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Esketamine for treatment‑resistant depression: A review of clinical evidence (Review)

  • Authors:
    • Octavian Vasiliu
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    Affiliations: Department of Psychiatry, ‘Dr. Carol Davila’ University Emergency Central Military Hospital, Bucharest 010816, Romania
    Copyright: © Vasiliu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 111
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    Published online on: January 25, 2023
       https://doi.org/10.3892/etm.2023.11810
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Abstract

Treatment‑resistant depression (TRD) is a challenge for psychiatrists, even after more than seven decades since the first antidepressants were used in clinical practice. Non‑monoaminergic‑based drugs with antidepressant properties have been developed, but to date, only esketamine and brexanolone have been approved for TRD and postpartum depression, respectively. A narrative review on the efficacy and safety of esketamine in the main categories of depressive disorders has been conducted through four electronic databases (Pubmed, Cochrane, EMBASE and Clarivate/Web of Science) The primary objective of the present review was to find evidence that may support the usefulness of esketamine for patients diagnosed with TRD as well as data about its potential adverse effects in the short and long term. A total of 14 papers were reviewed, and their results support the recommendation of esketamine for treatment of TRD as an add‑on to antidepressants, but more data is needed in order to assess its long‑term efficacy and safety. It must also be mentioned that there have been a few trials which did not report a significant effect on the severity of depressive symptoms with esketamine in TRD, therefore, caution is indicated for patients initiated on this adjuvant agent. There has been insufficient data to formulate specific guidelines about esketamine administration because evidence about favorable or negative prognostic factors of this treatment has been lacking, and the duration of its administration has not been unanimously accepted. Novel directions for research have been identified, especially in the case of patients with TRD and substance use disorders, geriatric or bipolar depression or in major depression with psychotic features.
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1 

Gastaldon C, Papola D, Ostuzzi G and Barbui C: Esketamine for treatment resistant depression: A trick of smoke and mirrors? Epidemiol Psychiatr Sci. 29(e79)2020.PubMed/NCBI View Article : Google Scholar

2 

Vasiliu O: Investigational drugs for the treatment of depression (Part 1): Monoaminergic, orexinergic, GABA-ergic, and anti-inflammatory agents. Front Pharmacol. 13(884143)2022.PubMed/NCBI View Article : Google Scholar

3 

Vasiliu O: Investigational drugs for the treatment of depression (Part 2): Glutamatergic, cholinergic, sestrin modulators, and other agents. Front Pharmacol. 13(884155)2022.PubMed/NCBI View Article : Google Scholar

4 

Cristea IA and Naudat F: US Food and Drug Administration approval of esketamine and brexanolone. Lancet Psychiatry. 6:975–977. 2019.PubMed/NCBI View Article : Google Scholar

5 

Vasiliu O: Effects of the selective serotonin reuptake inhibitors over coagulation in patients with depressive disorders-a systematic review and retrospective analysis. Rom J Mil Med CXXII. 2:7–11. 2019.

6 

Janssen-Cilag Intl. Spravato, Summary of Product Characteristics. 2019. Retrieved online at https://www.ema.europa.eu/en/documents/product-information/spravato-epar-product-information_en.pdf. Accessed 19 July 2022.

7 

Hashimoto K, Kakiuchi T, Ohba H, Nishiyama S and Tsukada H: Reduction of dopamine D2/3 receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: A PET study in conscious monkeys. Eur Arch Psychiatry Clin Neurosci. 267:173–176. 2017.PubMed/NCBI View Article : Google Scholar

8 

Salahudeen MS, Wright CM and Peterson GM: Esketamine: New hope for the treatment of treatment-resistant depression? A narrative review. Ther Adv Drug Saf. 11(2042098620937899)2020.PubMed/NCBI View Article : Google Scholar

9 

Tomasetti C, Montemitro C, Fiengo ALC, Santone C, Orsolini L, Valchera A, Carano A, Pompili M, Serafini G, Perna G, et al: Novel pathways in the treatment of major depression: Focus on the glutamatergic system. Curr Pharm Des. 25:381–387. 2019.PubMed/NCBI View Article : Google Scholar

10 

Shin C and Kim YK: Ketamine in major depressive disorder: Mechanisms and future perspectives. Psychiatry Investig. 17:182–192. 2020.PubMed/NCBI View Article : Google Scholar

11 

Homayoun H and Moghaddam B: NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons. J Neurosci. 27:11496–11500. 2007.PubMed/NCBI View Article : Google Scholar

12 

Zarate CA Jr, Singh JB, Quiroz JA, De Jesus G, Denicoff KK, Luckenbaugh DA, Manji HK and Charney DS: A double-blind, placebo-controlled study of memantine in the treatment of major depression. Am J Psychiatry. 163:153–155. 2006.PubMed/NCBI View Article : Google Scholar

13 

Zarate CA Jr, Mathews D, Ibrahim L, Chaves JF, Marquardt C, Ukoh I, Jolkovsky L, Brutsche NE, Smith MA and Luckenbaugh DA: A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression. Biol Psychiatry. 74:257–264. 2013.PubMed/NCBI View Article : Google Scholar

14 

De Berardis D, Tomasetti C, Pompili M, Serafini G, Vellante F, Fornaro M, Valchera A, Perna G, Volpe U, Martinotti G, et al: An update on glutamatergic system in suicidal depression and on the role of esketamine. Curr Top Med Chem. 20:554–584. 2020.PubMed/NCBI View Article : Google Scholar

15 

Singh JB, Fedgchin M, Daly E, Xi L, Melman C, De Bruecker G, Tadic A, Sienaert P, Wiegand F, Manji H, et al: Intravenous esketamine in adult treatment-resistant depression: A double-blind, double-randomization, placebo-controlled study. Biol Psychiatry. 80:424–431. 2016.PubMed/NCBI View Article : Google Scholar

16 

Pompili M: Intranasal esketamine and current suicidal ideation with intent in major depression disorder: Beat the clock, save a life, start a strategy. Front Psychiatry. 11(325)2020.PubMed/NCBI View Article : Google Scholar

17 

Daly EJ, Singh JB, Fedgchin M, Cooper K, Lim P, Shelton RC, Thase ME, Winokur A, Van Nueten L, Manji H and Drevets WC: Efficacy and safety of intranasal esketamine adjunctive to oral antidepressant therapy in treatment-resistant depression: A randomized clinical trial. JAMA Psychiatry. 75:139–148. 2018.PubMed/NCBI View Article : Google Scholar

18 

De Berardis D, Fornaro M, Valchera A, Cavuto M, Perna G, Di Nicola M, Serafini G, Carano A, Pompili M, Vellante F, et al: Eradicating suicide at its roots: Preclinical bases and clinical evidence of the efficacy of ketamine in the treatment of suicidal behaviors. Int J Mol Sci. 19(2888)2018.PubMed/NCBI View Article : Google Scholar

19 

Bernstein HG, Tausch A, Wagner R, Steiner J, Seeleke P, Walter M, Dobrowolny H and Bogerts B: Disruption of glutamate-glutamine-GABA cycle significantly impacts on suicidal behaviour: Survey of the literature and own findings on glutamine synthetase. CNS Neurol Disord Drug Targets. 12:900–913. 2013.PubMed/NCBI View Article : Google Scholar

20 

Tomasetti C, Iasevoli F, Buonaguro EF, De Berardis D, Fornaro M, Fiengo AL, Martinotti G, Orsolini L, Valchera A, Di Giannantonio M and de Bartolomeis A: Treating the synapse in major psychiatric disorders: The role of postsynaptic density network in dopamine-glutamate interplay and psychopharmacologic drugs molecular actions. Int J Mol Sci. 18(135)2017.PubMed/NCBI View Article : Google Scholar

21 

Schneidman ES: Suicide as psychache. J Nerv Ment Dis. 181:145–147. 1993.PubMed/NCBI View Article : Google Scholar

22 

Hashimoto K and Yang C: Is (S)-norketamine an alternative antidepressant for esketamine? Eur Arch Psychiatry Clin Neurosci. 269:867–868. 2019.PubMed/NCBI View Article : Google Scholar

23 

Fedgchin M, Trivedi M, Daly EJ, Melkote R, Lane R, Lim P, Vitagliano D, Blier P, Fava M, Liebowitz M, et al: Efficacy and safety of fixed-dose esketamine nasal spray combined with a new oral antidepressant in treatment-resistant depression: Results of a randomized, double-blind, active-controlled study (TRANSFORM-1). Int J Neuropsychopharmacol. 22:616–630. 2019.PubMed/NCBI View Article : Google Scholar

24 

Montgomery SA and Asberg M: A new depression scale designed to be sensitive to change. Br J Psychiatry. 134:382–389. 1979.PubMed/NCBI View Article : Google Scholar

25 

Popova V, Daly EJ, Trivedi M, Cooper K, Lane R, Lim P, Mazzucco C, Hough D, Thase ME, Shelton RC, et al: Efficacy and safety of flexibly dosed esketamine nasal spray combined with a newly initiated oral antidepressant in treatment-resistant depression: A randomized double-blind active-controlled study. Am J Psychiatry. 176:428–438. 2019.PubMed/NCBI View Article : Google Scholar

26 

Floden L, Hudgens S, Jamieson C, Popova V, Drevets WC, Cooper K and Singh J: Evaluation of individual items of the Patient Health Questionnaire (PHQ-9) and Montgomery-Asberg Depression Rating Scale (MADRS) in adults with treatment-resistant depression treated with esketamine nasal spray combined with a new oral antidepressant. CNS Drugs. 36:649–658. 2022.PubMed/NCBI View Article : Google Scholar

27 

Spitzer RL, Kroenke K and Williams JB: Validation and utility of a self-report version of PRIME-MD: The PHQ primary care study. Primary care evaluation of mental disorders. Patient health questionnaire. JAMA. 282:1737–1744. 1999.PubMed/NCBI View Article : Google Scholar

28 

Ochs-Ross R, Daly EJ, Zhang Y, Lane R, Lim P, Morrison RL, Hough D, Manji H, Drevets WC, Sanacora G, et al: Efficacy and safety of esketamine nasal spray plus an oral antidepressant in elderly patients with treatment-resistant depression-TRANSFORM 3. Am J Geriatr Psychiatry. 28:121–141. 2020.PubMed/NCBI View Article : Google Scholar

29 

Correia-Melo FS, Leal GC, Vieira F, Jesus-Nunes AP, Mello RP, Magnavita G, Caliman-Fontes AT, Echegaray MVF, Bandeira ID, Silva SS, et al: Efficacy and safety of adjunctive therapy using esketamine or racemic ketamine for adult treatment-resistant depression: A randomized, double-blind, non-inferiority study. J Affect Disord. 264:527–534. 2020.PubMed/NCBI View Article : Google Scholar

30 

Souza-Marques B, Telles M, Leal GC, Faria-Guimarães D, Correira-Melo FS, Jesus-Nunes AP, Vieira F, Souza L, Lins-Silva D, Mello RP, et al: Esketamine for unipolar major depression with psychotic features: A retrospective chart review and comparison with nonpsychotic depression. J Clin Psychopharmacol. 42:408–412. 2022.PubMed/NCBI View Article : Google Scholar

31 

Fu DJ, Ionescu DF, Li X, Lane R, Lim P, Sanacora G, Hough D, Manji H, Drevets WC and Canuso CM: Esketamine nasal spray for rapid reduction of major depressive disorder symptoms in patients who have active suicidal ideation with intent: Double-blind, randomized study (ASPIRE I). J Clin Psychiatry. 81(19m13191)2020.PubMed/NCBI View Article : Google Scholar

32 

Ionescu DF, Fu DJ, Qiu X, Lane R, Lim P, Kasper S, Hough D, Drevets WC, Manji H and Canuso CM: Esketamine nasal spray for rapid reduction of depressive symptoms in patients with major depressive disorder who have active suicide ideation with intent: Results of a phase 3, double-blind, randomized study (ASPIRE II). Int J Neuropsychopharmacol. 24:22–31. 2021.PubMed/NCBI View Article : Google Scholar

33 

Busner J and Targum SD: The clinical global impressions scale: Applying a research tool in clinical practice. Psychiatry (Edgmont). 4:28–37. 2007.PubMed/NCBI

34 

Caruso CM, Ionescu DF, Li X, Qiu X, Lane R, Turkoz I, Nash AI, Lopena TJ and Fu DJ: Esketamine nasal spray for the rapid reduction of depressive symptoms in major depressive disorder with acute suicidal ideation or behavior. J Clin Psychopharmacol. 41:516–524. 2021.PubMed/NCBI View Article : Google Scholar

35 

Lindenmayer JP, Czobor P, Alphs L, Nathan AM, Anand R, Islam Z and Chou JC: InterSePT Study Group. The InterSePT scale for suicidal thinking reliability and validity. Schizophr Res. 63:161–170. 2003.PubMed/NCBI View Article : Google Scholar

36 

Takahashi N, Yamada A, Shiraishi A, Shimizu H, Goto R and Tominaga Y: Esketamine as add-on therapy to oral antidepressant in Japanese patients with treatment-resistant depression: A phase 2b randomized clinical study. BMC Psychiatry. 21(526)2021.PubMed/NCBI View Article : Google Scholar

37 

Araújo-de-Freitas L, Santos-Lima C, Mendoça-Filho E, Vieira F, França RJAF, Magnavita G, Cardoso TL, Correia-Melo FS, Leal GC, Jesus-Nunes AP, et al: Neurocognitive aspects of ketamine and esketamine on subjects with treatment-resistant depression: A comparative, randomized and double-blind study. Psychiatry Res. 303(114058)2021.PubMed/NCBI View Article : Google Scholar

38 

Pfenninger EG, Durieux ME and Himmelseher S: Cognitive impairment after small-dose ketamine isomers in comparison to equianalgesic racemic ketamine in human volunteers. Anesthesiology. 96:357–366. 2002.PubMed/NCBI View Article : Google Scholar

39 

Dijkstra FM, van de Loo AJ, Abdulahad S, Bosma ER, Hartog M, Huls H, Kuijper DC, de Vries E, Solanki B, Singh J, et al: The effects of intranasal esketamine on on-road driving performance in patients with major depressive disorder or persistent depressive disorder. J Psychopharmacol. 36:614–625. 2022.PubMed/NCBI View Article : Google Scholar

40 

Daly EJ, Trivedi MH, Janik A, Li H, Zhang Y, Li X, Lane R, Lim P, Duca AR, Hough D, et al: Efficacy of esketamine nasal spray plus oral antidepressant treatment for relapse prevention in patients with treatment-resistant depression: A randomized clinical trial. JAMA Psychiatry. 76:893–903. 2019.PubMed/NCBI View Article : Google Scholar

41 

Wajs E, Aluisio L, Holder R, Daly EJ, Lane R, Lim R, George JE, Morrison RL, Sanacora G, Young AH, et al: Esketamine nasal spray plus oral antidepressant in patients with treatment-resistant depression: Assessment of long-term safety in phase 3, open-label study (SUSTAIN-2). J Clin Psychiatry. 81(19m12891)2020.PubMed/NCBI View Article : Google Scholar

42 

Citrome L, DiBernardo A and Singh J: Appraising esketamine nasal spray for the management of treatment-resistant depression in adults: Number needed to treat, number needed to harm, and likelihood to be helped or harmed. J Affect Disord. 271:228–238. 2020.PubMed/NCBI View Article : Google Scholar

43 

Pompili M: Critical appraisal of major depression with suicidal ideation. Ann Gen Psychiatry. 18(7)2019.PubMed/NCBI View Article : Google Scholar

44 

Swainson J, Thomas RK, Archer S, Chrenek C, MacKay MA, Baker G, Dursun S, Klassen LJ, Chokka P and Demas ML: Esketamine for treatment resistant depression. Expert Rev Neurother. 19:899–911. 2019.PubMed/NCBI View Article : Google Scholar

45 

Sapkota A, Khurshid H, Qureshi IA, Jahan N, Went TR, Sultan W and Alfonso M: Efficacy and safety of intranasal esketamine in treatment-resistant depression in adults: A systematic review. Cureus. 13(e17352)2021.PubMed/NCBI View Article : Google Scholar

46 

Papakostas GI, Salloum NC, Hock RS, Jha MK, Murrough JW, Mathew SJ, Iosifescu DV and Fava M: Efficacy of esketamine augmentation in major depressive disorder: A meta-analysis. J Clin Psychiatry. 81(19r12889)2020.PubMed/NCBI View Article : Google Scholar

47 

Jawad MY, Di Vincenzo JD, Ceban F, Jaberi S, Lui LMW, Gillissie ES, Alnafeesi Y, Rosenblat JD and McIntyre RS: The efficacy and safety of adjunctive intranasal esketamine treatment in major depressive disorder: A systematic review and meta-analysis. Expert Opin Drug Saf. 21:841–852. 2022.PubMed/NCBI View Article : Google Scholar

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Spandidos Publications style
Vasiliu O: Esketamine for treatment‑resistant depression: A review of clinical evidence (Review). Exp Ther Med 25: 111, 2023.
APA
Vasiliu, O. (2023). Esketamine for treatment‑resistant depression: A review of clinical evidence (Review). Experimental and Therapeutic Medicine, 25, 111. https://doi.org/10.3892/etm.2023.11810
MLA
Vasiliu, O."Esketamine for treatment‑resistant depression: A review of clinical evidence (Review)". Experimental and Therapeutic Medicine 25.3 (2023): 111.
Chicago
Vasiliu, O."Esketamine for treatment‑resistant depression: A review of clinical evidence (Review)". Experimental and Therapeutic Medicine 25, no. 3 (2023): 111. https://doi.org/10.3892/etm.2023.11810
Copy and paste a formatted citation
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Spandidos Publications style
Vasiliu O: Esketamine for treatment‑resistant depression: A review of clinical evidence (Review). Exp Ther Med 25: 111, 2023.
APA
Vasiliu, O. (2023). Esketamine for treatment‑resistant depression: A review of clinical evidence (Review). Experimental and Therapeutic Medicine, 25, 111. https://doi.org/10.3892/etm.2023.11810
MLA
Vasiliu, O."Esketamine for treatment‑resistant depression: A review of clinical evidence (Review)". Experimental and Therapeutic Medicine 25.3 (2023): 111.
Chicago
Vasiliu, O."Esketamine for treatment‑resistant depression: A review of clinical evidence (Review)". Experimental and Therapeutic Medicine 25, no. 3 (2023): 111. https://doi.org/10.3892/etm.2023.11810
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