D‑ribose: Potential clinical applications in congestive heart failure and diabetes, and its complications (Review)
- Authors:
- Shuai Li
- Juanjing Wang
- Yutian Xiao
- Li Zhang
- Jinren Fang
- Nanyang Yang
- Zhixia Zhang
- Moussa Ide Nasser
- Hui Qin
-
Affiliations: Institute of Cytology and Genetics, Hengyang Medical College, University of South China, Hengyang, Hunan 421000, P.R. China, School of Pharmaceutical Science, University of South China, Hengyang, Hunan 421000, P.R. China, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, P.R. China - Published online on: March 17, 2021 https://doi.org/10.3892/etm.2021.9927
- Article Number: 496
-
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
 |
 |
|
Bailey JM: The consequences for amino acid homochirality if L-ribose RNA and not D-ribose RNA had evolved first. Biochem Soc Trans. 25(S651)1997.PubMed/NCBI View Article : Google Scholar | |
|
Ban J, Shabbir S, Lim M, Lee B and Rhee H: Synthesis of l-ribose from d-ribose by a stereoconversion through sequential lactonization as the key transformation. Synthesis. 49:4299–4302. 2017. | |
|
Chen B, Jamieson ER and Tullius TD: A general synthesis of specifically deuterated nucleotides for studies of DNA and RNA. Bioorg Med Chem Lett. 4:3093–3096. 2002.PubMed/NCBI View Article : Google Scholar | |
|
Illangasekare M, Turk R, Peterson GC, Lladser M and Yarus M: Chiral histidine selection by D-ribose RNA. RNA. 16:2370–2383. 2010.PubMed/NCBI View Article : Google Scholar | |
|
Huisman TH, Martis EA and Dozy A: Chromatography of hemoglobin types on carboxymethylcellulose. J Lab Clin Med. 52:312–327. 1958.PubMed/NCBI | |
|
Steinberg T, Poucher RL, Sarin RK, Rees RB and Gwinup G: Oral administration of D-ribose in diabetes mellitus. Diabetes. 19:11–16. 1970.PubMed/NCBI View Article : Google Scholar | |
|
Pierce JD, Mahoney DE, Hiebert JB, Thimmesch AR, Diaz FJ, Smith C, Shen Q, Mudaranthakam DP and Clancy RL: Study protocol, randomized controlled trial: Reducing symptom burden in patients with heart failure with preserved ejection fraction using ubiquinol and/or D-ribose. BMC Cardiovasc Disord. 18(57)2018.PubMed/NCBI View Article : Google Scholar | |
|
MacCarter D, Vijay N, Washam M, Shecterle L, Sierminski H and St Cyr JA: D-ribose aids advanced ischemic heart failure patients. Int J Cardiol. 137:79–80. 2009.PubMed/NCBI View Article : Google Scholar | |
|
Bayram M, St Cyr JA and Abraham WT: D-ribose aids heart failure patients with preserved ejection fraction and diastolic dysfunction: A pilot study. Ther Adv Cardiovasc Dis. 9:56–65. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Bao-Hui Y, Qi D, Gui-Qin L and Zheng-Ping W: The physiological function of D-ribose and its application. Inst Biopharm Res. 210–212. 2016. | |
|
zur Nedden S, Doney AS and Frenguelli BG: Modulation of intracellular ATP determines adenosine release and functional outcome in response to metabolic stress in rat hippocampal slices and cerebellar granule cells. J Neurochem. 128:111–124. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Pauly DF and Pepine CJ: D-Ribose as a supplement for cardiac energy metabolism. J Cardiovasc Pharmacol Ther. 5:249–258. 2000.PubMed/NCBI View Article : Google Scholar | |
|
Addis P, Shecterle LM and St Cyr JA: Cellular protection during oxidative stress: A potential role for D-ribose and antioxidants. J Diet Suppl. 9:178–182. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Busca A and Parra-Herran C: The role of pathologic evaluation of endometrial ablation resections in predicting ablation failure and adenomyosis in hysterectomy. Pathol Res Pract. 212:778–782. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Nakamura K, Nakayama K, Ishikawa M, Katagiri H, Katagiri A, Ishibashi T, Sato E, Asakawa Y and Kyo S: Efficacy of multiple microwave endometrial ablation technique for menorrhagia resulting from adenomyosis. J Obstet Gynaecol Res. 41:1769–1772. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Conway VD, Race BA and Chigrinskiy EA: Role of ribose deficit in rat testicular metabolism under conditions of overtraining. Bull Exp Biol Med. 150:649–651. 2011.PubMed/NCBI View Article : Google Scholar | |
|
Kreider RB, Melton C, Greenwood M, Rasmussen C, Lundberg J, Earnest C and Almada A: Effects of oral D-ribose supplementation on anaerobic capacity and selected metabolic markers in healthy males. Int J Sport Nutr Exerc Metab. 13:76–86. 2003.PubMed/NCBI View Article : Google Scholar | |
|
Seifert JG, Brumet A and St Cyr JA: The influence of D-ribose ingestion and fitness level on performance and recovery. J Int Soc Sports Nutr. 14(47)2017.PubMed/NCBI View Article : Google Scholar | |
|
Wei Y, Han CS, Zhou J, Liu Y, Chen L and He RQ: D-ribose in glycation and protein aggregation. Biochim Biophys Acta. 1820:488–494. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Omran H, Illien S, MacCarter D, St Cyr J and Lüderitz B: D-Ribose improves diastolic function and quality of life in congestive heart failure patients: A prospective feasibility study. Eur J Heart Fail. 5:615–619. 2003.PubMed/NCBI View Article : Google Scholar | |
|
Shecterle LM, Terry KR and St Cyr JA: Potential clinical benefits of D-ribose in ischemic cardiovascular disease. Cureus. 10(e2291)2018.PubMed/NCBI View Article : Google Scholar | |
|
Wallen WJ, Belanger MP and Wittnich C: Preischemic administration of ribose to delay the onset of irreversible ischemic injury and improve function: Studies in normal and hypertrophied hearts. Can J Physiol Pharmacol. 81:40–47. 2003.PubMed/NCBI View Article : Google Scholar | |
|
Chen X, Su T, Chen Y, He Y, Liu Y, Xu Y, Wei Y, Li J and He R: d-Ribose as a contributor to glycated haemoglobin. EBioMedicine. 25:143–153. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Yuan BH, Liu GQ, Liu M, Li DC, Han J and Wang ZP: Study on the anti-fatigue effect of compound D-ribose on mice. Sci Technol Food Ind. 349–353. 2016. | |
|
Tsakiris N, Papavasileiou M, Bozzato E, Lopes A, Vigneron AM and Préat V: Combinational drug-loaded lipid nanocapsules for the treatment of cancer. Int J Pharm. 569(118588)2019.PubMed/NCBI View Article : Google Scholar | |
|
Derosa G, Pasqualotto S, Catena G, D'Angelo A, Maggi A and Maffioli P: A randomized, double-blind, placebo-controlled study to evaluate the effectiveness of a food supplement containing creatine and D-ribose combined with a physical exercise program in increasing stress tolerance in patients with ischemic heart disease. Nutrients. 11(3075)2019.PubMed/NCBI View Article : Google Scholar | |
|
Jhawar SR, Goyal S, Thandoni A, Wu H, Hassan S, Schiff DS, Allen J, Stogniew M, Tarapore R, Stein M, et al: Combination radiation therapy and imipridone ONC201 for the treatment of solid tumors. Int J Radiat Oncol Biol Phys. 99 (Suppl 2):E598–E599. 2017. | |
|
Kajiwara H: Motif 2 in adenosine kinase homologous ginseng polypeptide showed affinity to D-ribose by capillary zone electrophoresis and surface plasmon resonance. J Chromatogr A. 817:173–179. 1998.PubMed/NCBI View Article : Google Scholar | |
|
Ataka S, Tanaka M, Nozaki S, Mizuma H, Mizuno K, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, et al: Effects of oral administration of caffeine and D-ribose on mental fatigue. Nutrition. 24:233–238. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Yuanbao Hui LQ, Min L, Cheng L, Jun H and Ping W: Study on anti- fatigue effect of compound D-ribose on mice. Sci Technol Food Ind. 22:349–353. 2016. | |
|
Kitamoto T, Sakurai K, Lee EY, Yokote K, Accili D and Miki T: Distinct roles of systemic and local actions of insulin on pancreatic β-cells. Metabolism. 82:100–110. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Czech MP: Insulin action and resistance in obesity and type 2 diabetes. Nat Med. 23:804–814. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Zhang Y, Sun S, Jia H, Qi Y, Zhang J, Lin L, Chen Y, Wang W and Ning G: The optimized calculation method for insulin dosage in an insulin tolerance test (ITT): A randomized parallel control study. Front Endocrinol (Lausanne). 11(202)2020.PubMed/NCBI View Article : Google Scholar | |
|
Petersen MC and Shulman GI: Mechanisms of insulin action and insulin resistance. Physiol Rev. 98:2133–2223. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Adeva-Andany M, Souto-Adeva G, Ameneiros-Rodríguez E, Fernández-Fernández C, Donapetry-García C and Domínguez-Montero A: Insulin resistance and glycine metabolism in humans. Amino Acids. 50:11–27. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Hong J, Wang X, Zhang N, Fu H and Li W: D-ribose induces nephropathy through RAGE-dependent NF-κB inflammation. Arch Pharm Res. 41:838–847. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Rassaf T and Totzeck M: Modern concepts in cardio-oncology. J Thorac Dis. 10 (Suppl 35):S4386–S4390. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Williams JW, Huang LH and Randolph GJ: Cytokine circuits in cardiovascular disease. Immunity. 50:941–954. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Shaito A, Thuan DTB, Phu HT, Nguyen THD, Hasan H, Halabi S, Abdelhady S, Nasrallah GK, Eid AH and Pintus G: Herbal medicine for cardiovascular diseases: Efficacy, mechanisms, and safety. Front Pharmacol. 11(422)2020.PubMed/NCBI View Article : Google Scholar | |
|
MA LF, Yang SQ and Yang QJ: Protective effect of exogenous D-ribose on myocardial ischemia/reperfusion injury of rat hearts. J Chongqing Med Univ. 6:689–692. 2011.(In Chinese). | |
|
Sen S and Chakraborty R: Treatment and diagnosis of diabetes mellitus and its complication: Advanced approaches. Mini Rev Med Chem. 15:1132–1133. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Nagai R, Murray DB, Metz TO and Baynes JW: Chelation: A fundamental mechanism of action of AGE inhibitors, AGE breakers, and other inhibitors of diabetes complications. Diabetes. 61:549–559. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Salci MA, Meirelles BHS and Silva DMVGD: Prevention of chronic complications of diabetes mellitus according to complexity. Rev Bras Enferm. 70:996–1003. 2017.PubMed/NCBI View Article : Google Scholar : (In English, Portuguese). | |
|
You Y, Liu F, Gao S, Lin Y and Ge B: D-ribose Induced Rapid Non-enzymatic Glycation of Human Myoglobin. J Nanhua Univ. 44499–503. (535)2016. | |
|
Chehregosha H, Khamseh ME, Malek M, Hosseinpanah F and Ismail-Beigi F: A view beyond HbA1c: Role of continuous glucose monitoring. Diabetes Ther. 10:853–863. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Yap CW, Ang YG, Quek TPL, Heng BH and Chew DEK: Re-examining the sensitivity of HbA1c to screen for diabetes mellitus. J Diabetes. 10:380–385. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Siddiqui Z, Faisal M, Alatar AR and Ahmad S: Prevalence of auto-antibodies against D-ribose-glycated-hemoglobin in diabetes mellitus. Glycobiology. 29:409–418. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Chen Y, Yu L, Wang Y, Wei Y, Xu Y, He T and He R: d-Ribose contributes to the glycation of serum protein. Biochim Biophys Acta Mol Basis Dis. 1865:2285–2292. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Yamamoto Y and Yamamoto H: RAGE-mediated inflammation, type 2 diabetes, and diabetic vascular complication. Front Endocrinol (Lausanne). 4(105)2013.PubMed/NCBI View Article : Google Scholar | |
|
brutorum WTDa: An account of some books. Philos Trans R Soc Lond. 7:4071–4078. 1672. | |
|
Ekbom KA: Asthenia crurum paraesthetica (Irritable legs). Acta Med Scand. 118:197–209. 1944. | |
|
Shecterle L, Kasubick R and Cyr JS: D-ribose benefits restless legs syndrome. J Altern Complement Med. 14:1165–1166. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Teitelbaum J, Jandrain J and McGrew R: Treatment of chronic fatigue syndrome and fibromyalgia with D-ribose-an open-label, multicenter study. Open Pain J. 5:32–37. 2012. | |
|
Gebhart B and Jorgenson JA: Benefit of ribose in a patient with fibromyalgia. Pharmacotherapy. 24:1646–1648. 2004.PubMed/NCBI View Article : Google Scholar | |
|
Arnaud JP: Cosmetic use of D-ribose and method thereof. United States Patent Application Publication, 2007. | |
|
Shecterle LM and St Cyr JA: Dermal benefits of topical D-ribose. Clin Cosmet Investig Dermatol. 2:151–152. 2009.PubMed/NCBI View Article : Google Scholar | |
|
Griffiths JC, Borzelleca JF and St Cyr J: Sub-chronic (13-week) oral toxicity study with D-ribose in Wistar rats. Food Chem Toxicol. 45:144–152. 2007.PubMed/NCBI View Article : Google Scholar | |
|
Ismail ZB, Abu-Baker N, Alzoubi K, Al-Zhgoul M, Al-Essa MK, Khlouf S, Al-Saleh A, Al-Omari B, Abu-Tayeh R, Shomaf M, et al: Evaluation of α-D-ribofuranose (D-ribose) toxicity after intravenous administration to rabbits. Hum Exp Toxicol. 31:820–829. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Sinatra ST and Caiazzo C: (D)-Ribose supplementation in the equine: Lack of effect on glycated plasma proteins suggesting safety in humans. J Am Coll Nutr. 34:108–112. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Peppa M, Uribarri J and Vlassara H: Glucose, advanced glycation end products, and diabetes complications: What is new and what works. Clin Diabetes. 21:186–187. 2003. | |
|
Yamamoto Y and Yamamoto H: Receptor for advanced glycation end-products-mediated inflammation and diabetic vascular complications. J Diabetes Investig. 2:155–157. 2011.PubMed/NCBI View Article : Google Scholar | |
|
Yu L, Chen Y, Xu Y, He T, Wei Y and He R: D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy. Aging (Albany NY). 11:4943–4969. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Iannuzzi C, Borriello M, Carafa V, Altucci L, Vitiello M, Balestrieri ML, Ricci G, Irace G and Sirangelo I: D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts. Biochim Biophys Acta. 1862:93–104. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Javed M, Ahmad MI, Javed H and Naseem S: D-ribose and pathogenesis of Alzheimer's disease. Mol Biol Rep. 47:2289–2299. 2020.PubMed/NCBI View Article : Google Scholar | |
|
Han C, Lu Y, Wei Y, Liu Y and He R: D-ribose induces cellular protein glycation and impairs mouse spatial cognition. PLoS One. 6(e24623)2011.PubMed/NCBI View Article : Google Scholar | |
|
Wei Y, Chen L, Chen J, Ge L and He RQ: Rapid glycation with D-ribose induces globular amyloid-like aggregations of BSA with high cytotoxicity to SH-SY5Y cells. BMC Cell Biol. 10(10)2009.PubMed/NCBI View Article : Google Scholar | |
|
Xu WL, von Strauss E, Qiu CX, Winblad B and Fratiglioni L: Uncontrolled diabetes increases the risk of Alzheimer's disease: A population-based cohort study. Diabetologia. 52:1031–1039. 2009.PubMed/NCBI View Article : Google Scholar | |
|
Chen L, Wei Y, Wang X and He R: Ribosylation rapidly induces alpha-synuclein to form highly cytotoxic molten globules of advanced glycation end products. PLoS One. 5(e9052)2010.PubMed/NCBI View Article : Google Scholar | |
|
Wei Y, Chen L and He RQ: D-ribosylated tau forms globular aggregates with high cytotoxicity. Alzheimer's Dementia. 5(395)2009.PubMed/NCBI View Article : Google Scholar | |
|
Wu B, Wei Y, Wang Y, Su T, Zhou L, Liu Y and He R: Gavage of D-Ribose induces Aβ-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice. Oncotarget. 6:34128–34142. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Wu B, Wang Y, Shi C, Chen Y, Yu L, Li J, Li W, Wei Y and He R: Ribosylation-derived advanced glycation end products induce tau hyperphosphorylation through brain-derived neurotrophic factor reduction. J Alzheimers Dis. 71:291–305. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Wang Y, Shi C, Chen Y, Yu L, Li Y, Wei Y, Li W and He R: Formaldehyde produced from d-ribose under neutral and alkaline conditions. Toxicol Rep. 6:298–304. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Han C, Lu Y, Wei Y, Wu B, Liu Y and He R: D-ribosylation induces cognitive impairment through RAGE-dependent astrocytic inflammation. Cell Death Dis. 5(e1117)2014.PubMed/NCBI View Article : Google Scholar | |
|
Gheith O, Farouk N, Nampoory N, Halim MA and Al-Otaibi T: Diabetic kidney disease: World wide difference of prevalence and risk factors. J Nephropharmacol. 5:49–56. 2015.PubMed/NCBI | |
|
Shevalye H, Maksimchyk Y, Watcho P and Obrosova IG: Poly(ADP-ribose) polymerase-1 (PARP-1) gene deficiency alleviates diabetic kidney disease. Biochim Biophys Acta. 1802:1020–1027. 2010.PubMed/NCBI View Article : Google Scholar | |
|
Shevalye H, Stavniichuk R, Xu W, Zhang J, Lupachyk S, Maksimchyk Y, Drel VR, Floyd EZ, Slusher B and Obrosova IG: Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model. Biochem Pharmacol. 79:1007–1014. 2010.PubMed/NCBI View Article : Google Scholar | |
|
Drel VR, Pacher P, Stevens MJ and Obrosova IG: Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells. Free Radic Biol Med. 40:1454–1465. 2006.PubMed/NCBI View Article : Google Scholar | |
|
Trevisan R and Dodesini AR: The hyperfiltering kidney in diabetes. Nephron. 136:277–280. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Zeni L, Norden AGW, Cancarini G and Unwin RJ: A more tubulocentric view of diabetic kidney disease. J Nephrol. 30:701–717. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Kumar Pasupulati A, Chitra PS and Reddy GB: Advanced glycation end products mediated cellular and molecular events in the pathology of diabetic nephropathy. Biomol Concepts. 7:293–309. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Yuan Y, Sun H and Sun Z: Advanced glycation end products (AGEs) increase renal lipid accumulation: A pathogenic factor of diabetic nephropathy (DN). Lipids Health Dis. 16(126)2017.PubMed/NCBI View Article : Google Scholar | |
|
Yamagishi S and Matsui T: Advanced glycation end products, oxidative stress and diabetic nephropathy. Oxid Med Cell Longev. 3:101–108. 2010.PubMed/NCBI View Article : Google Scholar | |
|
Hou FF, Ren H, Owen WF Jr, Guo ZJ, Chen PY, Schmidt AM, Miyata T and Zhang X: Enhanced expression of receptor for advanced glycation end products in chronic kidney disease. J Am Soc Nephrol. 5:1889–1896. 2004.PubMed/NCBI View Article : Google Scholar | |
|
Lapolla A, Fedele D, Seraglia R and Traldi P: The role of mass spectrometry in the study of non-enzymatic protein glycation in diabetes: An update. Mass Spectrom Rev. 25:775–797. 2006.PubMed/NCBI View Article : Google Scholar | |
|
Zhang N, Zhao S, Hong J, Li W and Wang X: Protective effects of kaempferol on D-ribose-induced mesangial cell injury. Oxid Med Cell Longev. 2019(7564207)2019.PubMed/NCBI View Article : Google Scholar | |
|
Hong J, Bhat OM, Li G, Dempsey SK, Zhang Q, Ritter JK, Li W and Li PL: Lysosomal regulation of extracellular vesicle excretion during d-ribose-induced NLRP3 inflammasome activation in podocytes. Biochim Biophys Acta Mol Cell Res. 1866:849–860. 2019.PubMed/NCBI View Article : Google Scholar |
