Open Access

BP‑1‑102 exerts antitumor effects on T‑cell acute lymphoblastic leukemia cells by suppressing the JAK2/STAT3/c‑Myc signaling pathway

  • Authors:
    • Can Ye
    • Xueqin Ruan
    • Yan Zhao
    • Hongkai Zhu
    • Canfei Wang
    • Zhao Cheng
    • Hongling Peng
  • View Affiliations

  • Published online on: March 15, 2023     https://doi.org/10.3892/etm.2023.11890
  • Article Number: 191
  • Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Drug resistance and relapse of T‑cell acute lymphoblastic leukemia (T‑ALL) remain significant concerns for physicians; hence, the development and screening of effective targeted drugs remain important. Considering that STAT3 is emerging as a potential therapeutic target for T‑ALL, T‑ALL cell lines (MOLT‑4 and CUTLL1) were treated with BP‑1‑102, a small‑molecule inhibitor that blocks STAT3 phosphorylation. Cell Counting Kit‑8 assay and colony formation assay results showed that BP‑1‑102 inhibited T‑ALL cell proliferation and colony formation. Flow cytometry and morphological results demonstrated that BP‑1‑102 dramatically induced apoptosis and caused cell cycle arrest at the G0/G1 phase in T‑ALL cell lines. Western blotting results indicated that BP‑1‑102 suppressed the JAK2/STAT3/c‑Myc pathway activity in T‑ALL cell lines. In conclusion, BP‑1‑102 suppressed the JAK2/STAT3/c‑Myc signaling pathway in T‑ALL cells and exerted various antitumor effects, representing a promising targeted antitumor inhibitor.
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May-2023
Volume 25 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ye C, Ruan X, Zhao Y, Zhu H, Wang C, Cheng Z and Peng H: BP‑1‑102 exerts antitumor effects on T‑cell acute lymphoblastic leukemia cells by suppressing the JAK2/STAT3/c‑Myc signaling pathway. Exp Ther Med 25: 191, 2023.
APA
Ye, C., Ruan, X., Zhao, Y., Zhu, H., Wang, C., Cheng, Z., & Peng, H. (2023). BP‑1‑102 exerts antitumor effects on T‑cell acute lymphoblastic leukemia cells by suppressing the JAK2/STAT3/c‑Myc signaling pathway. Experimental and Therapeutic Medicine, 25, 191. https://doi.org/10.3892/etm.2023.11890
MLA
Ye, C., Ruan, X., Zhao, Y., Zhu, H., Wang, C., Cheng, Z., Peng, H."BP‑1‑102 exerts antitumor effects on T‑cell acute lymphoblastic leukemia cells by suppressing the JAK2/STAT3/c‑Myc signaling pathway". Experimental and Therapeutic Medicine 25.5 (2023): 191.
Chicago
Ye, C., Ruan, X., Zhao, Y., Zhu, H., Wang, C., Cheng, Z., Peng, H."BP‑1‑102 exerts antitumor effects on T‑cell acute lymphoblastic leukemia cells by suppressing the JAK2/STAT3/c‑Myc signaling pathway". Experimental and Therapeutic Medicine 25, no. 5 (2023): 191. https://doi.org/10.3892/etm.2023.11890