Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review)
- Authors:
- Cunliang Guo
- Yungang Chen
- Yuhe Wang
- Yanke Hao
-
Affiliations: Department of Orthopedics, First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, P.R. China, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, P.R. China, Department of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, P.R. China - Published online on: December 1, 2022 https://doi.org/10.3892/etm.2022.11743
- Article Number: 44
-
Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Maher C, Underwood M and Buchbinder R: Non-specific low back pain. Lancet. 389:736–747. 2017.PubMed/NCBI View Article : Google Scholar | |
Gianola S, Castellini G, Andreano A, Corbetta D, Frigerio P, Pecoraro V, Redaelli V, Tettamanti A, Turolla A, Moja L and Valsecchi MG: Effectiveness of treatments for acute and sub-acute mechanical non-specific low back pain: Protocol for a systematic review and network meta-analysis. Syst Rev. 8(196)2019.PubMed/NCBI View Article : Google Scholar | |
Tessier S and Risbud MV: Understanding embryonic development for cell-based therapies of intervertebral disc degeneration: Toward an effort to treat disc degeneration subphenotypes. Dev Dyn. 250:302–317. 2021.PubMed/NCBI View Article : Google Scholar | |
Lyu FJ, Cui H, Pan H, Mc Cheung K, Cao X, Iatridis JC and Zheng Z: Painful intervertebral disc degeneration and inflammation: From laboratory evidence to clinical interventions. Bone Res. 9(7)2021.PubMed/NCBI View Article : Google Scholar | |
Ji ML, Jiang H, Zhang XJ, Shi PL, Li C, Wu H, Wu XT, Wang YT, Wang C and Lu J: Preclinical development of a microRNA-based therapy for intervertebral disc degeneration. Nat Commun. 9(5051)2018.PubMed/NCBI View Article : Google Scholar | |
Xu G, Liu C, Jiang J, Liang T, Yu C, Qin Z, Zhang Z, Lu Z and Zhan X: A novel mechanism of intervertebral disc degeneration: Imbalance between autophagy and apoptosis. Epigenomics. 12:1095–1108. 2020.PubMed/NCBI View Article : Google Scholar | |
Dong W, Liu J, Lv Y, Wang F, Liu T, Sun S, Liao B, Shu Z and Qian J: miR-640 aggravates intervertebral disc degeneration via NF-κB and WNT signalling pathway. Cell Prolif. 52(e12664)2019.PubMed/NCBI View Article : Google Scholar | |
Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, et al: Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 495:333–338. 2013.PubMed/NCBI View Article : Google Scholar | |
Mitra A, Pfeifer K and Park KS: Circular RNAs and competing endogenous RNA (ceRNA) networks. Transl Cancer Res. 7 (Suppl 5):S624–S628. 2018.PubMed/NCBI View Article : Google Scholar | |
Kabekkodu SP, Shukla V, Varghese VK, D'Souza J, Chakrabarty S and Satyamoorthy K: Clustered miRNAs and their role in biological functions and diseases. Biol Rev Camb Philos Soc. 93:1955–1986. 2018.PubMed/NCBI View Article : Google Scholar | |
Bridges MC, Daulagala AC and Kourtidis A: LNCcation: LncRNA localization and function. J Cell Biol. 220(e202009045)2021.PubMed/NCBI View Article : Google Scholar | |
Zheng S, Zhang X, Odame E, Xu X, Chen Y, Ye J, Zhou H, Dai D, Kyei B, Zhan S, et al: CircRNA-Protein interactions in muscle development and diseases. Int J Mol Sci. 22(3262)2021.PubMed/NCBI View Article : Google Scholar | |
Liu H, Huang X, Liu X, Xiao S, Zhang Y, Xiang T, Shen X, Wang G and Sheng B: miR-21 promotes human nucleus pulposus cell proliferation through PTEN/AKT signaling. Int J Mol Sci. 15:4007–4018. 2014.PubMed/NCBI View Article : Google Scholar | |
Xie L, Huang W, Fang Z, Ding F, Zou F, Ma X, Tao J, Guo J, Xia X, Wang H, et al: CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis. Cell Death Dis. 10(751)2019.PubMed/NCBI View Article : Google Scholar | |
Wang T, Li P, Ma X, Tian P, Han C, Zang J, Kong J and Yan H: MicroRNA-494 inhibition protects nucleus pulposus cells from TNF-α-induced apoptosis by targeting JunD. Biochimie. 115:1–7. 2015.PubMed/NCBI View Article : Google Scholar | |
Jing W and Jiang W: MicroRNA-93 regulates collagen loss by targeting MMP3 in human nucleus pulposus cells. Cell Prolif. 48:284–292. 2015.PubMed/NCBI View Article : Google Scholar | |
Gu SX, Li X, Hamilton JL, Chee A, Kc R, Chen D, An HS, Kim JS, Oh CD, Ma YZ, et al: MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc. Gene. 555:80–87. 2015.PubMed/NCBI View Article : Google Scholar | |
Lan PH, Liu ZH, Pei YJ, Wu ZG, Yu Y, Yang YF, Liu X, Che L, Ma CJ, Xie YK, et al: Landscape of RNAs in human lumbar disc degeneration. Oncotarget. 7:63166–63176. 2016.PubMed/NCBI View Article : Google Scholar | |
Liu X, Che L, Xie YK, Hu QJ, Ma CJ, Pei YJ, Wu ZG, Liu ZH, Fan LY and Wang HQ: Noncoding RNAs in human intervertebral disc degeneration: An integrated microarray study. Genom Data. 5:80–81. 2015.PubMed/NCBI View Article : Google Scholar | |
Xi Y, Jiang T, Wang W, Yu J, Wang Y, Wu X and He Y: Long non-coding HCG18 promotes intervertebral disc degeneration by sponging miR-146a-5p and regulating TRAF6 expression. Sci Rep. 7(13234)2017.PubMed/NCBI View Article : Google Scholar | |
Zhu J, Zhang X, Gao W, Hu H, Wang X and Hao D: lncRNA/circRNA-miRNA-mRNA ceRNA network in lumbar intervertebral disc degeneration. Mol Med Rep. 20:3160–3174. 2019.PubMed/NCBI View Article : Google Scholar | |
Fontana G, See E and Pandit A: Current trends in biologics delivery to restore intervertebral disc anabolism. Adv Drug Deliv Rev. 84:146–158. 2015.PubMed/NCBI View Article : Google Scholar | |
Xu D, Ma X, Sun C, Han J, Zhou C, Wong SH, Chan MTV and Wu WKK: Circular RNAs in intervertebral disc degeneration: An updated review. Front Mol Biosci. 8(781424)2022.PubMed/NCBI View Article : Google Scholar | |
Cazzanelli P and Wuertz-Kozak K: MicroRNAs in intervertebral disc degeneration, apoptosis, inflammation, and mechanobiology. Int J Mol Sci. 21(3601)2020.PubMed/NCBI View Article : Google Scholar | |
Dowdell J, Erwin M, Choma T, Vaccaro A, Iatridis J and Cho SK: Intervertebral disk degeneration and repair. Neurosurgery. 80 (3S):S46–S54. 2017.PubMed/NCBI View Article : Google Scholar | |
Li G, Ma L, He S, Luo R, Wang B, Zhang W, Song Y, Liao Z, Ke W, Xiang Q, et al: WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration. Nat Commun. 13(1469)2022.PubMed/NCBI View Article : Google Scholar | |
Zhou Y, Deng M, Su J, Zhang W, Liu D and Wang Z: The role of miR-31-5p in the development of intervertebral disc degeneration and its therapeutic potential. Front Cell Dev Biol. 9(633974)2021.PubMed/NCBI View Article : Google Scholar | |
Xie L, Chen Z, Liu M, Huang W, Zou F, Ma X, Tao J, Guo J, Xia X, Lyu F, et al: MSC-Derived exosomes protect vertebral endplate chondrocytes against apoptosis and calcification via the miR-31-5p/ATF6 Axis. Mol Ther Nucleic Acids. 22:601–614. 2020.PubMed/NCBI View Article : Google Scholar | |
Mi B, Li Q, Li T, Liu G and Sai J: High miR-31-5p expression promotes colon adenocarcinoma progression by targeting TNS1. Aging (Albany NY). 12:7480–7490. 2020.PubMed/NCBI View Article : Google Scholar | |
Li P, Cai JX, Han F, Wang J, Zhou JJ, Shen KW and Wang LH: Expression and significance of miR-654-5p and miR-376b-3p in patients with colon cancer. World J Gastrointest Oncol. 12:492–502. 2020.PubMed/NCBI View Article : Google Scholar | |
Lu M, Wang C, Chen W, Mao C and Wang J: miR-654-5p Targets GRAP to promote proliferation, metastasis, and chemoresistance of oral squamous cell carcinoma through Ras/MAPK signaling. DNA Cell Biol. 37:381–388. 2018.PubMed/NCBI View Article : Google Scholar | |
Wang S, Guo Y, Zhang X and Wang C: miR-654-5p inhibits autophagy by targeting ATG7 via mTOR signaling in intervertebral disc degeneration. Mol Med Rep. 23(444)2021.PubMed/NCBI View Article : Google Scholar | |
Du K, He X and Deng J: MicroRNA-16 inhibits the lipopolysaccharide-induced inflammatory response in nucleus pulposus cells of the intervertebral disc by targeting TAB3. Arch Med Sci. 17:500–513. 2018.PubMed/NCBI View Article : Google Scholar | |
He J, Xue R, Li S, Lv J, Zhang Y, Fan L, Teng Y and Wei H: Identification of the potential molecular targets for human intervertebral disc degeneration based on bioinformatic methods. Int J Mol Med. 36:1593–1600. 2015.PubMed/NCBI View Article : Google Scholar | |
Li N, Gao Q, Zhou W, Lv X, Yang X and Liu X: MicroRNA-129-5p affects immune privilege and apoptosis of nucleus pulposus cells via regulating FADD in intervertebral disc degeneration. Cell Cycle. 19:933–948. 2020.PubMed/NCBI View Article : Google Scholar | |
Yang W and Sun P: Downregulation of microRNA-129-5p increases the risk of intervertebral disc degeneration by promoting the apoptosis of nucleus pulposus cells via targeting BMP2. J Cell Biochem. 120:19684–19690. 2019.PubMed/NCBI View Article : Google Scholar | |
Zhou M, He SJ, Liu W, Yang MJ, Hou ZY, Meng Q and Qian ZL: EZH2 upregulates the expression of MAPK1 to promote intervertebral disc degeneration via suppression of miR-129-5p. J Gene Med. 24(e3395)2022.PubMed/NCBI View Article : Google Scholar | |
Cui S and Zhang L: microRNA-129-5p shuttled by mesenchymal stem cell-derived extracellular vesicles alleviates intervertebral disc degeneration via blockade of LRG1-mediated p38 MAPK activation. J Tissue Eng. 12(20417314211021679)2021.PubMed/NCBI View Article : Google Scholar | |
Tan L, Xie Y, Yuan Y and Hu K: LncRNA GAS5 as miR-26a-5p sponge regulates the PTEN/PI3K/Akt axis and affects extracellular matrix synthesis in degenerative nucleus pulposus cells in vitro. Front Neurol. 12(653341)2021.PubMed/NCBI View Article : Google Scholar | |
Jing W and Liu W: HOXC13-AS induced extracellular matrix loss via targeting miR-497-5p/ADAMTS5 in intervertebral disc. Front Mol Biosci. 8(643997)2021.PubMed/NCBI View Article : Google Scholar | |
Bao X, Ren T, Huang Y, Sun K, Wang S, Liu K, Zheng B and Guo W: Knockdown of long non-coding RNA HOTAIR increases miR-454-3p by targeting Stat3 and Atg12 to inhibit chondrosarcoma growth. Cell Death Dis. 8(e2605)2017.PubMed/NCBI View Article : Google Scholar | |
Li E, Zhao Z, Ma B and Zhang J: Long noncoding RNA HOTAIR promotes the proliferation and metastasis of osteosarcoma cells through the AKT/mTOR signaling pathway. Exp Ther Med. 14:5321–5328. 2017.PubMed/NCBI View Article : Google Scholar | |
Mercer TR, Dinger ME and Mattick JS: Long non-coding RNAs: Insights into functions. Nat Rev Genet. 10:155–159. 2009.PubMed/NCBI View Article : Google Scholar | |
Zhan S, Wang K, Xiang Q, Song Y, Li S, Liang H, Luo R, Wang B, Liao Z, Zhang Y and Yang C: lncRNA HOTAIR upregulates autophagy to promote apoptosis and senescence of nucleus pulposus cells. J Cell Physiol. 235:2195–2208. 2020.PubMed/NCBI View Article : Google Scholar | |
Zhan S, Wang K, Song Y, Li S, Yin H, Luo R, Liao Z, Wu X, Zhang Y and Yang C: Long non-coding RNA HOTAIR modulates intervertebral disc degenerative changes via Wnt/β-catenin pathway. Arthritis Res Ther. 21(201)2019.PubMed/NCBI View Article : Google Scholar | |
Zhu D, Yu Y, Wang W, Wu K, Liu D, Yang Y, Zhang C, Qi Y and Zhao S: Long noncoding RNA PART1 promotes progression of non-small cell lung cancer cells via JAK-STAT signaling pathway. Cancer Med. 8:6064–6081. 2019.PubMed/NCBI View Article : Google Scholar | |
Zhou T, Wu L, Ma N, Tang F, Zong Z and Chen S: LncRNA PART1 regulates colorectal cancer via targeting miR-150-5p/miR-520h/CTNNB1 and activating Wnt/β-catenin pathway. Int J Biochem Cell Biol. 118(105637)2020.PubMed/NCBI View Article : Google Scholar | |
Zhao B, Lu M, Wang D, Li H and He X: Genome-Wide identification of long noncoding RNAs in human intervertebral disc degeneration by RNA sequencing. Biomed Res Int. 2016(3684875)2016.PubMed/NCBI View Article : Google Scholar | |
Zhang Z, Huo Y, Zhou Z, Zhang P and Hu J: Role of lncRNA PART1 in intervertebral disc degeneration and associated underlying mechanism. Exp Ther Med. 21(131)2021.PubMed/NCBI View Article : Google Scholar | |
Xiang Q, Kang L, Wang J, Liao Z, Song Y, Zhao K, Wang K, Yang C and Zhang Y: CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis. EBioMedicine. 53(102679)2020.PubMed/NCBI View Article : Google Scholar | |
Chen Z, Zhang W, Deng M, Li Y and Zhou Y: CircGLCE alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of miR-587/STAP1. Aging (Albany NY). 12:21971–21991. 2020.PubMed/NCBI View Article : Google Scholar | |
Mizushima N and Komatsu M: Autophagy: Renovation of cells and tissues. Cell. 147:728–741. 2011.PubMed/NCBI View Article : Google Scholar | |
Kim KH and Lee MS: Autophagy-a key player in cellular and body metabolism. Nat Rev Endocrinol. 10:322–337. 2014.PubMed/NCBI View Article : Google Scholar | |
Kritschil R, Scott M, Sowa G and Vo N: Role of autophagy in intervertebral disc degeneration. J Cell Physiol. 237:1266–1284. 2022.PubMed/NCBI View Article : Google Scholar | |
Wang F, Cai F, Shi R, Wang XH and Wu XT: Aging and age related stresses: A senescence mechanism of intervertebral disc degeneration. Osteoarthritis Cartilage. 24:398–408. 2016.PubMed/NCBI View Article : Google Scholar | |
Li H, Tian L, Li J, Li Y, Du L, Huo Z and Xu B: The roles of circRNAs in intervertebral disc degeneration: Inflammation, extracellular matrix metabolism, and apoptosis. Anal Cell Pathol (Amst). 2022(9550499)2022.PubMed/NCBI View Article : Google Scholar | |
Wu T, Jia X, Zhu Z, Guo K, Wang Q, Gao Z, Li X, Huang Y and Wu D: Inhibition of miR-130b-3p restores autophagy and attenuates intervertebral disc degeneration through mediating ATG14 and PRKAA1. Apoptosis. 27:409–425. 2022.PubMed/NCBI View Article : Google Scholar | |
Yu X, Liu Q, Wang Y, Bao Y, Jiang Y, Li M, Li Z, Wang B, Yu L, Wang S, et al: Depleted Long Noncoding RNA GAS5 relieves intervertebral disc degeneration via microRNA-17-3p/Ang-2. Oxid Med Cell Longev. 2022(1792412)2022.PubMed/NCBI View Article : Google Scholar | |
Wen F, Yu J, He CJ, Zhang ZW and Yang AF: β-ecdysterone protects against apoptosis by promoting autophagy in nucleus pulposus cells and ameliorates disc degeneration. Mol Med Rep. 19:2440–2448. 2019.PubMed/NCBI View Article : Google Scholar | |
Yu X, Wang ZL, Han CL, Wang MW, Jin Y, Jin XB and Xia QH: LncRNA CASC15 functions as an oncogene by sponging miR-130b-3p in bladder cancer. Eur Rev Med Pharmacol Sci. 24(7203)2020.PubMed/NCBI View Article : Google Scholar | |
Liao Y, Wang C, Yang Z, Liu W, Yuan Y, Li K, Zhang Y, Wang Y, Shi Y, Qiu Y, et al: Dysregulated Sp1/miR-130b-3p/HOXA5 axis contributes to tumor angiogenesis and progression of hepatocellular carcinoma. Theranostics. 10:5209–5224. 2020.PubMed/NCBI View Article : Google Scholar | |
Guo Q, Zhu X, Wei R, Zhao L, Zhang Z, Yin X, Zhang Y, Chu C, Wang B and Li X: miR-130b-3p regulates M1 macrophage polarization via targeting IRF1. J Cell Physiol. 236:2008–2022. 2021.PubMed/NCBI View Article : Google Scholar | |
Li S, Geng J, Xu X, Huang X, Leng D, Jiang D, Liang J, Wang C, Jiang D and Dai H: miR-130b-3p modulates epithelial-mesenchymal crosstalk in lung fibrosis by targeting IGF-1. PLoS One. 11(e0150418)2016.PubMed/NCBI View Article : Google Scholar | |
Kalluri R and LeBleu VS: The biology, function, and biomedical applications of exosomes. Science. 367(eaau6977)2020.PubMed/NCBI View Article : Google Scholar | |
Luo L, Jian X, Sun H, Qin J, Wang Y, Zhang J, Shen Z, Yang D, Li C, Zhao P, et al: Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy. Stem Cells. 39:467–481. 2021.PubMed/NCBI View Article : Google Scholar | |
Chen D and Jiang X: Exosomes-derived miR-125-5p from cartilage endplate stem cells regulates autophagy and ECM metabolism in nucleus pulposus by targeting SUV38H1. Exp Cell Res. 414(113066)2022.PubMed/NCBI View Article : Google Scholar | |
Yao D, Zhou Z, Wang P, Zheng L, Huang Y, Duan Y, Liu B and Li Y: MiR-125-5p/IL-6R axis regulates macrophage inflammatory response and intestinal epithelial cell apoptosis in ulcerative colitis through JAK1/STAT3 and NF-κB pathway. Cell Cycle. 20:2547–2564. 2021.PubMed/NCBI View Article : Google Scholar | |
Sun L, Lian JX and Meng S: MiR-125a-5p promotes osteoclastogenesis by targeting TNFRSF1B. Cell Mol Biol Lett. 24(23)2019.PubMed/NCBI View Article : Google Scholar | |
Wang HQ, Yu XD, Liu ZH, Cheng X, Samartzis D, Jia LT, Wu SX, Huang J, Chen J and Luo ZJ: Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase-3. J Pathol. 225:232–242. 2011.PubMed/NCBI View Article : Google Scholar | |
Zhang WL, Chen YF, Meng HZ, Du JJ, Luan GN, Wang HQ, Yang MW and Luo ZJ: Role of miR-155 in the regulation of MMP-16 expression in intervertebral disc degeneration. J Orthop Res. 35:1323–1334. 2017.PubMed/NCBI View Article : Google Scholar | |
Zhou X, Li J, Teng J, Liu Y, Zhang D, Liu L and Zhang W: microRNA-155-3p attenuates intervertebral disc degeneration via inhibition of KDM3A and HIF1α. Inflamm Res. 70:297–308. 2021.PubMed/NCBI View Article : Google Scholar | |
Liu Z, Xu L, Zhang K, Guo B, Cui Z and Gao N: LINC00210 plays oncogenic roles in non-small cell lung cancer by sponging microRNA-328-5p. Exp Ther Med. 19:3325–3331. 2020.PubMed/NCBI View Article : Google Scholar | |
Yan J, Wu LG, Zhang M, Fang T, Pan W, Zhao JL and Zhou Q: miR-328-5p induces human intervertebral disc degeneration by targeting WWP2. Oxid Med Cell Longev. 2022(3511967)2022.PubMed/NCBI View Article : Google Scholar | |
Li Z, Li X, Chen C, Li S, Shen J, Tse G, Chan MTV and Wu WKK: Long non-coding RNAs in nucleus pulposus cell function and intervertebral disc degeneration. Cell Prolif. 51(e12483)2018.PubMed/NCBI View Article : Google Scholar | |
Mayama T, Marr AK and Kino T: Differential expression of glucocorticoid receptor noncoding RNA Repressor Gas5 in autoimmune and inflammatory diseases. Horm Metab Res. 48:550–557. 2016.PubMed/NCBI View Article : Google Scholar | |
Kolenda T, Guglas K, Kopczyńska M, Sobocińska J, Teresiak A, Bliźniak R and Lamperska K: Good or not good: Role of miR-18a in cancer biology. Rep Pract Oncol Radiother. 25:808–819. 2020.PubMed/NCBI View Article : Google Scholar | |
Klijn C, Durinck S, Stawiski EW, Haverty PM, Jiang Z, Liu H, Degenhardt J, Mayba O, Gnad F, Liu J, et al: A comprehensive transcriptional portrait of human cancer cell lines. Nat Biotechnol. 33:306–312. 2015.PubMed/NCBI View Article : Google Scholar | |
Xu L, Tan Y, Xu F and Zhang Y: Long noncoding RNA ADIRF antisense RNA 1 upregulates insulin receptor substrate 1 to decrease the aggressiveness of osteosarcoma by sponging microRNA-761. Bioengineered. 13:2028–2043. 2022.PubMed/NCBI View Article : Google Scholar | |
Zhong H, Zhou Z, Guo L, Liu FS, Wang X, Li J, Lv GH and Zou MX: SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis. Transl Res. 245:99–116. 2022.PubMed/NCBI View Article : Google Scholar | |
Zhao W, Geng D, Li S, Chen Z and Sun M: LncRNA HOTAIR influences cell growth, migration, invasion, and apoptosis via the miR-20a-5p/HMGA2 axis in breast cancer. Cancer Med. 7:842–855. 2018.PubMed/NCBI View Article : Google Scholar | |
Loewen G, Jayawickramarajah J, Zhuo Y and Shan B: Functions of lncRNA HOTAIR in lung cancer. J Hematol Oncol. 7(90)2014.PubMed/NCBI View Article : Google Scholar | |
Yang L, Peng X, Li Y, Zhang X, Ma Y, Wu C, Fan Q, Wei S, Li H and Liu J: Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma. Mol Cancer. 18(78)2019.PubMed/NCBI View Article : Google Scholar | |
Wang X, Liu W, Wang P and Li S: RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotes apoptosis and sensitivity to cisplatin in oral squamous cell carcinoma. J Oral Pathol Med. 47:930–937. 2018.PubMed/NCBI View Article : Google Scholar | |
Zhang S, Song S, Cui W, Liu X and Sun Z: Mechanism of long Noncoding RNA HOTAIR in nucleus pulposus cell autophagy and apoptosis in intervertebral disc degeneration. Evid Based Complement Alternat Med. 2022(8504601)2022.PubMed/NCBI View Article : Google Scholar | |
Wang H, Zhu Y, Cao L, Guo Z, Sun K, Qiu W and Fan H: circARL15 plays a critical role in intervertebral disc degeneration by modulating miR-431-5p/DISC1. Front Genet. 12(669598)2021.PubMed/NCBI View Article : Google Scholar | |
Wang R, Zhou X, Luo G, Zhang J, Yang M and Song C: CircRNA RERE Promotes the oxidative stress-induced apoptosis and autophagy of nucleus pulposus cells through the miR-299-5p/Galectin-3 Axis. J Healthc Eng. 2021(2771712)2021.PubMed/NCBI View Article : Google Scholar | |
Liu Y, Yang Y, Lin Y, Wei B, Hu X, Xu L, Zhang W and Lu J: N6 -methyladenosine-modified circRNA RERE modulates osteoarthritis by regulating β-catenin ubiquitination and degradation. Cell Prolif: Jun 22, 2022 (Epub ahead of print). | |
Wang L, Wang P, Su X and Zhao B: Circ_0001658 promotes the proliferation and metastasis of osteosarcoma cells via regulating miR-382-5p/YB-1 axis. Cell Biochem Funct. 38:77–86. 2020.PubMed/NCBI View Article : Google Scholar | |
Meng GD and Xu BS: Circular RNA hsa_circ_0001658 inhibits intervertebral disc degeneration development by regulating hsa-miR-181c-5p/FAS. Comput Math Methods Med. 2021(7853335)2021.PubMed/NCBI View Article : Google Scholar | |
Duan X, Yu X and Li Z: Circular RNA hsa_circ_0001658 regulates apoptosis and autophagy in gastric cancer through microRNA-182/Ras-related protein Rab-10 signaling axis. Bioengineered. 13:2387–2397. 2022.PubMed/NCBI View Article : Google Scholar | |
Cosamalón-Gan I, Cosamalón-Gan T, Mattos-Piaggio G, Villar-Suárez V, García-Cosamalón J and Vega-Álvarez JA: Inflammation in the intervertebral disc herniation. Neurocirugia (Astur: Engl Ed). 32:21–35. 2021.PubMed/NCBI View Article : Google Scholar | |
Le Maitre CL, Hoyland JA and Freemont AJ: Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile. Arthritis Res Ther. 9(R77)2007.PubMed/NCBI View Article : Google Scholar | |
Risbud MV and Shapiro IM: Role of cytokines in intervertebral disc degeneration: Pain and disc content. Nat Rev Rheumatol. 10:44–56. 2014.PubMed/NCBI View Article : Google Scholar | |
Zhang S, Song S, Zhuang Y, Hu J, Cui W, Wang X, Zhao Z, Liu X and Sun Z: Role of microRNA-15a-5p/Sox9/NF-κB axis in inflammatory factors and apoptosis of murine nucleus pulposus cells in intervertebral disc degeneration. Life Sci. 277(119408)2021.PubMed/NCBI View Article : Google Scholar | |
Dong L and Dong B: miR-489-3p overexpression inhibits lipopolysaccharide-induced nucleus pulposus cell apoptosis, inflammation and extracellular matrix degradation via targeting Toll-like receptor 4. Exp Ther Med. 22(1323)2021.PubMed/NCBI View Article : Google Scholar | |
Ji Z, Guo R, Ma Z and Li H: Arctigenin inhibits apoptosis, extracellular matrix degradation, and inflammation in human nucleus pulposus cells by up-regulating miR-483-3p. J Clin Lab Anal. 36(e24508)2022.PubMed/NCBI View Article : Google Scholar | |
Che Z, Xueqin J and Zhang Z: LncRNA OIP5-AS1 accelerates intervertebral disc degeneration by targeting miR-25-3p. Bioengineered. 12:11201–11212. 2021.PubMed/NCBI View Article : Google Scholar | |
Zhang C, Yang H, Li Y, Huo P and Ma P: LNCRNA OIP5-AS1 regulates oxidative low-density lipoprotein-mediated endothelial cell injury via miR-320a/LOX1 axis. Mol Cell Biochem. 467:15–25. 2020.PubMed/NCBI View Article : Google Scholar | |
Zheng D, Wang B, Zhu X, Hu J, Sun J, Xuan J and Ge Z: LncRNA OIP5-AS1 inhibits osteoblast differentiation of valve interstitial cells via miR-137/TWIST11 axis. Biochem Biophys Res Commun. 511:826–832. 2019.PubMed/NCBI View Article : Google Scholar | |
Zhi L, Zhao J, Zhao H, Qing Z, Liu H and Ma J: Downregulation of LncRNA OIP5-AS1 Induced by IL-1β aggravates osteoarthritis via regulating miR-29b-3p/PGRN. Cartilage. 13 (2_suppl):1345S–1355S. 2021.PubMed/NCBI View Article : Google Scholar | |
Chen Y, Ni H, Zhao Y, Chen K, Li M, Li C, Zhu X and Fu Q: Potential role of lncRNAs in contributing to pathogenesis of intervertebral disc degeneration based on microarray data. Med Sci Monit. 21:3449–3458. 2015.PubMed/NCBI View Article : Google Scholar | |
Li T, Peng Y, Chen Y, Huang X, Li X, Zhang Z and Du J: Long intergenic non-coding RNA-00917 regulates the proliferation, inflammation, and pyroptosis of nucleus pulposus cells via targeting miR-149-5p/NOD-like receptor protein 1 axis. Bioengineered. 13:6036–6047. 2022.PubMed/NCBI View Article : Google Scholar | |
Liao ZW, Fan ZW, Huang Y, Liang CY, Liu C, Huang S and Chen CW: Long non-coding RNA MT1DP interacts with miR-365 and induces apoptosis of nucleus pulposus cells by repressing NRF-2-induced anti-oxidation in lumbar disc herniation. Ann Transl Med. 9(151)2021.PubMed/NCBI View Article : Google Scholar | |
Huang JG, Tang X, Wang JJ, Liu J, Chen P and Sun Y: A circular RNA, circUSP36, accelerates endothelial cell dysfunction in atherosclerosis by adsorbing miR-637 to enhance WNT4 expression. Bioengineered. 12:6759–6770. 2021.PubMed/NCBI View Article : Google Scholar | |
Liu Y and Zhang Y: Hsa_circ_0134111 promotes osteoarthritis progression by regulating miR-224-5p/CCL1 interaction. Aging (Albany NY). 13:20383–20394. 2021.PubMed/NCBI View Article : Google Scholar | |
Yan P, Sun C, Luan L, Han J, Qu Y, Zhou C and Xu D: Hsa_circ_0134111 promotes intervertebral disc degeneration via sponging miR-578. Cell Death Discov. 8(55)2022.PubMed/NCBI View Article : Google Scholar | |
Li Y, Wu X, Li J, Du L, Wang X, Cao J, Li H, Huo Z, Li G, Pan D, et al: Circ_0004354 might compete with circ_0040039 to induce NPCs death and inflammatory response by targeting miR-345-3p-FAF1/TP73 axis in intervertebral disc degeneration. Oxid Med Cell Longev. 2022(2776440)2022.PubMed/NCBI View Article : Google Scholar | |
Xin J, Wang Y, Zheng Z, Wang S, Na S and Zhang S: Treatment of intervertebral disc degeneration. Orthop Surg. 14:1271–1280. 2022.PubMed/NCBI View Article : Google Scholar | |
Guo HY, Guo MK, Wan ZY, Song F and Wang HQ: Emerging evidence on noncoding-RNA regulatory machinery in intervertebral disc degeneration: A narrative review. Arthritis Res Ther. 22(270)2020.PubMed/NCBI View Article : Google Scholar | |
Fekrazad R, Naghdi N, Nokhbatolfoghahaei H and Bagheri H: The combination of laser therapy and metal nanoparticles in cancer treatment originated from epithelial tissues: A literature review. J Lasers Med Sci. 7:62–75. 2016.PubMed/NCBI View Article : Google Scholar | |
Zhao K, Li D, Shi C, Ma X, Rong G, Kang H, Wang X and Sun B: Biodegradable polymeric nanoparticles as the delivery carrier for drug. Curr Drug Deliv. 13:494–499. 2016.PubMed/NCBI View Article : Google Scholar |