Early diagnosis of serum sICAM‑1 and sRAGE in severe acute pancreatitis, and efficacy and prognosis prediction of glutamine combined with ulinastatin

Shan,Lini; Bai,Shixian; Zhao,Min

doi:10.3892/etm.2021.9755

Early diagnosis of serum sICAM‑1 and sRAGE in severe acute pancreatitis, and efficacy and prognosis prediction of glutamine combined with ulinastatin

Authors:
- Lini Shan
- Shixian Bai
- Min Zhao
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Affiliations: Department of Pharmacy, Yidu Central Hospital of Weifang, Qingzhou, Shandong 262500, P.R. China, Intensive Care Unit, Yidu Central Hospital of Weifang, Qingzhou, Shandong 262500, P.R. China
Published online on: February 5, 2021 https://doi.org/10.3892/etm.2021.9755
Article Number: 324
Copyright: © Shan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute pancreatitis (AP) is a common gastrointestinal disease that can become severe, so that intensive care may be required. This study was to examine serum soluble intercellular adhesion molecule‑1 (sICAM‑1), and soluble receptor for advanced glycation end products (sRAGE) for efficacy and prognosis prediction of glutamine (Glu) combined with ulinastatin (UTI) on severe acute pancreatitis (SAP). Fifty‑four mild acute pancreatitis (MAP) patients admitted to Yidu Central Hospital of Weifang were selected as the MAP group (MAPG), 80 with SAP were divided as the SAP group (SAPG), and 60 healthy individuals who came to Yidu Central Hospital of Weifang for physical examination during the same period were included to the normal group (NG). Serum sICAM‑1 and sRAGE were measured and their predictive value of efficacy and prognosis were analyzed. In view of the treatment effectiveness and prognosis, the patients were divided into effective group (EG) and ineffective group (IG), good prognosis group (GPG) and poor prognosis group (PPG). The levels of D‑lactate, diamine oxidase (DAO), endotoxin and T‑lymphocyte subsets (CD3⁺, CD4⁺, CD8⁺ and CD4⁺/CD8⁺) were measured and the changes before and after treatment were analyzed. The AUC values of NG and MAPG, NG and SAPG, MAPG and SAPG were 0.857, 0.939 and 0.856, respectively, those of predicting efficacy were 0.920 and 0.874, respectively, and those of poor prognosis in the SAPG were 0.914 and 0.879, respectively. In the SAPG, D‑lactate, DAO, endotoxin and CD8⁺ decreased markedly after treatment, but CD3⁺, CD4⁺, and CD4⁺/CD8⁺ were opposite. SICAM‑1 and sRAGE were also independent risk factors for poor prognosis in the SAPG. Serum sICAM‑1 and sRAGE have high predictive value for early diagnosis, efficacy and prognosis of Glu combined with UTI.

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