IFITM3 rs12252 polymorphism and coronavirus disease 2019 severity: A meta‑analysis

  • Authors:
    • Kai Yu
    • Jingjing Wang
    • Haibin Li
    • Wenjun Wang
  • View Affiliations

  • Published online on: February 21, 2023     https://doi.org/10.3892/etm.2023.11857
  • Article Number: 158
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Abstract

Interferon‑induced transmembrane protein 3 (IFITM3) serves a critical role in the immune defense against viral infection, including that of severe acute respiratory syndrome coronavirus 2. To the best of our knowledge, the association between IFITM3 rs12252 polymorphism and coronavirus disease 2019 (COVID‑19) severity has not been determined. In the present study, a meta‑analysis of published case‑control studies assessing the association between the IFITM3 rs12252 polymorphism and COVID‑19 severity was performed. PubMed, EMBASE, China National Knowledge Infrastructure, Wanfang and preprint servers were searched up to March 30, 2022. A fixed‑effect model was used to calculate odds ratio (OR) and 95% confidence interval (95% CI). Analyses were conducted for additive, dominant and recessive genetic models. A total of five studies were identified, with 1,443 mild‑to‑moderate cases and 667 severe cases, including 121 deaths. Overall, the CC genotype of IFITM3 rs12252 was associated with increased risk of severe COVID‑19 (OR=1.97, 95% CI, 1.06‑3.69) and mortality (OR=4.61, 95% CI, 1.44‑14.75) compared with the CT/TT genotypes. Stratified analysis by ethnicity revealed that this association was strong in Chinese individuals (severity, OR=2.84, 95% CI, 1.34‑6.04; mortality, OR=7.91, 95% CI, 1.29‑48.44), but not notable in Caucasians (severity, OR=0.79, 95% CI, 0.23‑2.80; mortality, OR=2.16, 95% CI, 0.37‑12.55). A significant association with mortality was observed in Caucasians when comparing patients with the C allele of IFITM3 rs12252 and those without (CC/CT vs. TT: OR=1.73, 95% CI, 1.09‑2.75). The results suggested that the IFTM3‑rs12252 CC genotype is associated with severe COVID‑19 and mortality in Chinese individuals and the IFTM3‑rs12252 C allele may be associated with COVID‑19 mortality in Caucasians. Large‑scale studies are needed to confirm the association in different global populations.
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April-2023
Volume 25 Issue 4

Print ISSN: 1792-0981
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Spandidos Publications style
Yu K, Wang J, Li H and Wang W: <em>IFITM3</em> rs12252 polymorphism and coronavirus disease 2019 severity: A meta‑analysis. Exp Ther Med 25: 158, 2023.
APA
Yu, K., Wang, J., Li, H., & Wang, W. (2023). <em>IFITM3</em> rs12252 polymorphism and coronavirus disease 2019 severity: A meta‑analysis. Experimental and Therapeutic Medicine, 25, 158. https://doi.org/10.3892/etm.2023.11857
MLA
Yu, K., Wang, J., Li, H., Wang, W."<em>IFITM3</em> rs12252 polymorphism and coronavirus disease 2019 severity: A meta‑analysis". Experimental and Therapeutic Medicine 25.4 (2023): 158.
Chicago
Yu, K., Wang, J., Li, H., Wang, W."<em>IFITM3</em> rs12252 polymorphism and coronavirus disease 2019 severity: A meta‑analysis". Experimental and Therapeutic Medicine 25, no. 4 (2023): 158. https://doi.org/10.3892/etm.2023.11857