Open Access

Chimeric antigen receptor‑natural killer cells: novel insight into immunotherapy for solid tumors (Review)

  • Authors:
    • Xiaobo Peng
    • Ling Chen
    • Longpei Chen
    • Bin Wang
    • Yiran Wang
    • Xianbao Zhan
  • View Affiliations

  • Published online on: February 10, 2021     https://doi.org/10.3892/etm.2021.9771
  • Article Number: 340
  • Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The chimeric antigen receptor (CAR) is an artificially modified fusion protein consisting of an extracellular antigen‑binding domain, transmembrane domain and intracellular signalling domain. CAR‑T therapy has demonstrated remarkable clinical efficacy in hematological malignancies. However, cytokine release syndrome and other side effects have hindered its application in solid tumors. CAR‑natural killer (NK) cells have attracted broad attention due to their safety in clinical applications, their mechanism in recognising cancer cells and the abundance of its clinical specimens. Preclinical and clinical trials of human primary NK cells and NK‑92 cell lines demonstrated that CAR‑NK cells are able to fight haematological malignancies and solid tumors. However, the implication of CAR‑NK cell therapy also has certain challenges, including the expansion and activation of primary NK cells in vitro, selection of CAR targets, survival time of CAR‑NK cells in vivo, storage and transportation of NK cells, and efficiency of NK cell transduction. This review focuses on the latest progress of CAR‑NK cells in the treatment of solid tumors.
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April-2021
Volume 21 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Peng X, Chen L, Chen L, Wang B, Wang Y and Zhan X: Chimeric antigen receptor‑natural killer cells: novel insight into immunotherapy for solid tumors (Review). Exp Ther Med 21: 340, 2021
APA
Peng, X., Chen, L., Chen, L., Wang, B., Wang, Y., & Zhan, X. (2021). Chimeric antigen receptor‑natural killer cells: novel insight into immunotherapy for solid tumors (Review). Experimental and Therapeutic Medicine, 21, 340. https://doi.org/10.3892/etm.2021.9771
MLA
Peng, X., Chen, L., Chen, L., Wang, B., Wang, Y., Zhan, X."Chimeric antigen receptor‑natural killer cells: novel insight into immunotherapy for solid tumors (Review)". Experimental and Therapeutic Medicine 21.4 (2021): 340.
Chicago
Peng, X., Chen, L., Chen, L., Wang, B., Wang, Y., Zhan, X."Chimeric antigen receptor‑natural killer cells: novel insight into immunotherapy for solid tumors (Review)". Experimental and Therapeutic Medicine 21, no. 4 (2021): 340. https://doi.org/10.3892/etm.2021.9771