Inherited thrombophilia is significantly associated with severe preeclampsia

  • Authors:
    • Roxana Elena Bohiltea
    • Monica Mihaela Cirstoiu
    • Natalia Turcan
    • Anca Pantea Stoian
    • Corina-Aurelia Zugravu
    • Octavian Munteanu
    • Luciana Valentina Arsene
    • Bodean Oana
    • Adrian Neacsu
    • Florentina Furtunescu
  • View Affiliations

  • Published online on: January 25, 2021     https://doi.org/10.3892/etm.2021.9691
  • Article Number: 261
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Abstract

Methods to prevent the development of pathologies due to placental dysfunctions, such as gestational hypertension and preeclampsia, are the main approaches for obtaining the best maternal and fetal antepartum and postpartum prognosis. During 5 years of study (January, 2015 to December, 2019), the cases of pregnancy and puerperium complicated with pathology due to placental dysfunction were analyzed. The main objective was to determine the magnitude of the impact of thrombophilia on the development of an entity of gestational hypertension disorder. We compared the impact of thrombophilia and its associated complications in patients with gestational hypertension with moderate and severe preeclampsia. Thus, we found obesity, thrombophilia, and underlying cardiac pathology to be significant risk factors for severe preeclampsia. Regarding the comparative analysis of the risk factors and complications associated with patients with mild preeclampsia compared with those with severe preeclampsia, the presence in severe preeclampsia of thrombophilia, endocrine, liver, and cardiac pathology was higher and, a higher rate of complications was observed; complications included fetal death, intrauterine growth restriction (IUGR), prematurity, fetal arrhythmia with acute fetal distress, HELLP syndrome, and placental abruption. Thrombophilia has a significant effect on the development of severe preeclampsia, and oligohydramnios as specific complication of mild preeclampsia. Factors indicating an increased risk of progression from mild preeclampsia to severe preeclampsia are in addition to inherited thrombophilia the underlying pathologies, namely cardiac, hepatic, and endocrine factors.
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March-2021
Volume 21 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Bohiltea RE, Cirstoiu MM, Turcan N, Stoian AP, Zugravu C, Munteanu O, Arsene LV, Oana B, Neacsu A, Furtunescu F, Furtunescu F, et al: Inherited thrombophilia is significantly associated with severe preeclampsia. Exp Ther Med 21: 261, 2021.
APA
Bohiltea, R.E., Cirstoiu, M.M., Turcan, N., Stoian, A.P., Zugravu, C., Munteanu, O. ... Furtunescu, F. (2021). Inherited thrombophilia is significantly associated with severe preeclampsia. Experimental and Therapeutic Medicine, 21, 261. https://doi.org/10.3892/etm.2021.9691
MLA
Bohiltea, R. E., Cirstoiu, M. M., Turcan, N., Stoian, A. P., Zugravu, C., Munteanu, O., Arsene, L. V., Oana, B., Neacsu, A., Furtunescu, F."Inherited thrombophilia is significantly associated with severe preeclampsia". Experimental and Therapeutic Medicine 21.3 (2021): 261.
Chicago
Bohiltea, R. E., Cirstoiu, M. M., Turcan, N., Stoian, A. P., Zugravu, C., Munteanu, O., Arsene, L. V., Oana, B., Neacsu, A., Furtunescu, F."Inherited thrombophilia is significantly associated with severe preeclampsia". Experimental and Therapeutic Medicine 21, no. 3 (2021): 261. https://doi.org/10.3892/etm.2021.9691