Effect of circulating miR‑126 levels on intracranial aneurysms and their predictive value for the rupture of aneurysms: A systematic review and meta‑analysis

Mathioudakis,Nikolaos; Georgakopoulou,Vasiliki Epameinondas; Paterakis,Konstantinos; Papalexis,Petros; Sklapani,Pagona; Trakas,Nikolaos; Spandidos,Demetrios A.; Fotakopoulos,George

doi:10.3892/etm.2023.12110

Effect of circulating miR‑126 levels on intracranial aneurysms and their predictive value for the rupture of aneurysms: A systematic review and meta‑analysis

Authors:
- Nikolaos Mathioudakis
- Vasiliki Epameinondas Georgakopoulou
- Konstantinos Paterakis
- Petros Papalexis
- Pagona Sklapani
- Nikolaos Trakas
- Demetrios A. Spandidos
- George Fotakopoulos
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Affiliations: Department of Renal Transplantation, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, Department of Infectious Diseases and COVID‑19 Unit, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, Department of Neurosurgery, General University Hospital of Larisa, 41221 Larisa, Greece, Unit of Endocrinology, First Department of Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, Department of Biochemistry, Sismanogleio Hospital, 15126 Athens, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Department of Neurosurgery, General University Hospital of Larisa, 41221 Larisa, Greece
Published online on: July 10, 2023 https://doi.org/10.3892/etm.2023.12110
Article Number: 411
Copyright: © Mathioudakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Intracranial aneurysm (IA) is a common cerebrovascular disease with a high risk of rupture. At present, the mechanisms underlying the formation and rupture of IAs is not clinically clear. MicroRNAs (miRNAs/miRs) are involved in the development of IAs. The present study aimed to determine the efficacy of circulating miRNA‑126 (miR‑126) levels as potential biomarkers for predicting aneurysmal ruptures. The present study searched comparative articles involving circulating miR‑126 levels and intracranial aneurysms through electronic databases from 1980 to February, 2023. Collected variables included the first author's name, covered study period, publication year, total number of patients and age, and number of males. We collected information about the expression levels of circulating miR‑126 in serum. Three articles met the eligibility criteria. The total number of patients was 379 [226 with IA rupture and 153 with non‑rupture or/+ controls (healthy)]. The circulating miR‑126 can be used as a biomarker for predicting aneurysmal rupture. Interestingly, an aneurysmal size >10 mm was associated with an IA rupture.

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