Prognostic value of miR‑339‑5p in patients with prostate cancer and its effects on tumor progression

  • Authors:
    • Huafeng Pan
    • Xin Rui
    • Wei Wei
    • Siliang Shao
    • Yudi Zhu
  • View Affiliations

  • Published online on: February 24, 2021     https://doi.org/10.3892/etm.2021.9821
  • Article Number: 390
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Abstract

Prostate cancer places a serious health burden on males. The present study aimed to explore the potential prognostic significance and biological function of microRNA (miR)‑339‑5p in patients with prostate cancer. The expression of miR‑339‑5p was detected in prostate cancer tissues and cell lines by using reverse transcription‑quantitative PCR. Kaplan‑Meier survival curves and Cox regression analyses were used to investigate the prognostic significance of miR‑339‑5p in prostate cancer. The Cell Counting Kit‑8 assay was used to determine the effect of miR‑339‑5p on prostate cancer cell proliferation. Transwell assays were used to assess the effect of miR‑339‑5p on cell migration and invasion. The results indicated that the expression of miR‑339‑5p was downregulated in prostate cancer tissues and cell lines. Downregulation of miR‑339‑5p was significantly associated with the Gleason score, lymph node metastasis and TNM stage. Patients with high miR‑339‑5p expression levels had a longer survival time than those with low expression levels. Multivariate Cox regression analysis indicated that miR‑339‑5p may be an independent prognostic factor for the overall survival of patients with prostate cancer. Overexpression of miR‑339‑5p inhibited the proliferation, migration and invasion of prostate cancer cells. Taken together, these results indicated that miR‑339‑5p functions as a suppressor gene in prostate cancer and acts by inhibiting cell proliferation, migration and invasion of prostate cancer cells. miR‑339‑5p may serve as an independent prognostic biomarker and therapeutic target for the treatment of prostate cancer.
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April-2021
Volume 21 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Pan H, Rui X, Wei W, Shao S and Zhu Y: Prognostic value of miR‑339‑5p in patients with prostate cancer and its effects on tumor progression. Exp Ther Med 21: 390, 2021
APA
Pan, H., Rui, X., Wei, W., Shao, S., & Zhu, Y. (2021). Prognostic value of miR‑339‑5p in patients with prostate cancer and its effects on tumor progression. Experimental and Therapeutic Medicine, 21, 390. https://doi.org/10.3892/etm.2021.9821
MLA
Pan, H., Rui, X., Wei, W., Shao, S., Zhu, Y."Prognostic value of miR‑339‑5p in patients with prostate cancer and its effects on tumor progression". Experimental and Therapeutic Medicine 21.4 (2021): 390.
Chicago
Pan, H., Rui, X., Wei, W., Shao, S., Zhu, Y."Prognostic value of miR‑339‑5p in patients with prostate cancer and its effects on tumor progression". Experimental and Therapeutic Medicine 21, no. 4 (2021): 390. https://doi.org/10.3892/etm.2021.9821