Correlations between periodontal indices and osteoporosis

Preda,Smaranda Adelina; Comanescu,Maria Cristina; Albulescu,Dana Maria; Dascălu,Ionela Teodora; Camen,Adrian; Cumpătă,Cristian Niky; Perlea,Paula; Bugălă,Narcis Mihăiță; Stoica,Elena Loredana; Gheorghiță,Lelia Mihaela; Diaconu,Oana Andreea; Tuculina,Mihaela Jana

doi:10.3892/etm.2022.11179

Correlations between periodontal indices and osteoporosis

Authors:
- Smaranda Adelina Preda
- Maria Cristina Comanescu
- Dana Maria Albulescu
- Ionela Teodora Dascălu
- Adrian Camen
- Cristian Niky Cumpătă
- Paula Perlea
- Narcis Mihăiță Bugălă
- Elena Loredana Stoica
- Lelia Mihaela Gheorghiță
- Oana Andreea Diaconu
- Mihaela Jana Tuculina
View Affiliations

Affiliations: Department of Odontotherapy, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Anatomy, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Orthodontics, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Maxillo‑Facial Surgery, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Maxillo‑Facial Surgery, Faculty of Dental Medicine, ‘Titu Maiorescu’ University, RO‑031593 Bucharest, Romania, Department of Endodontics, Faculty of Dental Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 010221 Bucharest, Romania, Department of Biostatistics, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Dermatology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Published online on: February 1, 2022 https://doi.org/10.3892/etm.2022.11179
Article Number: 254

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

In the pathogenesis of chronic periodontitis, there are general systemic factors which play a major role, such as osteoporosis, with menopause as the most common etiological factor, and other pathological determining conditions for osteoporosis as well (ovary, thyroid and malignant tumors). The aim of the present study was to assess the correlations between periodontal indices and osteoporosis. The study was performed on 35 patients with periodontal disease aged between 45 and 79 years. These patients were divided into two groups: a study group with osteoporosis and periodontal disease (n=25) and a control group with periodontal disease (n=10) only. The periodontal assessment included community periodontal index (CPI), gingival inflammation index (GI), plaque index (PI), body mass index (BMI), bone mineral density (BMD), tooth mobility and tooth loss. Osteoporosis was assessed by dual‑energy X‑ray absorptiometry. Results were statistically analyzed with Microsoft Excel software and XLSTAT. The results showed that patients in the study group had higher values of periodontal indices, and a highly significant inverse correlation was observed between the CPI and the tooth loss. Inverse correlations between BMI and tooth mobility, as well as BMI and CPI were determined for the study group. In conclusion, the positive association between BMD and GI shows that the gingival index can be a predictive factor in the occurrence of osteoporosis.

View Figures

View References

1	Preda SA, Nechita F, Comanescu MC, Albulescu DM, Tuculina MJ, Docea AD, Burada E, Vasile RC and Mitroi M: Evaluation of bone turnover and DXA markers in premature ovarian failure. Rev Chim (Bucharest). 70:2054–2057. 2019.
2	Popescu M, Carsote M, Ghemigian A, Ionovici N, Calborean V, Dinescu VC and Albulescu DM: Calcifediol concentration vs circulating thyrotropin and free thyroxine in human blood of postmenopausal women. Rev Chim. 69:2089–2091. 2018.
3	Albu CV, Pădureanu V, Boldeanu MV, Bumbea AM, Enescu AS, Albulescu DM, Silosi CA and Enescu A: Vascular neurocognitive disorders and the vascular risk factors. J Mind Med Sci. 5:7–15. 2018.
4	Albulescu DM, Ionovici N, Moldovan HR, Demetrian AD, Bala VS, Constantin C, Bumbea AM, Panus C and Albu VC: Muscle metastases from cervical carcinoma-case report. Rom J Morphol Embryol. 58:545–551. 2017.PubMed/NCBI
5	Richa YR, Puranik MP and Shrivastava A: Association between osteoporosis and periodontal disease among postmenopausal Indian women. J Invest Clin Dent. 8:2017.PubMed/NCBI View Article : Google Scholar
6	Grocholewicz K and Bohatyrewicz A: Oral health and bone mineral density in postmenopausal women. Arch Oral Biol. 57:245–251. 2012.PubMed/NCBI View Article : Google Scholar
7	Phipps KR, Chan BK, Madden TE, Geurs NC, Reddy MS, Lewis CE and Orwoll ES: Longitudinal study of bone density and periodontal disease in men. J Dent Res. 86:1110–1114. 2007.PubMed/NCBI View Article : Google Scholar
8	Jepsen S, Caton JG, Albandar JM, Bissada NF, Bouchard P, Cortellini P, Demirel K, de Sanctis M, Ercoli C, Fan J, et al: Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World workshop on the classification of periodontal and peri-implant diseases and conditions. J Periodontol. 89 (Suppl 1):S237–S248. 2018.PubMed/NCBI View Article : Google Scholar
9	Esfahanian V and Shamami MS and Shamami MS: Relationship between osteoporosis and periodontal disease: Review of the literature. J Dent (Tehran). 9:256–264. 2012.PubMed/NCBI
10	Wang CJ and Mccauley LK: Osteoporosis and periodontitis. Curr Osteoporos Rep. 14:284–291. 2016.PubMed/NCBI View Article : Google Scholar
11	Wactawski-Wende J: Periodontal diseases and osteoporosis: Association and mechanisms. Ann Periodontol. 6:197–208. 2001.PubMed/NCBI View Article : Google Scholar
12	Guiglia R, Di Fede O, Lo Russo L, Sprini D, Rini GB and Campisi G: Osteoporosis, jawbones and periodontal disease. Med Oral Patol Oral Cir Bucal. 18:e93–e99. 2013.PubMed/NCBI View Article : Google Scholar
13	Martinez-Maestre MA, Gonzalez-Cejudo C, Machuca G, Torrejon R and Castelo-Branco C: Periodontitis and osteoporosis: A systematic review. Climacteric. 13:523–529. 2010.PubMed/NCBI View Article : Google Scholar
14	Tonetti MS, Greenwell H and Kornman KS: Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. J Periodontol. 89 (Suppl 1):S159–S172. 2018.PubMed/NCBI View Article : Google Scholar
15	Löe H: The gingival index, the plaque index and the retention index systems. J Periodontol. 38: (Suppl):S610–S616. 1967.PubMed/NCBI View Article : Google Scholar
16	Al Habashneh R, Azar W, Shaweesh A and Khader Y: The relationship between body mass index and periodontitis among postmenopausal women. Obes Res Clin Pract. 10:15–23. 2016.PubMed/NCBI View Article : Google Scholar
17	Al-Zahrani MS, Bissada NF and Borawski EA: Obesity and periodontal disease in young, middle-aged, and older adults. J Periodontol. 74:610–615. 2003.PubMed/NCBI View Article : Google Scholar
18	Kongstad J, Hvidtfeldt UA, Gronbaek M, Stoltze K and Holmstrup P: The relationship between body mass index and periodontitis in the copenhagen city heart study. J Periodontol. 80:1246–1253. 2009.PubMed/NCBI View Article : Google Scholar
19	Khader YS, Bawadi HA, Haroun TF, Alomari M and Tayyem RF: The association between periodontal disease and obesity among adults in Jordan. J Clin Periodontol. 36:18–24. 2009.PubMed/NCBI View Article : Google Scholar
20	Ayeda MS, Alsharif AF, Divakar DD, Jhugroo C, Alosaimi B and Mustafa M: Evaluating the possible association between systemic osteoporosis and periodontal disease progression in postmenopausal women. Dis Mon. 65:193–215. 2019.PubMed/NCBI View Article : Google Scholar
21	Yoshihara A, Seida Y, Hanada N and Miyazaki H: A longitudinal study of the relationship between periodontal disease and bone mineral density in community-dwelling older adults. J Clin Periodontol. 31:680–684. 2004.PubMed/NCBI View Article : Google Scholar
22	Famili P, Cauley J, Suzuki JB and Weyant R: Longitudinal study of periodontal disease and edentulism with rates of bone loss in older women. J Periodontol. 76:11–15. 2005.PubMed/NCBI View Article : Google Scholar
23	Pereira FM, Rodrigues VP, de Oliveira AE, Brito LM and Lopes FF: Association between periodontal changes and osteoporosis in postmenopausal women. Climacteric. 18:311–315. 2015.PubMed/NCBI View Article : Google Scholar
24	Mashalkar VN, Suragimath G, Zope SA and Varma SA: A cross-sectional study to assess and correlate osteoporosis and periodontitis among postmenopausal women: A dual energy X-ray absorptiometry study. J Midlife Health. 9:2–7. 2018.PubMed/NCBI View Article : Google Scholar
25	Suresh S, Kumar TS, Saraswathy PK and Pani Shankar KH: Periodontitis and bone mineral density among pre and post menopausal women: A comparative study. J Indian Soc Periodontol. 14:30–34. 2010.PubMed/NCBI View Article : Google Scholar
26	Shum I, Leung PC, Kwok A, Corbet EF, Orwoll ES, Phipps KR and Jin L: Periodontal conditions in elderly men with and without osteoporosis or osteopenia. J Periodontol. 81:1396–1402. 2010.PubMed/NCBI View Article : Google Scholar
27	Andreescu CF, Mihai LL, Răescu M, Tuculina MJ, Cumpata CN and Ghergic DL: Age influence on periodontal tissues: A histological study. Rom J Morphol Embryol. 54 (Suppl 3):S811–S815. 2013.PubMed/NCBI
28	Chang WP, Chang WC, Wu MS, Pai JT, Guo YC, Chen KC, Liu ME, Chiu WT and Hung KS: Population-based 5-year follow-up study in Taiwan of osteoporosis and risk of periodontitis. J Periodontol. 85:e24–e30. 2014.PubMed/NCBI View Article : Google Scholar
29	Juluri R, Prashanth E, Gopalakrishnan D, Kathariya R, Devanoorkar A, Viswanathan V and Romanos GE: Association of postmenopausal osteoporosis and periodontal disease: A double-blind case-control study. J Int Oral Health. 7:119–123. 2015.PubMed/NCBI
30	Renvert S, Berglund J, Persson RE and Persson GR: Osteoporosis and periodontitis in older subjects participating in the Swedish National survey on aging and care (SNAC-Blekinge). Acta Odontol Scand. 69:201–207. 2011.PubMed/NCBI View Article : Google Scholar
31	Inagaki K, Kurosu Y, Yoshinari N, Noguchi T, Krall EA and Garcia RI: Efficacy of periodontal disease and tooth loss to screen for low bone mineral density in Japanese women. Calcif Tissue Int. 77:9–14. 2005.PubMed/NCBI View Article : Google Scholar
32	Ronderos M, Jacobs DR, Himes JH and Pihlstrom BLJ: Associations of periodontal disease with femoral bone mineral density and estrogen replacement therapy: Cross-sectional evaluation of US adults from NHANES III. J Clin Periodontol. 27:778–786. 2000.PubMed/NCBI View Article : Google Scholar
33	Duncea I, Pop D and Georgescu C: Gingival recession in postmenopausal women with and without osteoporosis. Clujul Med. 86:69–73. 2013.PubMed/NCBI
34	Bullon P, Goberna B, Guerrero JM, Segura JJ, Perez-Cano R and Martinez-Sahuquillo A: Serum, saliva, and gingival crevicular fluid osteocalcin: Their relation to periodontal status and bone mineral density in postmenopausal women. J Periodontol. 76:513–519. 2005.PubMed/NCBI View Article : Google Scholar
35	Bertulucci Lde A, Pereira FM, de Oliveira AE, Brito LM and Lopes FF: Periodontal disease in women in post-menopause and its relationship with osteoporosis. Rev Bras Ginecol Obstet. 34:563–567. 2012.PubMed/NCBI View Article : Google Scholar : (In Portuguese).
36	Alves RC, Félix SA, Rodriguez-Archilla A, Oliveira P, Brito J and Dos Santos JM: Relationship between menopause and periodontal disease: A cross-sectional study in a Portuguese population. Int J Clin Exp Med. 8:11412–11419. 2015.PubMed/NCBI
37	Bechir ES, Voinea-Georgescu R, Tuculina MJ, Dascălu IT, Popescu DM, Cojocaru M, Gheorghiță LM, Cumpata CN, Raescu M and Gheorghe AC: Clinical-statistical study on the use of a magnesium-terpene-based substance in polymeric trays for periodontal treatment. Revista de Mase Plastice. 56:964–967. 2019.
38	Bechir ES, Tuculina MJ, Carsote M, Bătăiosu M, Raescu M and Cumpata CN: Clinical data on transitory teriparatide-related hypercalcemia in daily practice treatment for severe menopausal osteoporosis. Rev Chim. 70:3176–3179. 2019.