ALK‑positive locally advanced lung cancer in a patient who achieved long‑term complete response with crizotinib: A case report

  • Authors:
    • Levent Emi̇rzeoglu
    • Ozgur Olmez
  • View Affiliations

  • Published online on: September 2, 2022     https://doi.org/10.3892/etm.2022.11587
  • Article Number: 650
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Abstract

In the last two decades, the existence of key oncogenic alterations, such as activating mutations or chromosomal reorganization, has become crucial in the advanced stage non‑small cell lung cancer (NSCLC) treatment paradigm. Among these, anaplastic lymphoma kinase (ALK) gene rearrangement is reported in 3‑7% of NSCLC cases worldwide. In patients who respond to long‑term ALK therapy, treatment duration is uncertain. The present study reported a case of variant type 1 ALK‑rearranged stage 3B lung adenocarcinoma that maintained a complete response for >6 years under treatment with crizotinib. As first‑line treatment, crizotinib was administered twice daily (250 mg) and a complete response was confirmed after 3 months. After a complete response to crizotinib for 6 years, the treatment was stopped and the patient was followed up. Multiple brain metastases were detected during the third month of follow‑up.
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November-2022
Volume 24 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Emi̇rzeoglu L and Olmez O: ALK‑positive locally advanced lung cancer in a patient who achieved long‑term complete response with crizotinib: A case report. Exp Ther Med 24: 650, 2022.
APA
Emi̇rzeoglu, L., & Olmez, O. (2022). ALK‑positive locally advanced lung cancer in a patient who achieved long‑term complete response with crizotinib: A case report. Experimental and Therapeutic Medicine, 24, 650. https://doi.org/10.3892/etm.2022.11587
MLA
Emi̇rzeoglu, L., Olmez, O."ALK‑positive locally advanced lung cancer in a patient who achieved long‑term complete response with crizotinib: A case report". Experimental and Therapeutic Medicine 24.5 (2022): 650.
Chicago
Emi̇rzeoglu, L., Olmez, O."ALK‑positive locally advanced lung cancer in a patient who achieved long‑term complete response with crizotinib: A case report". Experimental and Therapeutic Medicine 24, no. 5 (2022): 650. https://doi.org/10.3892/etm.2022.11587