Open Access

Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review)

  • Authors:
    • Cunliang Guo
    • Yungang Chen
    • Yuhe Wang
    • Yanke Hao
  • View Affiliations

  • Published online on: December 1, 2022     https://doi.org/10.3892/etm.2022.11743
  • Article Number: 44
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Intervertebral disc degeneration (IDD) is the leading cause of lower back pain, which is one of the primary factors that lead to disability and pose a serious economic burden. The key pathological processes involved are extracellular matrix degradation, autophagy, apoptosis, and inflammation of nucleus pulposus cells. Non‑coding RNAs (ncRNAs), including microRNAs, long ncRNAs and circular RNAs, are key regulators of the aforementioned processes. ncRNAs are differentially expressed in tissues of the intervertebral disc between healthy individuals and patients and participate in the pathological progression of IDD via a complex pattern of gene regulation. However, the regulatory mechanisms of ncRNAs in IDD remain unclear. The present review summarizes the latest insights into the regulatory role of ncRNAs in IDD and sheds light on potentially novel therapeutic strategies for IDD that may be implemented in the future.
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January-2023
Volume 25 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Guo C, Chen Y, Wang Y and Hao Y: Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review). Exp Ther Med 25: 44, 2023.
APA
Guo, C., Chen, Y., Wang, Y., & Hao, Y. (2023). Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review). Experimental and Therapeutic Medicine, 25, 44. https://doi.org/10.3892/etm.2022.11743
MLA
Guo, C., Chen, Y., Wang, Y., Hao, Y."Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review)". Experimental and Therapeutic Medicine 25.1 (2023): 44.
Chicago
Guo, C., Chen, Y., Wang, Y., Hao, Y."Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review)". Experimental and Therapeutic Medicine 25, no. 1 (2023): 44. https://doi.org/10.3892/etm.2022.11743