Rare and unusual benign tumors of the sinonasal tract and pharynx: Case series and literature review

Mocanu,Horia; Mocanu,Adela-Ioana; Moldovan,Cosmin; Soare,Ioana; Postolache,Paraschiva A.; Nechifor,Alexandru

doi:10.3892/etm.2022.11263

Rare and unusual benign tumors of the sinonasal tract and pharynx: Case series and literature review

Authors:
- Horia Mocanu
- Adela-Ioana Mocanu
- Cosmin Moldovan
- Ioana Soare
- Paraschiva A. Postolache
- Alexandru Nechifor
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Affiliations: Department of Ear, Nose and Throat and Head and Neck, Faculty of Medicine, Titu Maiorescu University, 031593 Bucharest, Romania, Department of Ear, Nose and Throat and Head and Neck, Polimed Medical Center, 040067 Bucharest, Romania, Department of Surgery, Faculty of Medicine, Titu Maiorescu University of Bucharest, 031593 Bucharest, Romania, Department of Geriatrics, Faculty of Medicine, Titu Maiorescu University of Bucharest, 031593 Bucharest, Romania, Medical Department, Faculty of Medicine, ̔Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iași, Romania, Medical Clinical Department, Faculty of Medicine and Pharmacy, ̔Dunărea de Jos’ University, 800008 Galați, Romania
Published online on: March 16, 2022 https://doi.org/10.3892/etm.2022.11263
Article Number: 334
Copyright: © Mocanu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

There are a number of benign tumors of the nose and pharynx that are seldomly reported in literature but that can sometimes prove difficult to treat and extremely important for differential diagnosis. The present study presents cases of rare benign tumors localized in the pharynx, nasal and sinus cavities, as well as reviews of literature and historical references for each type of tumor. Unilateral nasal hemangioma in a 72‑year‑old male which, although not a rare pathology, raised problems due to auto‑resection of the tumor. The surgeon was able to pull it out with ease without bleeding; it is possible that the mass would have eventually fallen out. Pilomatrixoma is a relatively uncommon ectodermal benign tumor of the skin derived from hair matrix cells. Surgical resection is curative but recurrence is possible (≤5% risk). The presented case is of a 26‑year‑old female with a pilomatrixoma of the left cheek who, for aesthetic reasons, refused a classical external surgical approach. Trans‑oral resection was performed, which proved feasible but laborious and prone to recurrence. Inverted Schneiderian papilloma is a rare benign tumor of the nasal and sinus cavities with increased potential for invasion, recurrence and malignant transformation compared with other types of papilloma and other benign tumors of the area. The tumor represents 0.5‑4.0% of all nasal tumors and has been described under different names, such as villiform cancer and cylindrical/transitional papilloma. The present study reports a rare case of bilateral papilloma in a 68‑year‑old male. He presented with bilateral evolving nasal obstruction and hyposmia. Following surgery, the patient was treated by a multidisciplinary team and followed by a respiratory rehabilitation program.

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1	Neagu A, Mocanu AI, Bonciu A, Coadă G and Mocanu H: Prevalence of GJB2 gene mutations correlated to presence of clinical and environmental risk factors in the etiology of congenital sensorineural hearing loss of the Romanian population. Exp Ther Med. 21(612)2021.PubMed/NCBI View Article : Google Scholar
2	Batsakis JG and Rice DH: The pathology of head and neck tumors: Vasoformative tumors, part 9A. Head Neck Surg. 3:231–239. 1981.PubMed/NCBI View Article : Google Scholar
3	Hoffmann DF and Israel J: Intraosseous frontal hemangioma. Head and Neck. 12:160–163. 1990.PubMed/NCBI View Article : Google Scholar
4	Takeda K, Takeda Y and Hashimoto M: Intraosseous hemangioma of the inferior turbinate. Case Rep Med. 2010(409429)2010.PubMed/NCBI View Article : Google Scholar
5	Arhontaki M, Stamou AK, Hajioannou JK, Kalomenoupoulou M, Korkolis DP and Kyrmizakis DE: Cavernous hemangioma of the left nasal cavity. Acta Otolaryngol Ital. 28:309–311. 2008.PubMed/NCBI
6	Danielson-Cohen A, Lin SJ, Hughes CA, An YH and Maddalozzo J: Head and neck pilomatrixoma in children. Arch Otolaryngol Head Neck Surg. 127:1481–1483. 2001.PubMed/NCBI View Article : Google Scholar
7	Julian CG and Bowers PW: A clinical review of 209 pilomatricomas. J Am Acad Dermatol. 39 (2 Pt 1):191–195. 1998.PubMed/NCBI View Article : Google Scholar
8	Forbis R Jr and Helwig EB: Pilomatrixoma (calcifying epithelioma). Arch Dermatol. 83:606–617. 1961.PubMed/NCBI View Article : Google Scholar
9	Gongidi P, Meshekow J, Holdbrook T and Germaine P: Giant pilomatrixoma presenting in the posterior thorax, a rare location and the largest described. Case Rep Radiol. 2015(590742)2015.PubMed/NCBI View Article : Google Scholar
10	Knight PJ and Reinerm CB: Superficial lumps in children: What, when and why? Pediatrics. 72:147–153. 1983.PubMed/NCBI
11	Lee EJ, Kim AY, Lee EM, Park JK and Jeong KS: Malignant pilomatricoma in a young dog. Acta Vet. 66:556–561. 2016.
12	Vrabec PD: The inverted schneiderian papilloma: A 25-year study. Laryngoscope. 104 (5 Pt 1):582–604. 1994.PubMed/NCBI View Article : Google Scholar
13	Brown B: The papillomatous tumours of the nose. J Laryngol Otol. 78:889–905. 1964.PubMed/NCBI View Article : Google Scholar
14	Cheung FM, Lau TW, Cheung LK, Li AS, Chow SK and Lo AW: Schneiderian papillomas and carcinomas: A retrospective study with special reference to p53 and p16 tumour suppressor gene expression and association with HPV. Ear Nose Throat J. 89:E5–E12. 2010.PubMed/NCBI View Article : Google Scholar
15	von Buchwald C and Bradley PJ: Risks of malignancy in inverted papilloma of the nose and paranasal sinuses. Curr Opin Otolaryng Head Neck Surg. 15:95–98. 2007.PubMed/NCBI View Article : Google Scholar
16	Eggers G, Mühling J and Hassfeld S: Inverted papilloma of paranasal sinuses. J Craniomaxillofac Surg. 35:21–29. 2007.PubMed/NCBI View Article : Google Scholar
17	Suarez PA, Adler-Storthz K, Luna MA, El-Naggar AK, Abdul-Karim FW and Batsakis JG: Papillary squamous cell carcinomas of the upper aerodigestive tract: A clinicopathologic and molecular study. Head Neck. 22:360–368. 2000.PubMed/NCBI View Article : Google Scholar
18	Jagtap SV, Nikumbh DB, Chavan SH, Jain G and Havale AD: Inverted sinonasal schneiderian papilloma with malignant transformation. J Clin Diagn Res. 5:1275–1277. 2011.
19	Batsakis JG and Suarez P: Schneiderian papillomas and carcinomas: A review. Adv Anat Pathol. 8:53–64. 2001.PubMed/NCBI View Article : Google Scholar
20	Perez-Ordonez B: Hamartomas, papillomas and adenocarcinomas of the sinonasal tract and nasopharynx. J Clin Pathol. 62:1085–1095. 2009.PubMed/NCBI View Article : Google Scholar
21	Lee TJ, Huang CC, Chen YW, Chang KP, Fu CH and Chang PH: Medially originated inverted papilloma. Otolaryngol Head Neck Surg. 140:324–329. 2009.PubMed/NCBI View Article : Google Scholar
22	Lawson W, Kaufman MR and Biller HF: Treatment outcomes in the management of inverted papilloma: An analysis of 160 cases. Laryngoscope. 113:1548–1556. 2003.PubMed/NCBI View Article : Google Scholar
23	Mirza S, Bradley PJ, Acharya A, Stacey M and Jones NS: Sinonasal inverted papillomas: Recurrence, and synchronous and metachronous malignancy. J Laryngol Otol. 121:857–864. 2007.PubMed/NCBI View Article : Google Scholar
24	Som MP and Curtin HD: Head and Neck Imaging. Vol 2. 5th edition. Mosby, St. Louis, MO, 2021.
25	Postolache P and Marciniuk D: Handbook of Pulmonary Rehabilitation. Nova Science Publishers, New York, NY, pp11-13, 2021.
26	Soare I: Insurance Medicine. Etna Publishing House, Bucharest, pp43-61, 2017.
27	Ash JE and Old JW: Hemangiomas of the nasal septum. Trans Am Acad Opthalmol Otolaryngol. 54:350–356. 1950.PubMed/NCBI
28	Willis RA and Collins WH: Pathology of tumors. Br J Surg. 35(446)1948.
29	Iwata N, Hattori K, Nakagawa T and Tsujimura T: Hemangioma of the nasal cavity: A clinicopathologic study. Auris Nasus Larynx. 29:335–339. 2002.PubMed/NCBI View Article : Google Scholar
30	Dillon WP, Som PM and Rosenau W: Hemangioma of the nasal vault: MR and CT features. Radiology. 180:761–765. 1991.PubMed/NCBI View Article : Google Scholar
31	Itoh K, Nishimura K, Togashi K, Fujisawa I, Nakano Y, Itoh H and Torizuka K: MR imaging of cavernous hemangioma of face and neck. J Comput Assist Tomogr. 10:831–835. 1986.PubMed/NCBI View Article : Google Scholar
32	Azzolini A, Bertani A and Riberti C: Superselective embolization and immediate surgical treatment: our present approach to treatment of large vascular hemangioma of the face. Ann Plastic Surg. 9:42–60. 1982.PubMed/NCBI View Article : Google Scholar
33	Howerd LL: Laser in endonasal surgery. Otolaryngol Clin North Am. 30:451–455. 1997.PubMed/NCBI
34	Jungheim M and Chilla R: The monthly interesting case-case no. 64. cavernous hemangioma. Laryngorhinootologie. 83:665–668. 2004.PubMed/NCBI View Article : Google Scholar : (In German).
35	Fink AM and Berkowitz RG: Sonography in preauricular pilomatrixoma of childhood. Ann Otol Rhinol Laryngol. 106:167–169. 1997.PubMed/NCBI View Article : Google Scholar
36	Graham JL and Merwin CF: The tent sign of pilomatricoma. Cutis. 22:577–580. 1978.PubMed/NCBI
37	Black SJ, Marble BF and Vuitch F: Multiple giant pilomatrix carcinomas of the head and neck. Otolaryngol Head Neck Surg. 109:543–547. 1993.PubMed/NCBI View Article : Google Scholar
38	Orlando RG, Rogers GL and Bremer DL: Pilomatricoma in a pediatric hospital. Arch Ophthalmol. 101:1209–1210. 1983.PubMed/NCBI View Article : Google Scholar
39	Urvoy M, Legall F, Toulemont PJ and Chevrant-Breton J: Multiple pilomatricoma. Apropos of a case. J Fr Ophthalmol. 19:464–466. 1996.PubMed/NCBI(In French).
40	Domanski HA and Domanski AM: Cytology of pilomatrixoma (calcifying epithelioma of Malherbe) in fine needle aspirates. Acta Cytol. 41:771–777. 1997.PubMed/NCBI View Article : Google Scholar
41	Morales A and McGoey J: Pilomatricoma: Treatment by incision and curettement. J Am Acad Dermatol. 2:44–46. 1980.PubMed/NCBI View Article : Google Scholar
42	Alecu I, Mocanu H and Călin IE: Intellectual mobility in higher education system. Rom J Mil Med CXX. 2:16–21. 2017.PubMed/NCBI View Article : Google Scholar
43	Kim WS, Hyun DW, Kim CH and Yoon JH: Treatment outcomes of sinonasal inverted papillomas according to surgical approaches. Acta Otolaryngol. 130:493–497. 2010.PubMed/NCBI View Article : Google Scholar
44	Osuch-Wójcikiewicz E, Wojas O, Nyckowska J, Checiński P, Sielska-Badurek E, Bruzgielewicz A, Szwedowicz P and Niemczyk K: Management of recurrent sinonasal inverted papilloma in the experience of ENT Department Medical University of Warsaw. Otolaryngol Pol. 64:73–76. 2010.PubMed/NCBI View Article : Google Scholar : (In Polish).
45	Lyngdoh NC, Ibohal TH and Marak IC: A study on the clinical profile and the management of inverted papilloma. Indian J Otolaryngol Head Neck Surg. 58:41–45. 2006.PubMed/NCBI View Article : Google Scholar
46	Benninger MS, Robert JK, Sibek BA, Levine HL, Tucker HM and Lavertu P: Inverted papilloma and associated squamous cell carcinoma. Otolaryngol Head Neck Surg. 103:457–461. 1990.
47	Neagos A, Cirticioiu A, Duca D and Csiszer I: Inverted papilloma of the nasal cavity-case report. Rom J Rhinol. 4:55–58. 2014.
48	Llorente JL, Deleyiannis F, Rodrigo JP, Nuñez F, Ablanedo P, Melón S and Suárez C: Minimally invasive treatment of the nasal inverted papilloma. Am J Rhinol. 17:335–341. 2003.PubMed/NCBI
49	Schlosser RJ, Mason JC and Gross CW: Aggressive endoscopic resection of inverted papilloma: An update. Otolaryngol Head Neck Surg. 125:49–53. 2001.PubMed/NCBI View Article : Google Scholar
50	Bielamowicz S, Calcaterra TC and Watson D: Inverting papilloma of the head and neck: The UCLA update. Otolaryngol Head Neck Surg. 109:71–76. 1993.PubMed/NCBI View Article : Google Scholar
51	Lund VJ: Optimum management of inverted papilloma. J Laryngol Otol. 114:194–197. 2000.PubMed/NCBI View Article : Google Scholar
52	Mohanty R, Dubey KP, Das SK and Chawla SC: Sinonasal inverted Schneiderian papilloma. Indian J Otolaryngol Head Neck Surg. 56:161–163. 2004.PubMed/NCBI View Article : Google Scholar
53	Eavey RD: Inverted papilloma of the nose and paranasal sinuses in childhood and adolescence. Laryngoscope. 95:17–23. 1985.PubMed/NCBI View Article : Google Scholar
54	Mitskavich MT, Carrau RL, Snyderman CH, Weissman JL and Fagan JJ: Intranasal endoscopic excision of a juvenile angiofibroma. Auris Nasus Larynx. 25:39–44. 1998.PubMed/NCBI View Article : Google Scholar
55	Kashima HK, Kessis T, Hruban RH, Wu TC, Zinreich SJ and Shah KV: Human papillomavirus in sinonasal papillomas and squamous cell carcinoma. Laryngoscope. 102:973–976. 1992.PubMed/NCBI View Article : Google Scholar
56	Furuta Y, Shinohara T, Sano K, Nagashima K, Inoue K, Tanaka K and Inuyama Y: Molecular pathologic study of the human papillomavirus infection in inverted papilloma and squamous cell carcinoma of the nasal cavities and paranasal sinuses. Laryngoscope. 101 (1 Pt 1):79–85. 1991.PubMed/NCBI View Article : Google Scholar