Open Access

Green tea extract synergistically enhances the effectiveness of an antiresorptive drug on management of osteoporosis induced by ovariectomy in a rat model

  • Authors:
    • Wing Sum Siu
    • Chun Hay Ko
    • Hoi Ting Shiu
    • Kai Kai Li
    • Wai Ting Shum
    • Ping Chung Leung
    • Jin Fang Zhang
  • View Affiliations

  • Published online on: February 5, 2021     https://doi.org/10.3892/etm.2021.9759
  • Article Number: 328
  • Copyright: © Siu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Antiresorptive drugs are effective for reducing bone loss in postmenopausal women, but their long‑term application may be associated with adverse effects. The present study aimed to investigate the potential in vivo synergistic effects of green tea extract (GTE) and alendronate or raloxifene on the management of osteoporosis. Ovariectomized rats were fed orally with GTE, alendronate and raloxifene at different concentrations and various combinations for 4 weeks. Bone mineral density (BMD) at the lumbar spine, femur and tibia was monitored weekly using peripheral quantitative computed tomography. Bone microarchitecture in the left distal femur was analyzed using micro‑CT, while serum biochemical levels were measured using ELISA kits at the end of the study. GTE alone effectively mitigated BMD loss and improved bone microarchitecture in rats. The co‑administration of GTE and alendronate increased total BMD in the lumbar spine, femur and tibia. Particularly, GTE synergistically enhanced the effect of alendronate at a low dose on bone microarchitecture and decreased serum tartrate‑resistant acid phosphatase. These findings imply that the dosage of certain antiresorptive agents could be reduced when they are administrated simultaneously with GTE, so that their adverse effects are minimized. The findings may be used to support the development of a new synergistic intervention between food therapy and pharmacotherapy on the management of osteoporosis in a long‑term basis.
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April-2021
Volume 21 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Siu W, Ko C, Shiu H, Li K, Shum W, Leung P and Zhang J: Green tea extract synergistically enhances the effectiveness of an antiresorptive drug on management of osteoporosis induced by ovariectomy in a rat model. Exp Ther Med 21: 328, 2021.
APA
Siu, W., Ko, C., Shiu, H., Li, K., Shum, W., Leung, P., & Zhang, J. (2021). Green tea extract synergistically enhances the effectiveness of an antiresorptive drug on management of osteoporosis induced by ovariectomy in a rat model. Experimental and Therapeutic Medicine, 21, 328. https://doi.org/10.3892/etm.2021.9759
MLA
Siu, W., Ko, C., Shiu, H., Li, K., Shum, W., Leung, P., Zhang, J."Green tea extract synergistically enhances the effectiveness of an antiresorptive drug on management of osteoporosis induced by ovariectomy in a rat model". Experimental and Therapeutic Medicine 21.4 (2021): 328.
Chicago
Siu, W., Ko, C., Shiu, H., Li, K., Shum, W., Leung, P., Zhang, J."Green tea extract synergistically enhances the effectiveness of an antiresorptive drug on management of osteoporosis induced by ovariectomy in a rat model". Experimental and Therapeutic Medicine 21, no. 4 (2021): 328. https://doi.org/10.3892/etm.2021.9759