application in wound dressing and skin regeneration. Int J Biol Macromol. 98:329–340. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Mohammadi R, Mehrtash M, Mehrtash M, Hassani N and Hassanpour A: Effect of platelet rich plasma combined with chitosan biodegradable film on full-thickness wound healing in rat model. Bull Emerg Trauma. 4:29–37. 2016.PubMed/NCBI | |
|
Shimojo AA, Perez AG, Galdames SE, Brissac IC and Santana MH: Stabilization of porous chitosan improves the performance of its association with platelet-rich plasma as a composite scaffold. Mater Sci Eng C. 60:538–546. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Wang L, Wan M, Li Z, Zhong N, Liang D and Ge L: A comparative study of the effects of concentrated growth factors in two different forms on osteogenesis in vitro. Mol Med Rep. 20:1039–1048. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Ansarizadeh M, Mashayekhan S and Saadatmand M: Fabrication, modeling and optimization of lyophilized advanced platelet rich fibrin in combination with collagen-chitosan as a guided bone regeneration membrane. Int J Biol Macromol. 125:383–391. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Dal Pra I, Freddi G, Minic J, Chiarini A and Armato U: De novo engineering of reticular connective tissue in vivo by silk fibroin nonwoven materials. Biomaterials. 26:1987–1999. 2005.PubMed/NCBI View Article : Google Scholar | |
|
Horan RL, Antle K, Collette AL, Wang Y, Huang J, Moreau JE, Volloch V, Kaplan DL and Altman GH: In vitro degradation of silk fibroin. Biomaterials. 26:3385–3393. 2005.PubMed/NCBI View Article : Google Scholar | |
|
Franco AR, Fernandes EM, Rodrigues MT, Rodrigues FJ, Gomes ME, Leonor IB, Kaplan DL and Reis RL: Antimicrobial coating of spider silk to prevent bacterial attachment on silk surgical sutures. Acta Biomater. 99:236–246. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Lee EH, Kim JY, Kweon HY, Jo YY, Min SK, Park YW, Choi JY and Kim SG: A combination graft of low-molecular-weight silk fibroin with Choukroun platelet-rich fibrin for rabbit calvarial defect. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 109:e33–e38. 2010.PubMed/NCBI View Article : Google Scholar | |
|
Kuchur OA, Tsymbal SA, Shestovskaya MV, Serov NS, Dukhinova MS and Shtil AA: Metal-derived nanoparticles in tumor theranostics: Potential and limitations. J Inorg Biochem. 209(111117)2020.PubMed/NCBI View Article : Google Scholar | |
|
Zhang J, Xu Q, Huang C, Mo A, Li J and Zuo Y: Biological properties of an anti-bacterial membrane for guided bone regeneration: An experimental study in rats. Clin Oral Implants Res. 21:321–327. 2010.PubMed/NCBI View Article : Google Scholar | |
|
Khorshidi H, Haddadi P, Raoofi S, Badiee P and Dehghani Nazhvani A: Does adding silver nanoparticles to leukocyte- and platelet-rich fibrin improve its properties? BioMed Res Int. 2018(8515829)2018.PubMed/NCBI View Article : Google Scholar | |
|
Woo SM, Kim WJ, Lim HS, Choi NK, Kim SH, Kim SM and Jung JY: Combination of mineral trioxide aggregate and platelet-rich fibrin promotes the odontoblastic differentiation and mineralization of human dental pulp cells via BMP/Smad signaling pathway. J Endod. 42:82–88. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Abdullah WA: Evaluation of bone regenerative capacity in rats claverial bone defect using platelet rich fibrin with and without beta tri calcium phosphate bone graft material. Saudi Dent J. 28:109–117. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Karayürek F, Kadiroğlu ET, Nergiz Y, Coşkun Akçay N, Tunik S, Ersöz Kanay B and Uysal E: Combining platelet rich fibrin with different bone graft materials: An experimental study on the histopathological and immunohistochemical aspects of bone healing. J Craniomaxillofac Surg. 47:815–825. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Ohba S, Wang W, Itoh S, Takagi Y, Nagai A and Yamashita K: Acceleration of new bone formation by an electrically polarized hydroxyapatite microgranule/platelet-rich plasma composite. Acta Biomater. 8:2778–2787. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Sadeghinia A, Davaran S, Salehi R and Jamalpoor Z: Nano-hydroxy apatite/chitosan/gelatin scaffolds enriched by a combination of platelet-rich plasma and fibrin glue enhance proliferation and differentiation of seeded human dental pulp stem cells. Biomed Pharmacother. 109:1924–1931. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Suga H, Glotzbach JP, Sorkin M, Longaker MT and Gurtner GC: Paracrine mechanism of angiogenesis in adipose-derived stem cell transplantation. Ann Plast Surg. 72:234–241. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Klar AS, Güven S, Zimoch J, Zapiórkowska NA, Biedermann T, Böttcher-Haberzeth S, Meuli-Simmen C, Martin I, Scherberich A, Reichmann E, et al: Characterization of vasculogenic potential of human adipose-derived endothelial cells in a three-dimensional vascularized skin substitute. Pediatr Surg Int. 32:17–27. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Lee SH, Jin SY, Song JS, Seo KK and Cho KH: Paracrine effects of adipose-derived stem cells on keratinocytes and dermal fibroblasts. Ann Dermatol. 24:136–143. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Moon KM, Park YH, Lee JS, Chae YB, Kim MM, Kim DS, Kim BW, Nam SW and Lee JH: The effect of secretory factors of adipose-derived stem cells on human keratinocytes. Int J Mol Sci. 13:1239–1257. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Stessuk T, Puzzi MB, Chaim EA, Alves PC, de Paula EV, Forte A, Izumizawa JM, Oliveira CC, Frei F and Ribeiro-Paes JT: Platelet-rich plasma (PRP) and adipose-derived mesenchymal stem cells: Stimulatory effects on proliferation and migration of fibroblasts and keratinocytes in vitro. Arch Dermatol Res. 308:511–520. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Park CG, Joo MW, Jeong J, Kang YK and Lee DR: Evaluation of the effects of the combination of autologous mesenchymal stem cells and platelet-rich plasma on structural bone allograft healing. Cell Tissue Bank. 18:229–238. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Mills DC, Robb IA and Roberts GC: The release of nucleotides, 5-hydroxytryptamine and enzymes from human blood platelets during aggregation. J Physiol. 195:715–729. 1968.PubMed/NCBI View Article : Google Scholar | |
|
Chen Y, Niu Z, Xue Y, Yuan F, Fu Y and Bai N: Improvement in the repair of defects in maxillofacial soft tissue in irradiated minipigs by a mixture of adipose-derived stem cells and platelet-rich fibrin. Br J Oral Maxillofac Surg. 52:740–745. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Sun CK, Zhen YY, Leu S, Tsai TH, Chang LT, Sheu JJ, Chen YL, Chua S, Chai HT, Lu HI, et al: Direct implantation versus platelet-rich fibrin-embedded adipose-derived mesenchymal stem cells in treating rat acute myocardial infarction. Int J Cardiol. 173:410–423. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Wang X, Li G, Guo J, Yang L, Liu Y, Sun Q, Li R and Yu W: Hybrid composites of mesenchymal stem cell sheets, hydroxyapatite, and platelet-rich fibrin granules for bone regeneration in a rabbit calvarial critical-size defect model. Exp Ther Med. 13:1891–1899. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Wang ZS, Feng ZH, Wu GF, Bai SZ, Dong Y, Chen FM and Zhao YM: The use of platelet-rich fibrin combined with periodontal ligament and jaw bone mesenchymal stem cell sheets for periodontal tissue engineering. Sci Rep. 6(28126)2016.PubMed/NCBI View Article : Google Scholar | |
|
Wu CC, Sheu SY, Hsu LH, Yang KC, Tseng CC and Kuo TF: Intra-articular Injection of platelet-rich fibrin releasates in combination with bone marrow-derived mesenchymal stem cells in the treatment of articular cartilage defects: An in vivo study in rabbits. J Biomed Mater Res B Appl Biomater. 105:1536–1543. 2017.PubMed/NCBI View Article : Google Scholar | |
|
He X, Chen WX, Ban G, Wei W, Zhou J, Chen WJ and Li XY: A new method to develop human dental pulp cells and platelet-rich fibrin complex. J Endod. 42:1633–1640. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Graves LL, Bukata SV, Aghazadehsanai N, Chang TI, Garrett NR and Friedlander AH: Patients receiving parenteral bisphosphonates for malignant disease and having developed an atypical femoral fracture are at risk of concomitant osteonecrosis of the jaw: an evidence-based review. J Oral Maxillofac Surg. 74:2403–2408. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Lundberg AP, Roady PJ, Somrak AJ, Howes ME and Fan TM: Zoledronate-associated osteonecrosis of the jaw in a dog with appendicular osteosarcoma. J Vet Intern Med. 30:1235–1240. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Kharazmi M, Hallberg P, Warfvinge G and Michaëlsson K: Risk of atypical femoral fractures and osteonecrosis of the jaw associated with alendronate use compared with other oral bisphosphonates. Rheumatology (Oxford). 53:1911–1913. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Street J, Bao M, deGuzman L, Bunting S, Peale FV Jr, Ferrara N, Steinmetz H, Hoeffel J, Cleland JL, Daugherty A, et al: Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci USA. 99:9656–9661. 2002.PubMed/NCBI View Article : Google Scholar | |
|
Krüger TB, Herlofson BB, Landin MA and Reseland JE: Alendronate alters osteoblast activities. Acta Odontol Scand. 74:550–557. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Steller D, Herbst N, Pries R, Juhl D and Hakim SG: Positive impact of Platelet-rich plasma and Platelet-rich fibrin on viability, migration and proliferation of osteoblasts and fibroblasts treated with zoledronic acid. Sci Rep. 9(8310)2019.PubMed/NCBI View Article : Google Scholar | |
|
Ginés C, Cuesta S, Kireev R, García C, Rancan L, Paredes SD, Vara E and Tresguerres JAF: Protective effect of resveratrol against inflammation, oxidative stress and apoptosis in pancreas of aged SAMP8 mice. Exp Gerontol. 90:61–70. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Borsani E, Bonazza V, Buffoli B, Nocini PF, Albanese M, Zotti F, Inchingolo F, Rezzani R and Rodella LF: Beneficial effects of concentrated growth factors and resveratrol on human osteoblasts in vitro treated with bisphosphonates. BioMed Res Int. 2018(4597321)2018.PubMed/NCBI View Article : Google Scholar | |
|
Xu FT, Liang ZJ, Li HM, Peng QL, Huang MH, Li Q, Liang YD, Chi GY, Li H, Yu BC, et al: Ginsenoside Rg1 and platelet-rich fibrin enhance human breast adipose-derived stem cell function for soft tissue regeneration. Oncotarget. 7:35390–35403. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Raafat SN, Amin RM, Elmazar MM, Khattab MM and El-Khatib AS: The sole and combined effect of simvastatin and platelet rich fibrin as a filling material in induced bone defect in tibia of albino rats. Bone. 117:60–69. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Isobe K, Watanebe T, Kawabata H, et al: Mechanical and degradation properties of advanced platelet-rich fibrin (A-PRF), concentrated growth factors (CGF), and platelet-poor plasma-derived fibrin (PPTF). Int J Implant Dent. 3(17)2017.PubMed/NCBI View Article : Google Scholar | |
|
Masuki H, Okudera T, Watanebe T, et al: Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF). Int J Implant Dent. 2:2016.PubMed/NCBI View Article : Google Scholar |
