MicroRNAs as crucial mediators in the pharmacological activities of triptolide (Review)
- Authors:
- Kun Zhou
- Yinxia Chang
- Bo Han
- Rui Li
- Yanming Wei
-
Affiliations: Shanxi Institute of Energy, Taiyuan, Shanxi 030600, P.R. China, College of Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, P.R. China, College of Basic Medicine, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, P.R. China - Published online on: March 17, 2021 https://doi.org/10.3892/etm.2021.9930
- Article Number: 499
-
Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
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 |
|
Auyeung KK, Han QB and Ko JK: Astragalus membranaceus: A review of its protection against inflammation and gastrointestinal cancers. Am J Chin Med. 44:1–22. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Wang Z, Xia Q, Liu X, Liu W, Huang W, Mei X, Luo J, Shan M, Lin R, Zou D and Ma Z: Phytochemistry, pharmacology, quality control and future research of Forsythia suspensa (Thunb.) Vahl: A review. J Ethnopharmacol. 210:318–339. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Shi JF, Luo YY, Li JX, Luo RF, Chen L, Li J, Zhang JM and Fu CM: Research progress on anti-tumor effects and mechanisms of triptolide and its combined application. China J Chin Mater Med. 44:3391–3398. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Noel P, Von Hoff DD, Saluja AK, Velagapudi M, Borazanci E and Han M: Triptolide and its derivatives as cancer therapies. Trends Pharmacol Sci. 40:327–341. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Yan P and Sun X: Triptolide: A new star for treating human malignancies. J Cancer Res Ther. 14 (Suppl):S271–S275. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Huang G, Yuan K, Zhu Q, Zhang S, Lu Q, Zhu M, Sheng H, Yu R, Luo G and Xu A: Triptolide inhibits the inflammatory activities of neutrophils to ameliorate chronic arthritis. Mol Immunol. 101:210–220. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Huang SH, Lin GJ, Chu CH, Yu JC, Chen TW, Chen YW, Chien MW, Chu CC and Sytwu HK: Triptolide ameliorates autoimmune diabetes and prolongs islet graft survival in nonobese diabetic mice. Pancreas. 42:442–451. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Zheng CX, Chen ZH, Zeng CH, Qin WS, Li LS and Liu ZH: Triptolide protects podocytes from puromycin aminonucleoside induced injury in vivo and in vitro. Kidney Int. 74:596–612. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Yu H, Shi L, Zhao S, Sun Y, Gao Y, Sun Y and Qi G: Triptolide attenuates myocardial ischemia/reperfusion injuries in rats by inducing the activation of Nrf2/HO-1 defense pathway. Cardiovasc Toxicol. 16:325–335. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Xi C, Peng S, Wu Z, Zhou Q and Zhou J: Toxicity of triptolide and the molecular mechanisms involved. Biomed Pharmacother. 90:531–541. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Chen SR, Dai Y, Zhao J, Lin L and Wang Y and Wang Y: A mechanistic overview of triptolide and celestrol, natural products from Tripterygium wilfordii Hook F. Front Pharmacol. 9(104)2018.PubMed/NCBI View Article : Google Scholar | |
|
Yuan K, Li X, Lu Q, Zhu Q, Jiang H, Wang T, Huang G and Xu A: Application and mechanisms of triptolide in the treatment of inflammatory diseases-a review. Front Pharmacol. 10(1469)2019.PubMed/NCBI View Article : Google Scholar | |
|
Wei YM, Wang YH, Xue HQ, Luan ZH, Liu BW and Ren JH: Triptolide, A potential autophagy modulator. Chin J Integr Med. 25:233–240. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Jin W, Wang J, Liu CP, Wang HW and Xu RM: Structural basis for pri-miRNA recognition by Drosha. Mol Cell. 78:423–433. 2020.PubMed/NCBI View Article : Google Scholar | |
|
Olejniczak M, Kotowska-Zimmer A and Krzyzosiak W: Stress-induced changes in miRNA biogenesis and functioning. Cell Mol Life Sci. 75:177–191. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Dexheimer PJ and Cochella L: MicroRNAs: From mechanism to organism. Front Cell Dev Biol. 8(409)2020.PubMed/NCBI View Article : Google Scholar | |
|
Rupaimoole R and Slack FJ: MicroRNA therapeutics: Towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 16:203–222. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Liu Q, Wang W, Li F, Yu D, Xu C and Hu H: Triptolide inhibits breast cancer cell metastasis through inducing the expression of miR-146a, a negative regulator of Rho GTPase. Oncol Res. 27:1043–1050. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Peng A, Huang X, Liu R, Wang X and Zhuang J: Triptolide inhibits the inflammatory response of monocytes from rheumatoid arthritis patients by regulating miR-155. Chin J Cell Mol Immunol. 30:635–638. 2014.PubMed/NCBI | |
|
Feng Y, Zheng C, Zhang Y, Xing C, Cai W, Li R, Chen J and Duan Y: Triptolide inhibits preformed fibril-induced microglial activation by targeting the microRNA155-5p/SHIP1 pathway. Oxid Med Cell Longev. 2019(6527638)2019.PubMed/NCBI View Article : Google Scholar | |
|
Zhao X, Tang X, Yan Q, Song H, Li Z, Wang D, Chen H and Sun L: Triptolide ameliorates lupus via the induction of miR-125a-5p mediating Treg upregulation. Int Immunopharmacol. 71:14–21. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Yang Q, Sun M, Chen Y, Lu Y, Ye Y, Song H, Xu X, Shi S and Wang J: Triptolide protects podocytes from TGF-β-induced injury by preventing miR-30 downregulation. Am J Transl Res. 9:5150–5159. 2017.PubMed/NCBI | |
|
Wang SR, Chen X, Ling S, Ni RZ, Guo H and Xu JW: MicroRNA expression, targeting, release dynamics and early-warning biomarkers in acute cardiotoxicity induced by triptolide in rats. Biomed Pharmacother. 111:1467–1477. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Li SG, Shi QW, Yuan LY, Qin LP, Wang Y, Miao YQ, Chen Z, Ling CQ and Qin WX: C-Myc-dependent repression of two oncogenic miRNA clusters contributes to triptolide-induced cell death in hepatocellular carcinoma cells. J Exp Clin Cancer Res. 37(51)2018.PubMed/NCBI View Article : Google Scholar | |
|
Reno TA, Kim JY and Raz DJ: Triptolide inhibits lung cancer cell migration, invasion, and metastasis. Ann Thorac Surg. 100:1817–1825. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Kalla R, Ventham NT, Kennedy NA, Quintana JF, Nimmo ER, Buck AH and Satsangi J: MicroRNAs: New players in IBD. Gut. 64:504–517. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Michlewski G and Caceres JF: Post-transcriptional control of miRNA biogenesis. RNA. 25:1–16. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Saliminejad K, Khorram Khorshid HR, Soleymani Fard S and Ghaffari SH: An overview of microRNAs: Biology, functions, therapeutics, and analysis methods. J Cell Physiol. 234:5451–5465. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Vishnoi A and Rani S: miRNA biogenesis and regulation of diseases: An overview. Methods Mol Biol. 1509:1–10. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Yates LA, Norbury CJ and Gilbert RJ: The long and short of microRNA. Cell. 153:516–519. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Turner MJ and Slack FJ: Transcriptional control of microRNA expression in C elegans: Promoting better understanding. RNA Biol. 6:49–53. 2009.PubMed/NCBI View Article : Google Scholar | |
|
Kedde M, Strasser MJ, Boldajipour B, Oude Vrielink JA, Slanchev K, le Sage C, Nagel R, Voorhoeve PM, van Duijse J, Orom UA, et al: RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell. 131:1273–1286. 2007.PubMed/NCBI View Article : Google Scholar | |
|
Krol J, Loedige I and Filipowicz W: The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 11:597–610. 2010.PubMed/NCBI View Article : Google Scholar | |
|
Qi Y and Li J: Triptolide inhibits the growth and migration of colon carcinoma cells by down-regulation of miR-191. Exp Mol Pathol. 107:23–31. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Wu CW, Wang SG, Lin ML and Chen SS: Downregulation of miR-144 by triptolide enhanced p85α-PTEN complex formation causing S phase arrest of human nasopharyngeal carcinoma cells. Eur J Pharmacol. 855:137–148. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Chen M, Wang JM, Wang D, Wu R and Hou HW: Triptolide inhibits migration and proliferation of fibroblasts from ileocolonic anastomosis of patients with Crohn's disease via regulating the miR161/HSP70 pathway. Mol Med Rep. 19:4841–4851. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Qian K, Zhang L and Shi K: Triptolide prevents osteoarthritis via inhibiting hsa-miR-20b. Inflammopharmacology. 27:109–119. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Xue M, Cheng Y, Han F, Chang Y, Yang Y, Li X and Chen L, Lu Y, Sun B and Chen L: Triptolide attenuates renal tubular epithelial-mesenchymal transition via the miR-188-5p-mediated PI3K/AKT pathway in diabetic kidney disease. Int J Biol Sci. 14:1545–1557. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Han F, Wang S, Chang Y, Li C, Yang J, Han Z, Chang B, Sun B and Chen L: Triptolide prevents extracellular matrix accumulation in experimental diabetic kidney disease by targeting microRNA-137/Notch1 pathway. J Cell Physiol. 233:2225–2237. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Cao Y, Guo Y, Wang Y, Cao Y, Zong R, Huang C and Liu J: Drug-containing serum of Xinfeng capsules protect against H9C2 from death by enhancing miRNA-21 and inhibiting toll-like receptor 4/phosphorylated p-38 (p-p38)/p-p65 signaling pathway and proinflammatory cytokines expression. J Tradit Chin Med. 38:359–365. 2018.PubMed/NCBI | |
|
Cao YX, Huang D, Liu J, Zong RK, Wan L, Huang CB, Zhang WD and Wang Y: A novel chinese medicine, xinfeng capsule, modulates proinflammatory cytokines via regulating the toll-like receptor 4 (TLR4)/Mitogen-activated protein kinase (MAPK)/Nuclear Kappa B (NF-κB) signaling pathway in an adjuvant arthritis rat model. Med Sci Monit. 25:6767–6774. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Xu X, Tian L and Zhang Z: Triptolide inhibits angiogenesis in microvascular endothelial cells through regulation of miR-92a. J Physiol Biochem. 75:573–583. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Liang H, Zhang S and Li Z: Ginsenoside Rg3 protects mouse leydig cells against triptolide by downregulation of miR-26a. Drug Des Devel Ther. 13:2057–2066. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Mamoori A, Gopalan V and Lam AK: Role of miR-193a in cancer: Complexity and factors control the patterns of its expression. Curr Cancer Drug Targets. 18:618–628. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Svoronos AA, Engelman DM and Slack FJ: OncomiR or tumor suppressor? The duplicity of microRNAs in cancer. Cancer Res. 76:3666–3670. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Meng HT, Zhu L, Ni WM, You LS, Jin J and Qian WB: Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-kappaB activity and miR-16-1*. Acta Pharmacol Sin. 32:503–511. 2011.PubMed/NCBI View Article : Google Scholar | |
|
Xiang W, Yang CY and Bai L: Mcl-1 inhibiton in cancer treatment. Onco Targets Ther. 11:7301–7314. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Chen Z, Sangwan V, Banerjee S, Mackenzie T, Dudeja V, Li X, Wang H, Vickers SM and Saluja AK: miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death. Mol Cancer. 12(105)2013.PubMed/NCBI View Article : Google Scholar | |
|
Roufayel R and Kadry S: Molecular chaperone HSP70 and key regulators of apoptosis - a review. Curr Mol Med. 19:315–325. 2019.PubMed/NCBI View Article : Google Scholar | |
|
MacKenzie TN, Mujumdar N, Banerjee S, Sangwan V, Sarver A, Vickers S, Subramanian S and Saluja AK: Triptolide induces the expression of miR-142-3p: A negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation. Mol Cancer Ther. 12:1266–1275. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Hang S, Wang X and Li H: Triptolide inhibits viability and migration while promotes apoptosis in nephroblastoma cells by regulation of miR-193b-3p. Exp Mol Pathol. 108:80–88. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Zhang H, Li H, Liu Z, Ge A, Guo E, Liu S and Chen Z: Triptolide inhibits the proliferation and migration of medulloblastoma Daoy cells by upregulation of microRNA-138. J Cell Biochem. 119:9866–9877. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Yao C, Li H and Zhang W: Triptolide inhibits benign prostatic epithelium viability and migration and induces apoptosis via upregulation of microRNA-218. Int J Immunopathol Pharmacol. 32(2058738418812349)2018.PubMed/NCBI View Article : Google Scholar | |
|
Liu Q, Wang W, Yang X, Zhao D, Li F and Wang H: miRNA-146a inhibits cell migration and invasion by targeting RhoA in breast cancer. Oncol Rep. 36:189–196. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Hu H, Tang J, Liu C and Cen Y: miR-23b promotes the migration of keratinocytes through downregulating TIMP3. J Surg Res. 254:102–109. 2020.PubMed/NCBI View Article : Google Scholar | |
|
Wang J, Zhou F, Yin L, Zhao L, Zhang Y and Wang J: MicroRNA-199b targets the regulation of ZEB1 expression to inhibit cell proliferation, migration and invasion in non-small cell lung cancer. Mol Med Rep. 16:5007–5014. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Charles S, Raj V, Arokiaraj J and Mala K: Caveolin1/protein arginine methyltransferase1/sirtuin1 axis as a potential target against endothelial dysfunction. Pharmacol Res. 119:1–11. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Philips BJ, Kumar A, Burki S, Ryan JP, Noda K and D'Cunha J: Triptolide-induced apoptosis in non-small cell lung cancer via a novel miR204-5p/Caveolin-1/Akt-mediated pathway. Oncotarget. 11:2793–2806. 2020.PubMed/NCBI View Article : Google Scholar | |
|
Cao Y: Adipocyte and lipid metabolism in cancer drug resistance. J Clin Invest. 129:3006–3017. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Gomes BC, Rueff J and Rodrigues AS: MicroRNAs and cancer drug resistance. Methods Mol Biol. 1395:137–162. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Pfeffer SR, Yang CH and Preffer LM: The role of miR-21 in cancer. Drug Dev Res. 76:270–277. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Li X, Zang A, Jia Y, Zhang J, Fan W, Feng J, Duan M, Zhang L, Huo R, Jiao J and Zhu X: Triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through PTEN by targeting miR-21. Mol Med Rep. 13:2763–2768. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Li H, Hui L, Xu W, Shen H, Chen Q, Long L and Zhu X: Triptolide modulates the sensitivity of K562/A02 cells to adriamycin by regulating miR-21 expression. Pharm Biol. 50:1233–1240. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Wang R, Ma X, Su S and Liu Y: Triptolide antagonized the cisplatin resistance in human ovarian cancer cell line A2780/CP70 via hsa-mir-6751. Future Med Chem. 10:1947–1955. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Huang X, Yang M and Jin J: Triptolide enhances the sensitivity of multiple myeloma cells to dexamethasone via microRNAs. Leuk Lymphoma. 53:1188–1195. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Jiang C, Fang X, Zhang H, Wang X, Li M, Jiang W, Tian F, Zhu L and Bian Z: Triptolide inhibits the growth of osteosarcoma by regulating microRNA-181a via targeting PTEN gene in vivo and vitro. Tumour Biol. 39(1010428317697556)2017.PubMed/NCBI View Article : Google Scholar | |
|
Jiang J, Song X, Yang J, Lei K, Ni Y, Zhou F and Sun L: Triptolide inhibits proliferation and migration of human neuroblastoma SH-SY5Y cells by upregulating MicroRNA-181a. Oncol Res. 26:1235–1243. 2018.PubMed/NCBI View Article : Google Scholar | |
|
O'Connell RM, Rao DS and Baltimore D: microRNA regulation of inflammatory responses. Annu Rev Immunol. 30:295–312. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Mahesh G and Biswas R: miRNA-155: A master regulator of inflammation. J Interferon Cytokine Res. 39:321–330. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Matta R, Wang X, Ge H, Ray W, Nelin LD and Liu Y: Triptolide induces anti-inflammatory cellular responses. Am J Transl Res. 1:267–282. 2009.PubMed/NCBI | |
|
Tang H, Mao J, Ye X, Zhang F, Kerr WG, Zheng T and Zhu Z: SHIP-1, a target of miR-155, regulates endothelial cell responses in lung fibrosis. FASEB J. 34:2011–2023. 2020.PubMed/NCBI View Article : Google Scholar | |
|
Wu R, Li Y, Guo Z, Gong J, Zhu W, Li N and Li J: Triptolide ameliorates ileocolonic anastomosis inflammation in IL-10 deficient mice by mechanism involving suppression of miR-155/SHIP-1 signaling pathway. Mol Immunol. 56:340–346. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Hou HW, Wang JM, Wang D, Wu R and Ji ZL: Triptolide exerts protective effects against fibrosis following ileocolonic anastomosis by mechanisms involving the miR-16-1/HSP70 pathway in IL-10-deficient mice. Int J Mol Med. 40:337–346. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Lee GR: The balance of Th17 versus Treg cells in autoimmunity. Int J Mol Sci. 19(730)2018.PubMed/NCBI View Article : Google Scholar | |
|
Li XY, Wang SS, Han Z, Han F, Chang YP, Yang Y, Xue M, Sun B and Chen LM: Triptolide restores autophagy to alleviate diabetic renal fibrosis through the miR-141-3p/PTEN/Akt/mTOR pathway. Mol Ther Nucleic Acids. 9:48–56. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Jiang CB, Wei MG, Tu Y, Zhu H, Li CQ, Jing WM and Sun W: Triptolide attenuates podocyte injury by regulating expression of miRNA-344b-3p and miRNA-30b-3p in rats with adriamycin-induced nephropathy. Evid Based Complement Alternat Med. 2015(107814)2015.PubMed/NCBI View Article : Google Scholar | |
|
Ignarski M, Islam R and Muller RU: Long non-coding RNAs in kidney disease. Int J Mol Sci. 20(3276)2019.PubMed/NCBI View Article : Google Scholar | |
|
Bonauer A, Carmona G, Iwasaki M, Mione M, Koyanagi M, Fischer A, Burchfield J, Fox H, Doebele C, Ohtani K, et al: MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science. 324:1710–1713. 2009.PubMed/NCBI View Article : Google Scholar | |
|
Zhang L, Zhou M, Qin G, Weintraub NL and Tang Y: miR-92a regulates viability and angiogenesis of endothelial cells under oxidative stress. Biochem Biophys Res Commun. 446:952–958. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Marrone AK, Beland FA and Pogribny IP: The role for microRNAs in drug toxicity and in safety assessment. Expert Opin Drug Metab Toxicol. 11:601–611. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Ichihara S, Li P, Mise N, Suzuki Y, Izuoka K, Nakajima T, Gonzalez F and Ichihara G: Ablation of aryl hydrocarbon receptor promotes angiotensin II-induced cardiac fibrosis through enhanced c-Jun/HIF-1α signaling. Arch Toxicol. 93:1543–1553. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Nam HS, Hwang KS, Jeong YM, Ryu JI, Choi TY, Bae MA, Son WC, You KH, Son HY and Kim CH: Expression of miRNA-122 induced by liver toxicants in Zebrafish. Biomed Res Int. 2016(1473578)2016.PubMed/NCBI View Article : Google Scholar | |
|
Vliegenthart ADB, Wei C, Buckley C, Berends C, de Potter CMJ, Schneemann S, Del Pozo J, Tucker C, Mullins JJ, Webb DJ and Dear JW: Characterization of triptolide-induced hepatotoxicity by imaging and transcriptomics in a novel Zebrafish model. Toxicol Sci. 159:380–391. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Cheng B, Zhu Q, Lin W and Wang L: MicroRNA-122 inhibits epithelial-mesenchymal transition of hepatic stellate cells induced by the TGF-β1/Smad signaling pathway. Exp Ther Med. 17:284–290. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Yuan Y, Tong L and Wu S: microRNA and NF-kappa B. Adv Exp Med Biol. 887:157–170. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Ichikawa D, Komatsu S, Konishi H and Otsuji E: Circulating microRNA in digestive tract cancers. Gastroenterology. 1421074–1078. (e1071)2012.PubMed/NCBI View Article : Google Scholar | |
|
Titov DV, Gilman B, He QL, Bhat S, Low WK, Dang Y, Smeaton M, Demain AL, Miller PS, Kugel JF, et al: XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nat Chem Biol. 7:182–188. 2011.PubMed/NCBI View Article : Google Scholar | |
|
Chauhan AK, Li P, Sun Y, Wani G, Zhu Q and Wani AA: Spironolactone-induced XPB degradtion requires TFIIH integrity and ubiquitin-selective segregase VCP/p97. Cell Cycle. 20:81–95. 2021.PubMed/NCBI View Article : Google Scholar | |
|
He QL, Titov DV, Li J, Tan M, Ye Z, Zhao Y, Romo D and Liu JO: Covalent modification of a cysteine residue in the XPB subunit of the general transcription factor TFIIH through single epoxide cleavage of the transcription inhibitor triptolide. Angew Chem Int Ed Engl. 54:1859–1863. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Manzo SG, Zhou ZL, Wang YQ, Marinello J, He JX, Li YC, Ding J, Capranico G and Miao ZH: Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II. Cancer Res. 72:5363–5373. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Abascal-Palacios G, Ramsay EP, Beuron F, Morris E and Vannini A: Structural basis of RNA polymerase III transcription initiation. Nature. 553:301–306. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Liang X, Xie R, Su J, Ye B, Wei S, Liang Z, Bai R, Chen Z, Li Z and Gao X: Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis. J Exp Clin Cancer Res. 38(217)2019.PubMed/NCBI View Article : Google Scholar | |
|
Yamagishi M and Uchimaru K: Targeting EZH2 in cancer therapy. Curr Opin Oncol. 29:375–381. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Ihira K, Dong P, Xiong Y, Watari H, Konno Y, Hanley SJ, Noguchi M, Hirata N, Suizu F, Yamada T, et al: EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis. Oncotarget. 8:13509–13520. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Tamgue O, Chai CS, Hao L, Zambe JC, Huang WW, Zhang B, Lei M and Wei YM: Triptolide inhibits histone methyltransferase EZH2 and modulates the expression of its target genes in prostate cancer cells. Asian Pac J Cancer Prev. 14:5663–5669. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Akkoc Y and Gozuacik D: MicroRNAs as major regulators of the autophagy pathway. Biochim Biophys Acta Mol Cell Res 1867: Kappa B, 2020. | |
|
Gibbings D, Mostowy S, Jay F, Schwab Y, Cossart P and Voinnet O: Selective autophagy degrades DICER and AGO2 and regulates miRNA activity. Nat Cell Biol. 14:1314–1321. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Peng K, Li X, Wu C, Wang Y, Yu J, Zhang J, Gao Q, Zhang W, Zhang Q, Fan Y, et al: Derivation of haploid trophoblast stem cells via conversion in vitro. iScience. 11:508–518. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Wang H, Zhang W, Yu J, Wu C, Gao Q, Li X, Li Y, Zhang J, Tian Y, Tan T, et al: Genetic screening and multipotency in rhesus monkey haploid neural progenitor cells. Development. 145(dev160531)2018.PubMed/NCBI View Article : Google Scholar | |
|
Huang Y, Zhu N, Chen T, Chen W, Kong J, Zheng W and Ruan J: Triptolide suppressed the microglia activation to improve spinal cord injury through miR-96/IKKβ/NF-κB pathway. Spine (Phila Pa 1976). 44:E707–E714. 2019.PubMed/NCBI View Article : Google Scholar |
