Serum levels of angiopoietin 2 mRNA in the mortality outcome prediction of septic shock

  • Authors:
    • Jun Feng
    • Lili Wang
    • Yikuan Feng
    • Gang Yu
    • Daixing Zhou
    • Junshuai Wang
  • View Affiliations

  • Published online on: April 1, 2022     https://doi.org/10.3892/etm.2022.11289
  • Article Number: 362
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Abstract

It has been reported that angiopoietin 2 (Ang‑2) plays an integral role in the pathophysiology of sepsis and many other inflammatory diseases. However, the specific role of Ang‑2 in septic shock has not been defined. The aim of the present study was to assess the predictive value of serum Ang‑2 in patients with septic shock. Clinical data of 85 patients with septic shock and 10 healthy controls admitted to the intensive care unit with a diagnosis of septic shock were collected between January 2020 and October 2020 at Tongji Hospital (Wuhan, China). The serum levels of Ang‑2 mRNA were quantified using a quantitative real‑time PCR assay. Ang‑2, SOFA and APACHE II scores were retrospectively analyzed in relation to 28‑day mortality. The area under the receiver operating characteristic (ROC) curve (AUC) was used to discriminate the accuracy of the prediction. Mean Ang‑2 mRNA levels in the patients with septic shock were significantly higher than those in the healthy controls (P<0.05), and the Ang‑2 levels showed a downwards trend over time following treatment. The three indicators (AUCs, SEMs, P‑values) were Ang‑2 (0.82, 0.03, P<0.01), SOFA score (0.76, 0.04, P<0.01), and APACHE II score (0.73, 0.04, P<0.01). The present study confirmed that Ang‑2 mRNA levels were significantly elevated in septic shock. The Ang‑2 mRNA level at ICU admission in a patient with septic shock could be a predictive biomarker for mortality.
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May-2022
Volume 23 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Feng J, Wang L, Feng Y, Yu G, Zhou D and Wang J: Serum levels of angiopoietin 2 mRNA in the mortality outcome prediction of septic shock. Exp Ther Med 23: 362, 2022
APA
Feng, J., Wang, L., Feng, Y., Yu, G., Zhou, D., & Wang, J. (2022). Serum levels of angiopoietin 2 mRNA in the mortality outcome prediction of septic shock. Experimental and Therapeutic Medicine, 23, 362. https://doi.org/10.3892/etm.2022.11289
MLA
Feng, J., Wang, L., Feng, Y., Yu, G., Zhou, D., Wang, J."Serum levels of angiopoietin 2 mRNA in the mortality outcome prediction of septic shock". Experimental and Therapeutic Medicine 23.5 (2022): 362.
Chicago
Feng, J., Wang, L., Feng, Y., Yu, G., Zhou, D., Wang, J."Serum levels of angiopoietin 2 mRNA in the mortality outcome prediction of septic shock". Experimental and Therapeutic Medicine 23, no. 5 (2022): 362. https://doi.org/10.3892/etm.2022.11289