Open Access

Monomeric C‑reactive protein level is associated with osteoarthritis

  • Authors:
    • Yulin Liang
    • Ke Xu
    • Wenguang Liu
    • Xiaoling Liu
    • Ping Yuan
    • Peng Xu
    • Haiyun Li
  • View Affiliations

  • Published online on: February 11, 2022     https://doi.org/10.3892/etm.2022.11206
  • Article Number: 277
  • Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteoarthritis (OA) is a chronic joint disease characterized by articular cartilage degeneration and secondary bone hyperplasia. C‑reactive protein (CRP) is an acute‑phase protein that is widely used as a marker of inflammation. Elevated plasma levels of CRP are commonly observed in patients with OA during the acute phase. Current evidence indicates that CRP dissociating into a monomeric form (mCRP) is the main functional conformation at inflammatory loci. However, it remains unclear whether mCRP is associated with OA and whether mCRP can be used as a biomarker for its pathogenesis. In the present study, the concentration of CRP, mCRP and anti‑mCRP autoantibody were detected by performing ELISA. The levels of plasma CRP, mCRP and anti‑mCRP autoantibody between healthy subjects and patients with OA were compared. The results revealed that plasma mCRP was strongly associated with OA, while mCRP autoantibodies exhibited little correlation with this condition. Additionally, it was identified that the plasma mCRP levels in Kellgren‑Lawrence (KL) grade 4 patients were significantly higher than in those with KL grade 3. Thus, it was revealed in the present study that plasma level of mCRP is associated with OA, which may directly reflect the disease degree of patients. Therefore, mCRP may be a potential indicator that can be used to monitor the disease activity and evaluate the efficiency of OA therapy.
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April-2022
Volume 23 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liang Y, Xu K, Liu W, Liu X, Yuan P, Xu P and Li H: Monomeric C‑reactive protein level is associated with osteoarthritis. Exp Ther Med 23: 277, 2022.
APA
Liang, Y., Xu, K., Liu, W., Liu, X., Yuan, P., Xu, P., & Li, H. (2022). Monomeric C‑reactive protein level is associated with osteoarthritis. Experimental and Therapeutic Medicine, 23, 277. https://doi.org/10.3892/etm.2022.11206
MLA
Liang, Y., Xu, K., Liu, W., Liu, X., Yuan, P., Xu, P., Li, H."Monomeric C‑reactive protein level is associated with osteoarthritis". Experimental and Therapeutic Medicine 23.4 (2022): 277.
Chicago
Liang, Y., Xu, K., Liu, W., Liu, X., Yuan, P., Xu, P., Li, H."Monomeric C‑reactive protein level is associated with osteoarthritis". Experimental and Therapeutic Medicine 23, no. 4 (2022): 277. https://doi.org/10.3892/etm.2022.11206