Open Access

Meta‑analysis of laboratory results in patients with severe coronavirus disease 2019

  • Authors:
    • Yun Huang
    • Yuyu Zhang
    • Lili Ma
  • View Affiliations

  • Published online on: March 1, 2021     https://doi.org/10.3892/etm.2021.9877
  • Article Number: 449
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to analyze the differences in laboratory results between patients with severe and moderate coronavirus disease 2019 (COVID‑19) for clinical intervention. The laboratory results of patients with COVID‑19 between December 2019 and May 2020 were assembled from the Medline, Embase and Cochrane Library databases. A meta‑analysis was conducted, calculating the individual and pooled odds ratios (ORs) with relative 95% confidence intervals (95% CIs) using Review Manager 5.3. The available data of 1,534 patients from 6 studies were included in this analysis. The results demonstrated that the incidence of leukocytosis, lymphocytopenia, increased procalcitonin (PCT), C‑reactive protein (CRP), aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) levels was associated with a nearly 3‑fold (OR=3.44; 95% CI: 2.15‑5.49), 4‑fold (OR=4.39; 95% CI: 1.82‑10.60), 5‑fold (OR=5.28; 95% CI: 3.42‑8.15), 4‑fold (OR=3.99; 95% CI: 2.61‑6.12), 3‑fold (OR=3.02; 95% CI: 2.13‑4.26) and 8‑fold (OR=8.33; 95% CI: 1.75‑39.69) higher risk of severe COVID‑19 infection, respectively. These findings indicated that serial white blood cell count, lymphocyte count, CRP, PCT, LDH and AST measurements may be useful for predicting progression towards a more severe form of COVID‑19.
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May-2021
Volume 21 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Huang Y, Zhang Y and Ma L: Meta‑analysis of laboratory results in patients with severe coronavirus disease 2019. Exp Ther Med 21: 449, 2021.
APA
Huang, Y., Zhang, Y., & Ma, L. (2021). Meta‑analysis of laboratory results in patients with severe coronavirus disease 2019. Experimental and Therapeutic Medicine, 21, 449. https://doi.org/10.3892/etm.2021.9877
MLA
Huang, Y., Zhang, Y., Ma, L."Meta‑analysis of laboratory results in patients with severe coronavirus disease 2019". Experimental and Therapeutic Medicine 21.5 (2021): 449.
Chicago
Huang, Y., Zhang, Y., Ma, L."Meta‑analysis of laboratory results in patients with severe coronavirus disease 2019". Experimental and Therapeutic Medicine 21, no. 5 (2021): 449. https://doi.org/10.3892/etm.2021.9877