Drug‑resistant Acinetobacter baumannii: From molecular mechanisms to potential therapeutics (Review)
- Authors:
- Hao-Jia Wu
- Zhi-Gang Xiao
- Xiao-Juan Lv
- Hai-Tang Huang
- Chu Liao
- Chen-Yang Hui
- Yue Xu
- Heng-Fei Li
-
Affiliations: Clinical College of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China, Department of Orthopedics, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430061, P.R. China, Department of Hepatology, Hubei Key Laboratory of The Theory and Application Research of Liver and Kidney in Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430061, P.R. China - Published online on: March 23, 2023 https://doi.org/10.3892/etm.2023.11908
- Article Number: 209
-
Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Mojica MF, Rossi MA, Vila AJ and Bonomo RA: The urgent need for metallo-β-lactamase inhibitors: An unattended global threat. Lancet Infect Dis. 22:e28–e34. 2022.PubMed/NCBI View Article : Google Scholar | |
Khan SN and Khan AU: Breaking the spell: Combating multidrug resistant ‘superbugs.’. Front Microbiol. 7(174)2016.PubMed/NCBI View Article : Google Scholar | |
Boral B, Unaldi Ö, Ergin A, Durmaz R and Eser ÖK: Acinetobacter Study Group. A prospective multicenter study on the evaluation of antimicrobial resistance and molecular epidemiology of multidrug-resistant Acinetobacter baumanni infections in intensive care units with clinical and environmental features. Ann Clin Microbiol Antimicrob. 18(19)2019.PubMed/NCBI View Article : Google Scholar | |
Torres HA, Vázquez EG, Yagüe G and Gómez JG: Multidrug resistant Acinetobacter baumanii: Clinical update and new highlights. Rev Esp Quimioter. 23:12–19. 2010.PubMed/NCBI(In Spanish). | |
Vázquez-López R, Solano-Gálvez SG, Juárez Vignon-Whaley JJ, Abello Vaamonde JA, Padró Alonzo LA, Rivera Reséndiz A, Muleiro Álvarez M, Vega López EN, Franyuti-Kelly G, Álvarez-Hernández DA, et al: Acinetobacter baumannii resistance: A real challenge for clinicians. Antibiotics (Basel). 9(205)2020.PubMed/NCBI View Article : Google Scholar | |
Ayoub Moubareck C and Hammoudi Halat D: Insights into Acinetobacter baumannii: A review of microbiological, virulence, and resistance traits in a threatening nosocomial pathogen. Antibiotics (Basel). 9(119)2020.PubMed/NCBI View Article : Google Scholar | |
Ibrahim S, Al-Saryi N, Al-Kadmy IMS and Aziz SN: Multidrug-resistant Acinetobacter baumannii as an emerging concern in hospitals. Mol Biol Rep. 48:6987–6998. 2021.PubMed/NCBI View Article : Google Scholar | |
Harding CM, Hennon SW and Feldman MF: Uncovering the mechanisms of Acinetobacter baumannii virulence. Nat Rev Microbiol. 16:91–102. 2018.PubMed/NCBI View Article : Google Scholar | |
Bagińska N, Pichlak A, Górski A and Jończyk-Matysiak E: Specific and selective bacteriophages in the fight against multidrug-resistant Acinetobacter baumannii. Virol Sin. 34:347–357. 2019.PubMed/NCBI View Article : Google Scholar | |
Roy S, Chowdhury G, Mukhopadhyay AK, Dutta S and Basu S: Convergence of biofilm formation and antibiotic resistance in Acinetobacter baumannii infection. Front Med (Lausanne). 9(793615)2022.PubMed/NCBI View Article : Google Scholar | |
Ma C and McClean S: Mapping global prevalence of Acinetobacter baumannii and recent vaccine development to tackle it. Vaccines (Basel). 9(570)2021.PubMed/NCBI View Article : Google Scholar | |
Colquhoun JM and Rather PN: Insights into mechanisms of biofilm formation in Acinetobacter baumannii and implications for uropathogenesis. Front Cell Infect Microbiol. 10(253)2020.PubMed/NCBI View Article : Google Scholar | |
Bergogne-Bérézin E and Towner KJ: Acinetobacter spp. as nosocomial pathogens: Microbiological, clinical, and epidemiological features. Clin Microbiol Rev. 9:148–165. 1996.PubMed/NCBI View Article : Google Scholar | |
Ramirez MS, Bonomo RA and Tolmasky ME: Carbapenemases: Transforming Acinetobacter baumannii into a yet more dangerous menace. Biomolecules. 10(720)2020.PubMed/NCBI View Article : Google Scholar | |
Chapartegui-González I, Lázaro-Díez M, Bravo Z, Navas J, Icardo JM and Ramos-Vivas J: Acinetobacter baumannii maintains its virulence after long-time starvation. PLoS One. 13(e0201961)2018.PubMed/NCBI View Article : Google Scholar | |
Nguyen M and Joshi SG: Carbapenem resistance in Acinetobacter baumannii, and their importance in hospital-acquired infections: a scientific review. J Appl Microbiol. 131:2715–2738. 2021.PubMed/NCBI View Article : Google Scholar | |
Kim YA, Kim JJ, Won DJ and Lee K: Seasonal and temperature-associated increase in community-onset Acinetobacter baumannii complex colonization or infection. Ann Lab Med. 38:266–270. 2018.PubMed/NCBI View Article : Google Scholar | |
Guo J and Li C: Molecular epidemiology and decreased susceptibility to disinfectants in carbapenem-resistant Acinetobacter baumannii isolated from intensive care unit patients in central China. J Infect Public Health. 12:890–896. 2019.PubMed/NCBI View Article : Google Scholar | |
Weinberg SE, Villedieu A, Bagdasarian N, Karah N, Teare L and Elamin WF: Control and management of multidrug resistant Acinetobacter baumannii: A review of the evidence and proposal of novel approaches. Infect Prev Pract. 2(100077)2020.PubMed/NCBI View Article : Google Scholar | |
Oh DH, Kim YC, Kim EJ, Jung IY, Jeong SJ, Kim SY, Park MS, Kim A, Lee JG and Paik HC: Multidrug-resistant Acinetobacter baumannii infection in lung transplant recipients: Risk factors and prognosis. Infect Dis (Lond). 51:493–501. 2019.PubMed/NCBI View Article : Google Scholar | |
Martín-Aspas A, Guerrero-Sánchez FM, García-Colchero F, Rodríguez-Roca S and Girón-González JA: Differential characteristics of Acinetobacter baumannii colonization and infection: Risk factors, clinical picture, and mortality. Infect Drug Resist. 11:861–872. 2018.PubMed/NCBI View Article : Google Scholar | |
Nie D, Hu Y, Chen Z, Li M, Hou Z, Luo X, Mao X and Xue X: Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection. J Biomed Sci. 27(26)2020.PubMed/NCBI View Article : Google Scholar | |
Kyriakidis I, Vasileiou E, Pana ZD and Tragiannidis A: Acinetobacter baumannii antibiotic resistance mechanisms. Pathogens. 10(373)2021.PubMed/NCBI View Article : Google Scholar | |
Sawa T, Kooguchi K and Moriyama K: Molecular diversity of extended-spectrum β-lactamases and carbapenemases, and antimicrobial resistance. J Intensive Care. 8(13)2020.PubMed/NCBI View Article : Google Scholar | |
Tsivkovski R, Totrov M and Lomovskaya O: Biochemical characterization of QPX7728, a new ultrabroad-spectrum beta-lactamase inhibitor of serine and metallo-beta-lactamases. Antimicrob Agents Chemother. 64:e00130–20. 2020.PubMed/NCBI View Article : Google Scholar | |
Philippon A, Jacquier H, Ruppé E and Labia R: Structure-based classification of class A beta-lactamases, an update. Curr Res Transl Med. 67:115–122. 2019.PubMed/NCBI View Article : Google Scholar | |
Tooke CL, Hinchliffe P, Bragginton EC, Colenso CK, Hirvonen VHA, Takebayashi Y and Spencer J: β-Lactamases and β-lactamase inhibitors in the 21st century. J Mol Biol. 431:3472–3500. 2019.PubMed/NCBI View Article : Google Scholar | |
Palzkill T: Structural and mechanistic basis for extended-spectrum drug-resistance mutations in altering the specificity of TEM, CTX-M, and KPC β-lactamases. Front Mol Biosci. 5(16)2018.PubMed/NCBI View Article : Google Scholar | |
Nikibakhsh M, Firoozeh F, Badmasti F, Kabir K and Zibaei M: Molecular study of metallo-β-lactamases and integrons in Acinetobacter baumannii isolates from burn patients. BMC Infect Dis. 21(782)2021.PubMed/NCBI View Article : Google Scholar | |
Amin M, Navidifar T, Saleh Shooshtari F and Goodarzi H: Association of the genes encoding metallo-β-lactamase with the presence of integrons among multidrug-resistant clinical isolates of Acinetobacter baumannii. Infect Drug Resist. 12:1171–1180. 2019.PubMed/NCBI View Article : Google Scholar | |
López C, Ayala JA, Bonomo RA, González LJ and Vila AJ: Protein determinants of dissemination and host specificity of metallo-β-lactamases. Nat Commun. 10(3617)2019.PubMed/NCBI View Article : Google Scholar | |
Ejaz H, Alzahrani B, Hamad MFS, Abosalif KOA, Junaid K, Abdalla AE, Elamir MYM, Aljaber NJ, Hamam SSM and Younas S: Molecular analysis of the antibiotic resistant NDM-1 gene in clinical isolates of enterobacteriaceae. Clin Lab. 66:2020.PubMed/NCBI View Article : Google Scholar | |
Wu W, Feng Y, Tang G, Qiao F, McNally A and Zong Z: NDM metallo-β-lactamases and their bacterial producers in health care settings. Clin Microbiol Rev. 32:e00115–18. 2019.PubMed/NCBI View Article : Google Scholar | |
Junaid K: Molecular diversity of NDM-1, NDM-5, NDM-6, and NDM-7 variants of new delhi metallo-β-lactamases and their impact on drug resistance. Clin Lab. 67:2021.PubMed/NCBI View Article : Google Scholar | |
Jiang L, Yu Y, Zeng W, Guo J, Lv F, Wang X, Liu X and Zhao Z: Whole-genome analysis of New Delhi metallo-beta-lactamase-1-producing Acinetobacter haemolyticus from China. J Glob Antimicrob Resist. 20:204–208. 2020.PubMed/NCBI View Article : Google Scholar | |
Ingti B, Upadhyay S, Hazarika M, Khyriem AB, Paul D, Bhattacharya P, Joshi SR, Bora D, Dhar D and Bhattacharjee A: Distribution of carbapenem resistant Acinetobacter baumannii with blaADC-30 and induction of ADC-30 in response to beta-lactam antibiotics. Res Microbiol. 171:128–133. 2020.PubMed/NCBI View Article : Google Scholar | |
Said HS, Benmahmod AB and Ibrahim RH: Co-production of AmpC and extended spectrum beta-lactamases in cephalosporin-resistant Acinetobacter baumannii in Egypt. World J Microbiol Biotechnol. 34(189)2018.PubMed/NCBI View Article : Google Scholar | |
Bouza AA, Swanson HC, Smolen KA, VanDine AL, Taracila MA, Romagnoli C, Caselli E, Prati F, Bonomo RA, Powers RA and Wallar BJ: Structure-based analysis of boronic acids as inhibitors of acinetobacter-derived cephalosporinase-7, a unique class C β-lactamase. ACS Infect Dis. 4:325–336. 2018.PubMed/NCBI View Article : Google Scholar | |
Porbaran M, Tahmasebi H and Arabestani M: A comprehensive study of the relationship between the production of β-lactamase enzymes and iron/siderophore uptake regulatory genes in clinical isolates of Acinetobacter baumannii. Int J Microbiol. 2021(5565537)2021.PubMed/NCBI View Article : Google Scholar | |
Monem S, Furmanek-Blaszk B, Łupkowska A, Kuczyńska-Wiśnik D, Stojowska-Swędrzyńska K and Laskowska E: Mechanisms protecting Acinetobacter baumannii against multiple stresses triggered by the host immune response, antibiotics and outside-host environment. Int J Mol Sci. 21(5498)2020.PubMed/NCBI View Article : Google Scholar | |
Lupo A, Haenni M and Madec JY: Antimicrobial Resistance in Acinetobacter spp. and Pseudomonas spp. Microbiol Spectr. 16:2018.PubMed/NCBI View Article : Google Scholar | |
Hamidian M and Nigro SJ: Emergence, molecular mechanisms and global spread of carbapenem-resistant Acinetobacter baumannii. Microb Genom. 5(e000306)2019.PubMed/NCBI View Article : Google Scholar | |
Shi X, Wang H, Wang X, Jing H, Duan R, Qin S, Lv D, Fan Y, Huang Z, Stirling K, et al: Molecular characterization and antibiotic resistance of Acinetobacter baumannii in cerebrospinal fluid and blood. PLoS One. 16(e0247418)2021.PubMed/NCBI View Article : Google Scholar | |
Ibrahim ME: Prevalence of Acinetobacter baumannii in Saudi Arabia: Risk factors, antimicrobial resistance patterns and mechanisms of carbapenem resistance. Ann Clin Microbiol Antimicrob. 18(1)2019.PubMed/NCBI View Article : Google Scholar | |
Slusky JSG and Dunbrack RL Jr: Charge asymmetry in the proteins of the outer membrane. Bioinformatics. 29:2122–2128. 2013.PubMed/NCBI View Article : Google Scholar | |
Uppalapati SR, Sett A and Pathania R: The outer membrane proteins OmpA, CarO, and OprD of Acinetobacter baumannii confer a two-pronged defense in facilitating its success as a potent human pathogen. Front Microbiol. 11(589234)2020.PubMed/NCBI View Article : Google Scholar | |
Tsai YK, Liou CH, Lin JC, Fung CP, Chang FY and Siu LK: Effects of different resistance mechanisms on antimicrobial resistance in Acinetobacter baumannii: A strategic system for screening and activity testing of new antibiotics. Int J Antimicrob Agents. 55(105918)2020.PubMed/NCBI View Article : Google Scholar | |
Skerniškytė J, Karazijaitė E, Lučiūnaitė A and Sužiedėlienė E: OmpA protein-deficient Acinetobacter baumannii outer membrane vesicles trigger reduced inflammatory response. Pathogens. 10(407)2021.PubMed/NCBI View Article : Google Scholar | |
Zhang Y, Fan B, Luo Y, Tao Z, Nie Y, Wang Y, Ding F, Li Y and Gu D: Comparative analysis of carbapenemases, RND family efflux pumps and biofilm formation potential among Acinetobacter baumannii strains with different carbapenem susceptibility. BMC Infect Dis. 21(841)2021.PubMed/NCBI View Article : Google Scholar | |
Kim CM, Park G, Ko YJ, Kang SH and Jang SJ: Relationships between relative expression of RND efflux pump genes, H33342 efflux activity, biofilm-forming activity, and antimicrobial resistance in Acinetobacter baumannii clinical isolates. Jpn J Infect Dis. 74:499–506. 2021.PubMed/NCBI View Article : Google Scholar | |
Badmasti F, Habibi M, Firoozeh F, Fereshteh S, Bolourchi N and Goodarzi NN: The combination of CipA and PBP-7/8 proteins contribute to the survival of C57BL/6 mice from sepsis of Acinetobacter baumannii. Microb Pathog. 158(105063)2021.PubMed/NCBI View Article : Google Scholar | |
Liu H, Cao CY, Qiu FL, Huang HN, Xie H, Dong R, Shi YZ and Hu XN: Iron-rich conditions induce OmpA and virulence changes of Acinetobacter baumannii. Front Microbiol. 12(725194)2021.PubMed/NCBI View Article : Google Scholar | |
Abdul-Mutakabbir JC, Alosaimy S, Morrisette T, Kebriaei R and Rybak MJ: Cefiderocol: A novel siderophore cephalosporin against multidrug-resistant gram-negative pathogens. Pharmacotherapy. 40:1228–1247. 2020.PubMed/NCBI View Article : Google Scholar | |
Zhanel GG, Golden AR, Zelenitsky S, Wiebe K, Lawrence CK, Adam HJ, Idowu T, Domalaon R, Schweizer F, Zhanel MA, et al: Cefiderocol: A siderophore cephalosporin with activity against carbapenem-resistant and multidrug-resistant gram-negative bacilli. Drugs. 79:271–289. 2019.PubMed/NCBI View Article : Google Scholar | |
Isler B, Doi Y, Bonomo RA and Paterson DL: New treatment options against carbapenem-resistant Acinetobacter baumannii infections. Antimicrob Agents Chemother. 63:e01110–18. 2018.PubMed/NCBI View Article : Google Scholar | |
Sanchez-Carbonel A, Mondragón B, López-Chegne N, Peña-Tuesta I, Huayan-Dávila G, Blitchtein D, Carrillo-Ng H, Silva-Caso W, Aguilar-Luis MA and Del Valle-Mendoza J: The effect of the efflux pump inhibitor carbonyl cyanide m-chlorophenylhydrazone (CCCP) on the susceptibility to imipenem and cefepime in clinical strains of Acinetobacter baumannii. PLoS One. 16(e0259915)2021.PubMed/NCBI View Article : Google Scholar | |
Pal A and Tripathi A: Quercetin potentiates meropenem activity among pathogenic carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter baumannii. J Appl Microbiol. 127:1038–1047. 2019.PubMed/NCBI View Article : Google Scholar | |
Gellings PS, Wilkins AA and Morici LA: Recent advances in the pursuit of an effective Acinetobacter baumannii vaccine. Pathogens. 9(1066)2020.PubMed/NCBI View Article : Google Scholar | |
Pasteran F, Cedano J, Baez M, Albornoz E, Rapoport M, Osteria J, Montaña S, Le C, Ra G, Bonomo RA, et al: A new twist: The combination of sulbactam/avibactam enhances sulbactam activity against carbapenem-resistant Acinetobacter baumannii (CRAB) isolates. Antibiotics (Basel). 10(577)2021.PubMed/NCBI View Article : Google Scholar | |
Yahav D, Giske CG, Grāmatniece A, Abodakpi H, Tam VH and Leibovici L: New β-lactam-β-lactamase inhibitor combinations. Clin Microbiol Rev. 34:e00115–20. 2020.PubMed/NCBI View Article : Google Scholar | |
Bartal C, Rolston KVI and Nesher L: Carbapenem-resistant Acinetobacter baumannii: Colonization, infection and current treatment options. Infect Dis Ther. 11:683–694. 2022.PubMed/NCBI View Article : Google Scholar | |
Tamehri M, Rasooli I, Pishgahi M, Jahangiri A, Ramezanalizadeh F and Banisaeed Langroodi SR: Combination of BauA and OmpA elicit immunoprotection against Acinetobacter baumannii in a murine sepsis model. Microb Pathog. 173(105874)2022.PubMed/NCBI View Article : Google Scholar | |
Li X, Song Y, Wang L, Kang G, Wang P, Yin H and Huang H: A potential combination therapy of berberine hydrochloride with antibiotics against multidrug-resistant Acinetobacter baumannii. Front Cell Infect Microbiol. 11(660431)2021.PubMed/NCBI View Article : Google Scholar | |
Duarte A, Ferreira S, Silva F and Domingues FC: Synergistic activity of coriander oil and conventional antibiotics against Acinetobacter baumannii. Phytomedicine. 19:236–238. 2012.PubMed/NCBI View Article : Google Scholar | |
Herman A and Herman AP: Herbal products and their active constituents used alone and in combination with antibiotics against multidrug-resistant bacteria. Planta Med. 89:168–182. 2023.PubMed/NCBI View Article : Google Scholar | |
Lima WG, Alves MC, Cruz WS and Paiva MC: Chromosomally encoded and plasmid-mediated polymyxins resistance in Acinetobacter baumannii: A huge public health threat. Eur J Clin Microbiol Infect Dis. 37:1009–1019. 2018.PubMed/NCBI View Article : Google Scholar | |
Nasr P: Genetics, epidemiology, and clinical manifestations of multidrug-resistant Acinetobacter baumannii. J Hosp Infect. 104:4–11. 2020.PubMed/NCBI View Article : Google Scholar | |
Trebosc V, Gartenmann S, Tötzl M, Lucchini V, Schellhorn B, Pieren M, Lociuro S, Gitzinger M, Tigges M, Bumann D and Kemmer C: Dissecting colistin resistance mechanisms in extensively drug-resistant Acinetobacter baumannii clinical isolates. mBio. 10:e01083–19. 2019.PubMed/NCBI View Article : Google Scholar | |
Nurtop E, Bayındır Bilman F, Menekse S, Kurt Azap O, Gönen M, Ergonul O and Can F: Promoters of Colistin Resistance in Acinetobacter baumannii Infections. Microb Drug Resist. 25:997–1002. 2019.PubMed/NCBI View Article : Google Scholar | |
Wang Y, Luo Q, Xiao T, Zhu Y and Xiao Y: Impact of polymyxin resistance on virulence and fitness among clinically important gram-negative bacteria. Engineering. 13:178–185. 2022. | |
Moffatt JH, Harper M and Boyce JD: Mechanisms of polymyxin resistance. Adv Exp Med Biol. 1145:55–71. 2019.PubMed/NCBI View Article : Google Scholar | |
Nang SC, Azad MAK, Velkov T, Zhou Q and Li J: Rescuing the last-line polymyxins: Achievements and challenges. Pharmacol Rev. 73:679–728. 2021.PubMed/NCBI View Article : Google Scholar | |
Mohapatra SS, Dwibedy SK and Padhy I: Polymyxins, the last-resort antibiotics: Mode of action, resistance emergence, and potential solutions. J Biosci. 46(85)2021.PubMed/NCBI View Article : Google Scholar | |
Khaled JM, Alharbi NS, Siddiqi MZ, Alobaidi AS, Nauman K, Alahmedi S, Almazyed AO, Almosallam MA and Al Jurayyan AN: A synergic action of colistin, imipenem, and silver nanoparticles against pandrug-resistant Acinetobacter baumannii isolated from patients. J Infect Public Health. 14:1679–1685. 2021.PubMed/NCBI View Article : Google Scholar | |
Wang Z, Koirala B, Hernandez Y, Zimmerman M, Park S, Perlin DS and Brady SF: A naturally inspired antibiotic to target multidrug-resistant pathogens. Nature. 601:606–611. 2022.PubMed/NCBI View Article : Google Scholar | |
Zhang H, Zhu Y, Yang N, Kong Q, Zheng Y, Lv N, Chen H, Yue C, Liu Y, Li J and Ye Y: In vitro and in vivo Activity of combinations of polymyxin B with other antimicrobials against carbapenem-resistant Acinetobacter baumannii. Infect Drug Resist. 14:4657–4666. 2021.PubMed/NCBI View Article : Google Scholar | |
Tsai CC, Lin CS, Hsu CR, Chang CM, Chang IW, Lin LW, Hung CH and Wang JL: Using the Chinese herb Scutellaria barbata against extensively drug-resistant Acinetobacter baumannii infections: In vitro and in vivo studies. BMC Complement Altern Med. 18(96)2018.PubMed/NCBI View Article : Google Scholar | |
Yaghoubi S, Zekiy AO, Krutova M, Gholami M, Kouhsari E, Sholeh M, Ghafouri Z and Maleki F: Tigecycline antibacterial activity, clinical effectiveness, and mechanisms and epidemiology of resistance: Narrative review. Eur J Clin Microbiol Infect Dis. 41:1003–1022. 2022.PubMed/NCBI View Article : Google Scholar | |
Jo J and Ko KS: Tigecycline heteroresistance and resistance mechanism in clinical isolates of Acinetobacter baumannii. Microbiol Spectr. 9(e0101021)2021.PubMed/NCBI View Article : Google Scholar | |
Zhang Z, Morgan CE, Bonomo RA and Yu EW: Cryo-EM determination of eravacycline-bound structures of the ribosome and the multidrug efflux pump AdeJ of Acinetobacter baumannii. mBio. 12(e0103121)2021.PubMed/NCBI View Article : Google Scholar | |
Foong WE, Wilhelm J, Tam H-K and Pos KM: Tigecycline efflux in Acinetobacter baumannii is mediated by TetA in synergy with RND-type efflux transporters. J Antimicrob Chemother. 75:1135–1139. 2020.PubMed/NCBI View Article : Google Scholar | |
Cheng J, Kesavan DK, Vasudevan A, Cai W, Wang H, Su Z, Wang S and Xu H: Genome and transcriptome analysis of A. baumannii's ‘Transient’ increase in drug resistance under tigecycline pressure. J Glob Antimicrob Resist. 22:219–225. 2020.PubMed/NCBI View Article : Google Scholar | |
Huband MD, Mendes RE, Pfaller MA, Lindley JM, Strand GJ, Benn VJ, Zhang J, Li L, Zhang M, Tan X, et al: In vitro activity of KBP-7072, a novel third-generation tetracycline, against 531 recent geographically diverse and molecularly characterized Acinetobacter baumannii species complex isolates. Antimicrob Agents Chemother. 64:e02375–19. 2020.PubMed/NCBI View Article : Google Scholar | |
Abbey T, Vialichka A, Jurkovic M, Biagi M and Wenzler E: Activity of omadacycline alone and in combination against carbapenem-nonsusceptible Acinetobacter baumannii with varying minocycline susceptibility. Microbiol Spectr. 10:e00542–22. 2022.PubMed/NCBI View Article : Google Scholar | |
Konai MM and Haldar J: Lysine-based small molecule sensitizes rifampicin and tetracycline against multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa. ACS Infect Dis. 6:91–99. 2020.PubMed/NCBI View Article : Google Scholar | |
Pérez-Varela M, Corral J, Aranda J and Barbé J: Functional characterization of AbaQ, a novel efflux pump mediating quinolone resistance in Acinetobacter baumannii. Antimicrob Agents Chemother. 62:e00906–18. 2018.PubMed/NCBI View Article : Google Scholar | |
Mohammed MA, Salim MTA, Anwer BE, Aboshanab KM and Aboulwafa MM: Impact of target site mutations and plasmid associated resistance genes acquisition on resistance of Acinetobacter baumannii to fluoroquinolones. Sci Rep. 11(20136)2021.PubMed/NCBI View Article : Google Scholar | |
Vrancianu CO, Gheorghe I, Czobor IB and Chifiriuc MC: Antibiotic resistance profiles, molecular mechanisms and innovative treatment strategies of Acinetobacter baumannii. Microorganisms. 8(935)2020.PubMed/NCBI View Article : Google Scholar | |
Nogbou ND, Nkawane GM, Ntshane K, Wairuri CK, Phofa DT, Mokgokong KK, Ramashia M, Nchabeleng M, Obi LC and Musyoki AMz: Efflux pump activity and mutations driving multidrug resistance in Acinetobacter baumannii at a Tertiary Hospital in Pretoria, South Africa. Int J Microbiol. 2021(9923816)2021.PubMed/NCBI View Article : Google Scholar | |
Mahmoudi H, Shokoohizadeh L, Zare Fahim N, Mohamadi Bardebari A, Moradkhani S and Alikhani MY: Detection of adeABC efllux pump encoding genes and antimicrobial effect of Mentha longifolia and Menthol on MICs of imipenem and ciprofloxacin in clinical isolates of Acinetobacter baumannii. BMC Complement Med Ther. 20(92)2020.PubMed/NCBI View Article : Google Scholar | |
Aleksić Sabo V, Škorić D, Jovanović-Šanta S, Nikolić I, János C and Knežević P: Synergistic activity of bile salts and their derivatives in combination with conventional antimicrobial agents against Acinetobacter baumannii. J Ethnopharmacol. 264(113266)2021.PubMed/NCBI View Article : Google Scholar | |
Rizk M and Abou El-Khier N: Aminoglycoside resistance genes in Acinetobacter baumannii clinical isolates. Clin Lab. 65:2019.PubMed/NCBI View Article : Google Scholar | |
Jouybari MA, Ahanjan M, Mirzaei B and Goli HR: Role of aminoglycoside-modifying enzymes and 16S rRNA methylase (ArmA) in resistance of Acinetobacter baumannii clinical isolates against aminoglycosides. Rev Soc Bras Med Trop. 54(e05992020)2021.PubMed/NCBI View Article : Google Scholar | |
Sheikhalizadeh V, Hasani A, Ahangarzadeh Rezaee M, Rahmati-Yamchi M, Hasani A, Ghotaslou R and Goli HR: Comprehensive study to investigate the role of various aminoglycoside resistance mechanisms in clinical isolates of Acinetobacter baumannii. J Infect Chemother. 23:74–79. 2017.PubMed/NCBI View Article : Google Scholar | |
Juhas M, Widlake E, Teo J, Huseby DL, Tyrrell JM, Polikanov YS, Ercan O, Petersson A, Cao S, Aboklaish AF, et al: In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii. J Antimicrob Chemother. 74:944–952. 2019.PubMed/NCBI View Article : Google Scholar | |
Deng W, Fu T, Zhang Z, Jiang X, Xie J, Sun H, Hu P, Ren H, Zhou P, Liu Q and Long Q: L-lysine potentiates aminoglycosides against Acinetobacter baumannii via regulation of proton motive force and antibiotics uptake. Emerg Microbes Infect. 9:639–650. 2020.PubMed/NCBI View Article : Google Scholar | |
Kashyap S, Kaur S, Sharma P and Capalash N: Combination of colistin and tobramycin inhibits persistence of Acinetobacter baumannii by membrane hyperpolarization and down-regulation of efflux pumps. Microbes Infect. 23(104795)2021.PubMed/NCBI View Article : Google Scholar | |
Law SKK and Tan HS: The role of quorum sensing, biofilm formation, and iron acquisition as key virulence mechanisms in Acinetobacter baumannii and the corresponding anti-virulence strategies. Microbiol Res. 260(127032)2022.PubMed/NCBI View Article : Google Scholar | |
Kaushik V, Tiwari M, Joshi R and Tiwari V: Therapeutic strategies against potential antibiofilm targets of multidrug-resistant Acinetobacter baumannii. J Cell Physiol. 237:2045–2063. 2022.PubMed/NCBI View Article : Google Scholar | |
Donadu MG, Mazzarello V, Cappuccinelli P, Zanetti S, Madléna M, Nagy ÁL, Stájer A, Burián K and Gajdács M: Relationship between the biofilm-forming capacity and antimicrobial resistance in clinical Acinetobacter baumannii isolates: Results from a laboratory-based in vitro study. Microorganisms. 9(2384)2021.PubMed/NCBI View Article : Google Scholar | |
Shenkutie AM, Yao MZ, Siu GKH, Wong BKC and Leung PHM: Biofilm-induced antibiotic resistance in clinical Acinetobacter baumannii Isolates. Antibiotics (Basel). 9(817)2020.PubMed/NCBI View Article : Google Scholar | |
Selvaraj A, Valliammai A, Sivasankar C, Suba M, Sakthivel G and Pandian SK: Antibiofilm and antivirulence efficacy of myrtenol enhances the antibiotic susceptibility of Acinetobacter baumannii. Sci Rep. 10(21975)2020.PubMed/NCBI View Article : Google Scholar | |
Meng Q, Lin F and Ling B: In vitro activity of peptide antibiotics in combination with other antimicrobials on extensively drug-resistant Acinetobacter baumannii in the planktonic and biofilm cell. Front Pharmacol. 13(890955)2022.PubMed/NCBI View Article : Google Scholar | |
Salem MA, El-Shiekh RA, Hashem RA and Hassan M: In vivo antibacterial activity of star anise (Illicium verum Hook.) extract using murine MRSA skin infection model in relation to its metabolite profile. Infect Drug Resist. 14:33–48. 2021.PubMed/NCBI View Article : Google Scholar | |
Shahed-Al-Mahmud M, Roy R, Sugiokto FG, Islam MN, Lin MD, Lin LC and Lin NT: Phage φAB6-borne depolymerase combats Acinetobacter baumannii biofilm formation and infection. Antibiotics (Basel). 10(279)2021.PubMed/NCBI View Article : Google Scholar | |
Figueiredo-Godoi LMA, Garcia MT, Pinto JG, Ferreira-Strixino J, Faustino EG, Pedroso LLC and Junqueira JC: Antimicrobial photodynamic therapy mediated by fotenticine and methylene blue on planktonic growth, biofilms, and burn infections of Acinetobacter baumannii. Antibiotics (Basel). 11(619)2022.PubMed/NCBI View Article : Google Scholar | |
das Neves RC, Mortari MR, Schwartz EF, Kipnis A and Junqueira-Kipnis AP: Antimicrobial and antibiofilm effects of peptides from venom of social wasp and scorpion on multidrug-resistant Acinetobacter baumannii. Toxins (Basel). 11(216)2019.PubMed/NCBI View Article : Google Scholar |