Congenital dyserythropoietic anemia and drug‑induced liver injury present as bland cholestasis: A case report

  • Authors:
    • Yue Han
    • Yan Zhuang
    • Weiliang Tang
    • Lu Chen
    • Yejing Chen
    • Qiming Gong
    • Xinxin Zhang
  • View Affiliations

  • Published online on: March 2, 2021     https://doi.org/10.3892/etm.2021.9887
  • Article Number: 456
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Abstract

Anemias and drug‑induced liver injury(DILI) are separate disorders, which are difficult to diagnose. The clinical effects of DILI vary among individuals. However, the outcome determinants remain to be fully established. To the best of our knowledge, the role of anemia in DILI has yet to be reported. The present study reported on the case of one Chinese patient (male; age, 21 years) who experienced obvious drug‑induced cholestasis. Of note, the hepatocyte injury was minimal compared with that in previously reported cases treated with the same drug. In addition, the patient suffered from mild hemolytic anemia with no obvious cause. A genetic pedigree analysis revealed compound heterozygous mutations in the congenital anemia‑associated gene codanin 1, including the novel rare p.R1067H mutation. Treatment with ursodeoxycholic acid alone sufficed and the outcome was good. Therefore, whilst chronic hemolysis predisposed the liver to cholestasis, it could have shielded the liver from further injuries, since bilirubin, a by‑product of hemolysis, is a known antioxidant. The results of the present study indicated that genetic screening may be used for the diagnosis of liver injury concurring with undiagnosed anemia.
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May-2021
Volume 21 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Han Y, Zhuang Y, Tang W, Chen L, Chen Y, Gong Q and Zhang X: Congenital dyserythropoietic anemia and drug‑induced liver injury present as bland cholestasis: A case report. Exp Ther Med 21: 456, 2021.
APA
Han, Y., Zhuang, Y., Tang, W., Chen, L., Chen, Y., Gong, Q., & Zhang, X. (2021). Congenital dyserythropoietic anemia and drug‑induced liver injury present as bland cholestasis: A case report. Experimental and Therapeutic Medicine, 21, 456. https://doi.org/10.3892/etm.2021.9887
MLA
Han, Y., Zhuang, Y., Tang, W., Chen, L., Chen, Y., Gong, Q., Zhang, X."Congenital dyserythropoietic anemia and drug‑induced liver injury present as bland cholestasis: A case report". Experimental and Therapeutic Medicine 21.5 (2021): 456.
Chicago
Han, Y., Zhuang, Y., Tang, W., Chen, L., Chen, Y., Gong, Q., Zhang, X."Congenital dyserythropoietic anemia and drug‑induced liver injury present as bland cholestasis: A case report". Experimental and Therapeutic Medicine 21, no. 5 (2021): 456. https://doi.org/10.3892/etm.2021.9887