Open Access

Effect of liraglutide on atherosclerosis in patients with impaired glucose tolerance: A double‑blind, randomized controlled clinical trial

  • Authors:
    • Liping Sun
    • Yuhong Yuan
    • Yongmei Li
    • Xiaopang Rao
  • View Affiliations

  • Published online on: April 13, 2023     https://doi.org/10.3892/etm.2023.11948
  • Article Number: 249
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glucagon‑like peptide‑1 receptor agonist liraglutide may have beneficial effects on atherosclerosis development in impaired glucose tolerance (IGT). To the best of our knowledge, however, little conclusive evidence from clinical trials has been presented. The present study aimed to investigate the effect of liraglutide on atherosclerosis progression in patients with IGT. The present study was a double‑blind, randomized controlled clinical trial. A total of 39 of patients aged 20‑75 years who were overweight or obese (BMI, 27‑40 kg/m2) and presented IGT were randomized to receive liraglutide (n=17) or lifestyle interventions (n=22) for 6 months. Serum glucose and insulin (INS) levels, lipid profile, inflammatory biomarkers and carotid intima‑media thickness (CIMT) were assessed at the start and end of each treatment. Side effects were also recorded. Liraglutide treatment was found to significantly improve glycaemia, including glycosylated hemoglobin, fasting and postprandial glucose as well as INS levels (all P<0.001). Liraglutide also significantly decreased serum total cholesterol and low‑density lipoprotein levels (all P<0.001). Furthermore, serum levels of inflammatory biomarkers, as well as CIMT, were decreased following liraglutide treatment compared with those in the lifestyle intervention group (all P<0.001). Kaplan‑Meier analysis showed that the risk of vasculopathy in the liraglutide group was lower than that in the lifestyle intervention group (log‑rank test; P=0.041). The monitoring of drug‑associated side effects indicated that the dose of liraglutide (0.6 to 1.2 mg/QD via subcutaneous injection) was safe and well‑tolerated. The present study suggested that liraglutide may slow atherosclerosis development and improve inflammatory status as well as intimal function in patients with IGT with few side effects. The trial was registered through the Chinese Clinical Trial Registry (ChiCTR; trial registration no. ChiCTR2200063693; retrospectively registered) on Sep 14, 2022.
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June-2023
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Spandidos Publications style
Sun L, Yuan Y, Li Y and Rao X: Effect of liraglutide on atherosclerosis in patients with impaired glucose tolerance: A double‑blind, randomized controlled clinical trial. Exp Ther Med 25: 249, 2023.
APA
Sun, L., Yuan, Y., Li, Y., & Rao, X. (2023). Effect of liraglutide on atherosclerosis in patients with impaired glucose tolerance: A double‑blind, randomized controlled clinical trial. Experimental and Therapeutic Medicine, 25, 249. https://doi.org/10.3892/etm.2023.11948
MLA
Sun, L., Yuan, Y., Li, Y., Rao, X."Effect of liraglutide on atherosclerosis in patients with impaired glucose tolerance: A double‑blind, randomized controlled clinical trial". Experimental and Therapeutic Medicine 25.6 (2023): 249.
Chicago
Sun, L., Yuan, Y., Li, Y., Rao, X."Effect of liraglutide on atherosclerosis in patients with impaired glucose tolerance: A double‑blind, randomized controlled clinical trial". Experimental and Therapeutic Medicine 25, no. 6 (2023): 249. https://doi.org/10.3892/etm.2023.11948