Open Access

Research progress of signaling pathways of the natural substances intervene dyslipidemia (Review)

  • Authors:
    • Ningning Cao
    • Xiaoxuan Li
    • Wanjing Zhang
    • Qingguo Wang
    • Yujuan Liang
    • Fujun Zhou
    • Xuefeng Xiao
  • View Affiliations

  • Published online on: June 7, 2022     https://doi.org/10.3892/etm.2022.11421
  • Article Number: 494
  • Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Dyslipidemia is an umbrella term for a range of lipid metabolic disorders in the body. This condition has been widely reported to greatly increase the risk of cardiovascular diseases, threatening human health. In recent years, advances in molecular biology have deepened understanding of the dyslipidemia‑related signaling pathways and specific mechanisms underlying dyslipidemia. Signaling pathways possess the ability to transmit an extracellular signal to the inside of the cell, leading to specific biological effects. Lipid metabolism disorders and lipid levels in the blood are frequently affected by aberrant alterations in the dyslipidemia‑related signaling pathways. Therefore, further investigations into these pathways are required for the prevention and treatment of dyslipidemia. The present review summarizes the characteristics of six dyslipidemia‑associated signaling pathways: Peroxisome proliferator‑activated receptor, adenosine monophosphate‑activated protein kinase, farnesoid X receptor, forkhead box O, adipocytokine and cyclic adenosine monophosphate signaling pathways. In particular, specific focus was placed on previous experimental studies and reports on the intervention effects of natural substances (compounds from animals, plants, marine organisms and microorganisms) on dyslipidemia.
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August-2022
Volume 24 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Cao N, Li X, Zhang W, Wang Q, Liang Y, Zhou F and Xiao X: Research progress of signaling pathways of the natural substances intervene dyslipidemia (Review). Exp Ther Med 24: 494, 2022.
APA
Cao, N., Li, X., Zhang, W., Wang, Q., Liang, Y., Zhou, F., & Xiao, X. (2022). Research progress of signaling pathways of the natural substances intervene dyslipidemia (Review). Experimental and Therapeutic Medicine, 24, 494. https://doi.org/10.3892/etm.2022.11421
MLA
Cao, N., Li, X., Zhang, W., Wang, Q., Liang, Y., Zhou, F., Xiao, X."Research progress of signaling pathways of the natural substances intervene dyslipidemia (Review)". Experimental and Therapeutic Medicine 24.2 (2022): 494.
Chicago
Cao, N., Li, X., Zhang, W., Wang, Q., Liang, Y., Zhou, F., Xiao, X."Research progress of signaling pathways of the natural substances intervene dyslipidemia (Review)". Experimental and Therapeutic Medicine 24, no. 2 (2022): 494. https://doi.org/10.3892/etm.2022.11421