Secondary hemophagocytic lymphohistiocytosis in children (Review)
- This article is part of the special Issue: Hemophagocytic lymphohistiocytosis
- Authors:
- Chiara Benevenuta
- Ilaria Mussinatto
- Cecilia Orsi
- Fabio S. Timeus
-
Affiliations: Department of Pediatrics, Azienda Sanitaria Locale Torino 4, Chivasso Hospital, I‑10034 Turin, Italy - Published online on: July 17, 2023 https://doi.org/10.3892/etm.2023.12122
- Article Number: 423
-
Copyright: © Benevenuta et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Griffin G, Shenoi S and Hughes GC: Hemophagocytic lymphohistiocytosis: An update on pathogenesis, diagnosis, and therapy. Best Pract Res Clin Rheumatol. 34(101515)2020.PubMed/NCBI View Article : Google Scholar | |
Farquhar JW and Claireaux AE: Familial haemophagocytic reticulosis. Arch Dis Child. 27:519–525. 1952.PubMed/NCBI View Article : Google Scholar | |
Brisse E, Wouters CH and Matthys P: Advances in the pathogenesis of primary and secondary haemophagocytic lymphohistiocytosis: Differences and similarities. Br J Haematol. 174:203–217. 2016.PubMed/NCBI View Article : Google Scholar | |
Brisse E, Matthys P and Wouters CH: Understanding the spectrum of haemophagocytic lymphohistiocytosis: Update on diagnostic challenges and therapeutic options. Br J Haematol. 174:175–187. 2016.PubMed/NCBI View Article : Google Scholar | |
Price B, Lines J, Lewis D and Holland N: Haemophagocytic lymphohistiocytosis: A fulminant syndrome associated with multiorgan failure and high mortality that frequently masquerades as sepsis and shock. S Afr Med J. 104:401–406. 2014.PubMed/NCBI View Article : Google Scholar | |
Bergsten E, Horne A, Aricó M, Astigarraga I, Egeler RM, Filipovich AH, Ishii E, Janka G, Ladisch S, Lehmberg K, et al: Confirmed efficacy of etoposide and dexamethasone in HLH treatment: Long-term results of the cooperative HLH-2004 study. Blood. 130:2728–2738. 2017.PubMed/NCBI View Article : Google Scholar | |
Henter JI, Horne A, Aricó M, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J and Janka G: HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 48:124–131. 2007.PubMed/NCBI View Article : Google Scholar | |
Jordan MB, Allen CE, Greenberg J, Henry M, Hermiston ML, Kumar A, Hines M, Eckstein O, Ladisch S, Nichols KE, et al: Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: Recommendations from the North American consortium for histiocytosis (NACHO). Pediatr Blood Cancer. 66(e27929)2019.PubMed/NCBI View Article : Google Scholar | |
Ehl S, Astigarraga I, von Bahr Greenwood T, Hines M, Horne A, Ishii E, Janka G, Jordan MB, La Rosée P, Lehmberg K, et al: Recommendations for the use of etoposide-based therapy and bone marrow transplantation for the treatment of HLH: Consensus statements by the HLH steering committee of the histiocyte society. J Allergy Clin Immunol Pract. 6:1508–1517. 2018.PubMed/NCBI View Article : Google Scholar | |
Freeman HR and Ramanan AV: Review of haemophagocytic lymphohistiocytosis. Arch Dis Child. 96:688–693. 2011.PubMed/NCBI View Article : Google Scholar | |
Ishii E, Ohga S, Imashuku S, Yasukawa M, Tsuda H, Miura I, Yamamoto K, Horiuchi H, Takada K, Ohshima K, et al: Nationwide survey of hemophagocytic lymphohistiocytosis in Japan. Int J Hematol. 86:58–65. 2007.PubMed/NCBI View Article : Google Scholar | |
Cleves D, Lotero V, Medina D, Perez PM, Patiño JA, Torres-Canchala L and Olaya M: Pediatric hemophagocytic lymphohistiocytosis: A rarely diagnosed entity in a developing country. BMC Pediatr. 21(411)2021.PubMed/NCBI View Article : Google Scholar | |
Sieni E, Cetica V, Piccin A, Gherlinzoni F, Sasso FC, Rabusin M, Attard L, Bosi A, Pende D, Moretta L and Aricò M: Familial hemophagocytic lymphohistiocytosis may present during adulthood: Clinical and genetic features of a small series. PLoS One. 7(e44649)2012.PubMed/NCBI View Article : Google Scholar | |
Malinowska I, Machaczka M, Popko K, Siwicka A, Salamonowicz M and Nasiłowska-Adamska B: Hemophagocytic syndrome in children and adults. Arch Immunol Ther Exp (Warsz). 62:385–394. 2014.PubMed/NCBI View Article : Google Scholar | |
Ramos-Casals M, Brito-Zerón P, López-Guillermo A, Khamashta MA and Bosch X: Adult haemophagocytic syndrome. Lancet. 383:1503–1516. 2014.PubMed/NCBI View Article : Google Scholar | |
Macheta M, Will AM, Houghton JB and Wynn RF: Prominent dyserythropoiesis in four cases of haemophagocytic lymphohistiocytosis. J Clin Pathol. 54:961–963. 2001.PubMed/NCBI View Article : Google Scholar | |
Benson LA, Li H, Henderson LA, Solomon IH, Soldatos A, Murphy J, Bielekova B, Kennedy AL, Rivkin MJ, Davies KJ, et al: Pediatric CNS-isolated hemophagocytic lymphohistiocytosis. Neurol Neuroimmunol Neuroinflamm. 6(e560)2019.PubMed/NCBI View Article : Google Scholar | |
de Kerguenec C, Hillaire S, Molinié V, Gardin C, Degott C, Erlinger S and Valla D: Hepatic manifestations of hemophagocytic syndrome: A study of 30 cases. Am J Gastroenterol. 96:852–857. 2001.PubMed/NCBI View Article : Google Scholar | |
Amir AZ, Ling SC, Naqvi A, Weitzman S, Fecteau A, Grant D, Ghanekar A, Cattral M, Nalli N, Cutz E, et al: Liver transplantation for children with acute liver failure associated with secondary hemophagocytic lymphohistiocytosis. Liver Transpl. 22:1245–1253. 2016.PubMed/NCBI View Article : Google Scholar | |
Al-Samkari H and Berliner N: Hemophagocytic lymphohistiocytosis. Annu Rev Pathol. 13:27–49. 2018.PubMed/NCBI View Article : Google Scholar | |
Ishii E: Hemophagocytic lymphohistiocytosis in children: Pathogenesis and treatment. Front Pediatr. 4(47)2016.PubMed/NCBI View Article : Google Scholar | |
Skinner J, Yankey B and Shelton BK: Hemophagocytic lymphohistiocytosis. AACN Adv Crit Care. 30:151–164. 2019.PubMed/NCBI View Article : Google Scholar | |
Morimoto A, Nakazawa Y and Ishii E: Hemophagocytic lymphohistiocytosis: Pathogenesis, diagnosis, and management. Pediatr Int. 58:817–825. 2016.PubMed/NCBI View Article : Google Scholar | |
Jordan MB, Hildeman D, Kappler J and Marrack P: An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. Blood. 104:735–743. 2004.PubMed/NCBI View Article : Google Scholar | |
Castillo L and Carcillo J: Secondary hemophagocytic lymphohistiocytosis and severe sepsis/systemic inflammatory response syndrome/multiorgan dysfunction syndrome/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation. Pediatr Crit Care Med. 10:387–392. 2009.PubMed/NCBI View Article : Google Scholar | |
Grom AA, Horne A and De Benedetti F: Macrophage activation syndrome in the era of biologic therapy. Nat Rev Rheumatol. 12:259–268. 2016.PubMed/NCBI View Article : Google Scholar | |
Canna SW and Behrens EM: Making sense of the cytokine storm: A conceptual framework for understanding, diagnosing, and treating hemophagocytic syndromes. Pediatr Clin North Am. 59:329–344. 2012.PubMed/NCBI View Article : Google Scholar | |
Jordan MB: Emergence of targeted therapy for hemophagocytic lymphohistiocytosis. Hematologist. 15:2018. | |
Fajgenbaum DC and June CH: Cytokine storm. N Engl J Med. 383:2255–2273. 2020.PubMed/NCBI View Article : Google Scholar | |
Alonso EM, Horslen SP, Behrens EM and Doo E: Pediatric acute liver failure of undetermined cause: A research workshop. Hepatology. 65:1026–1037. 2017.PubMed/NCBI View Article : Google Scholar | |
Henter JI, Aricò M, Egeler RM, Elinder G, Favara BE, Filipovich AH, Gadner H, Imashuku S, Janka-Schaub G, Komp D, et al: HLH-94: A treatment protocol for hemophagocytic lymphohistiocytosis. HLH study group of the histiocyte society. Med Pediatr Oncol. 28:342–347. 1997.PubMed/NCBI View Article : Google Scholar | |
Johnson TS, Terrell CE, Millen SH, Katz JD, Hildeman DA and Jordan MB: Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis. J Immunol. 192:84–91. 2014.PubMed/NCBI View Article : Google Scholar | |
Mahlaoui N, Ouachée-Chardin M, de Saint Basile G, Neven B, Picard C, Blanche S and Fischer A: Immunotherapy of familial hemophagocytic lymphohistiocytosis with antithymocyte globulins: A single-center retrospective report of 38 patients. Pediatrics. 120:e622–e628. 2007.PubMed/NCBI View Article : Google Scholar | |
Latour S and Fischer A: Signaling pathways involved in the T-cell-mediated immunity against Epstein-Barr virus: Lessons from genetic diseases. Immunol Rev. 291:174–189. 2019.PubMed/NCBI View Article : Google Scholar | |
Moss DJ, Burrows SR, Khanna R, Misko IS and Sculley TB: Immune surveillance against Epstein-Barr virus. Semin Immunol. 4:97–104. 1992.PubMed/NCBI | |
Kasahara Y and Yachie A: Cell type specific infection of Epstein-Barr virus (EBV) in EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection. Crit Rev Oncol Hematol. 44:283–294. 2002.PubMed/NCBI View Article : Google Scholar | |
Balamuth NJ, Nichols KE, Paessler M and Teachey DT: Use of rituximab in conjunction with immunosuppressive chemotherapy as a novel therapy for Epstein Barr virus-associated hemophagocytic lymphohistiocytosis. J Pediatr Hematol Oncol. 29:569–573. 2007.PubMed/NCBI View Article : Google Scholar | |
Daver N, McClain K, Allen CE, Parikh SA, Otrock Z, Rojas-Hernandez C, Blechacz B, Wang S, Minkov M, Jordan MB, et al: A consensus review on malignancy-associated hemophagocytic lymphohistiocytosis in adults. Cancer. 123:3229–3240. 2017.PubMed/NCBI View Article : Google Scholar | |
Lehmberg K, Nichols KE, Henter JI, Girschikofsky M, Greenwood T, Jordan M, Kumar A, Minkov M, La Rosée P and Weitzman S: Study Group on Hemophagocytic Lymphohistiocytosis Subtypes of the Histiocyte Society. Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis associated with malignancies. Haematologica. 100:997–1004. 2015.PubMed/NCBI View Article : Google Scholar | |
Henter JI, Elinder G and Ost A: Diagnostic guidelines for hemophagocytic lymphohistiocytosis. The FHL study group of the histiocyte society. Semin Oncol. 18:29–33. 1991.PubMed/NCBI | |
Gurunathan A, Boucher AA, Mark M, Prus KM, O'Brien MM, Breese EH, Mizukawa BE, Absalon MJ, Nelson AS, Jordan MB, et al: Limitations of HLH-2004 criteria in distinguishing malignancy-associated hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 65(e27400)2018.PubMed/NCBI View Article : Google Scholar | |
Gifford CE, Weingartner E, Villanueva J, Johnson J, Zhang K, Filipovich AH, Bleesing JJ and Marsh RA: Clinical flow cytometric screening of SAP and XIAP expression accurately identifies patients with SH2D1A and XIAP/BIRC4 mutations. Cytometry B Clin Cytom. 86:263–271. 2014.PubMed/NCBI View Article : Google Scholar | |
Fardet L, Galicier L, Lambotte O, Marzac C, Aumont C, Chahwan D, Coppo P and Hejblum G: Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Arthritis Rheumatol. 66:2613–2620. 2014.PubMed/NCBI View Article : Google Scholar | |
Debaugnies F, Mahadeb B, Ferster A, Meuleman N, Rozen L, Demulder A and Corazza F: Performances of the H-score for diagnosis of hemophagocytic lymphohistiocytosis in adult and pediatric patients. Am J Clin Pathol. 145:862–870. 2016.PubMed/NCBI View Article : Google Scholar | |
Nakashima Y and Koga H: Using a Minimal Parameter Set for Early Diagnosis of Hemophagocytic lymphohistiocytosis in non-European children. Am J Case Rep. 23(e934037)2022.PubMed/NCBI View Article : Google Scholar | |
Hines MR, von Bahr Greenwood T, Beutel G, Beutel K, Hays JA, Horne A, Janka G, Jordan MB, van Laar JAM, Lachmann G, et al: Consensus-based guidelines for the recognition, diagnosis, and management of hemophagocytic lymphohistiocytosis in critically Ill children and adults. Crit Care Med. 50:860–872. 2022.PubMed/NCBI View Article : Google Scholar | |
Koç ZP, Akarsu S, Balci T and Unal K: PET/CT images of a patient with haemophagocytic lymphohistiocytosis. BMJ Case Rep. 2012(bcr0320126026)2012.PubMed/NCBI View Article : Google Scholar | |
Wei A, Lu X, Ma H, Lian H, Yang X, Zhang L, Wang D, Chen S, Zhang Q, Li Z, et al: 18F-FDG PET/CT for identifying the potential primary diseases and predicting prognosis of secondary hemophagocytic lymphohistiocytosis in children. Contrast Media Mol Imaging. 2022(4849081)2022.PubMed/NCBI View Article : Google Scholar | |
Yang X, Lu X, Liu J, Kan Y, Wang W, Zhang S, Liu L, Li J and Yang J: Development and validation of 18F-FDG PET/CT-based multivariable clinical prediction models for the identification of malignancy-associated hemophagocytic lymphohistiocytosis. Korean J Radiol. 23:466–478. 2022.PubMed/NCBI View Article : Google Scholar | |
Tabata C and Tabata R: Possible prediction of underlying lymphoma by high sIL-2R/ferritin ratio in hemophagocytic syndrome. Ann Hematol. 91:63–71. 2012.PubMed/NCBI View Article : Google Scholar | |
Tsuji T, Hirano T, Yamasaki H, Tsuji M and Tsuda H: A high sIL-2R/ferritin ratio is a useful marker for the diagnosis of lymphoma-associated hemophagocytic syndrome. Ann Hematol. 93:821–826. 2014.PubMed/NCBI View Article : Google Scholar | |
Tang Y, Xu X, Song H, Yang S, Shi S, Wei J, Pan B, Zhao F, Liao C and Luo C: Early diagnostic and prognostic significance of a specific Th1/Th2 cytokine pattern in children with haemophagocytic syndrome. Br J Haematol. 143:84–91. 2008.PubMed/NCBI View Article : Google Scholar | |
Chen Y, Wang Z, Luo Z, Zhao N, Yang S and Tang Y: Comparison of Th1/Th2 cytokine profiles between primary and secondary haemophagocytic lymphohistiocytosis. Ital J Pediatr. 42(50)2016.PubMed/NCBI View Article : Google Scholar | |
Xu XJ and Tang YM: Dilemmas in diagnosis and management of hemophagocytic lymphohistiocytosis in children. World J Pediatr. 16:333–340. 2020.PubMed/NCBI View Article : Google Scholar | |
Han XC, Ye Q, Zhang WY, Tang YM, Xu XJ and Zhang T: Cytokine profiles as novel diagnostic markers of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in children. J Crit Care. 39:72–77. 2017.PubMed/NCBI View Article : Google Scholar | |
Buatois V, Chatel L, Cons L, Lory S, Richard F, Guilhot F, Johnson Z, Bracaglia C, De Benedetti F, de Min C, et al: Use of a mouse model to identify a blood biomarker for IFNγ activity in pediatric secondary hemophagocytic lymphohistiocytosis. Transl Res. 180:37–52.e2. 2017.PubMed/NCBI View Article : Google Scholar | |
Prencipe G, Bracaglia C, Caiello I, Pascarella A, Francalanci P, Pardeo M, Meneghel A, Martini G, Rossi MN, Insalaco A, et al: The interferon-gamma pathway is selectively up-regulated in the liver of patients with secondary hemophagocytic lymphohistiocytosis. PLoS One. 14(e0226043)2019.PubMed/NCBI View Article : Google Scholar | |
Nagasawa M, Yi Z, Imashuku S, Nonoyama S, Ogawa K, Okumura K and Mizutani S: Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis. Am J Hematol. 83:222–225. 2008.PubMed/NCBI View Article : Google Scholar | |
Jenkins RW, Clarke CJ, Lucas JT Jr, Shabbir M, Wu BX, Simbari F, Mueller J, Hannun YA, Lazarchick J and Shirai K: Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis. Am J Hematol. 88:E265–E272. 2013.PubMed/NCBI View Article : Google Scholar | |
Chang YH, Lee DS, Jo HS, Cho SI, Yoon HJ, Shin S, Yoon JH, Kim HY, Hong YJ, Hong SI and Cho HI: Tumor necrosis factor alpha promoter polymorphism associated with increased susceptibility to secondary hemophagocytic lymphohistiocytosis in the Korean population. Cytokine. 36:45–50. 2006.PubMed/NCBI View Article : Google Scholar | |
Yanagimachi M, Goto H, Miyamae T, Kadota K, Imagawa T, Mori M, Sato H, Yanagisawa R, Kaneko T, Morita S, et al: Association of IRF5 polymorphisms with susceptibility to hemophagocytic lymphohistiocytosis in children. J Clin Immunol. 31:946–951. 2011.PubMed/NCBI View Article : Google Scholar | |
Horne A, Zheng C, Lorenz I, Löfstedt M, Montgomery SM, Janka G, Henter JI and Marion Schneider E: Subtyping of natural killer cell cytotoxicity deficiencies in haemophagocytic lymphohistocytosis provides therapeutic guidance. Br J Haematol. 129:658–666. 2005.PubMed/NCBI View Article : Google Scholar | |
Chang TY, Jaffray J, Woda B, Newburger PE and Usmani GN: Hemophagocytic lymphohistiocytosis with MUNC13-4 gene mutation or reduced natural killer cell function prior to onset of childhood leukemia. Pediatr Blood Cancer. 56:856–858. 2011.PubMed/NCBI View Article : Google Scholar | |
Emile JF, Abla O, Fraitag S, Horne A, Haroche J, Donadieu J, Requena-Caballero L, Jordan MB, Abdel-Wahab O, Allen CE, et al: Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood. 127:2672–2681. 2016.PubMed/NCBI View Article : Google Scholar | |
Mărginean MO, Molnar E and Chinceşan MI: Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in a small child: A case report. Medicine (Baltimore). 99(e18759)2020.PubMed/NCBI View Article : Google Scholar | |
Fałkowska A, Prądzyńska K and Drabko K: Difficult balance between EBV treatment and posttransplant immunosuppression: A successful transplant in a child with recurrent Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis. Transplant Proc. 53:2035–2039. 2021.PubMed/NCBI View Article : Google Scholar | |
Pan H, Feng DN, Song L and Sun LR: Acute myeloid leukemia following etoposide therapy for EBV-associated hemophagocytic lymphohistiocytosis: A case report and a brief review of the literature. BMC Pediatr. 16(116)2016.PubMed/NCBI View Article : Google Scholar | |
Belyea B, Hinson A, Moran C, Hwang E, Heath J and Barfield R: Spontaneous resolution of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 55:754–756. 2010.PubMed/NCBI View Article : Google Scholar | |
Lin MT, Chang HM, Huang CJ, Chen WL, Lin CY, Lin CY and Chuang SS: Massive expansion of EBV+ monoclonal T cells with CD5 down regulation in EBV-associated haemophagocytic lymphohistiocytosis. J Clin Pathol. 60:101–103. 2007.PubMed/NCBI View Article : Google Scholar | |
DomInguez-Pinilla N, Baro-Fernández M and González-Granado LI: Hemophagocytic lymphohistiocytosis secondary to Epstein Barr virus and Leishmania co-infection in a toddler. J Postgrad Med. 61:44–45. 2015.PubMed/NCBI View Article : Google Scholar | |
Gera A, Misra A, Tiwari A, Singh A and Mehndiratta S: A hungry Histiocyte, altered immunity and myriad of problems: Diagnostic challenges for Pediatric HLH. Int J Lab Hematol. 43:1443–1450. 2021.PubMed/NCBI View Article : Google Scholar | |
Oguz MM, Sahin G, Altinel Acoglu E, Polat E, Yucel H, Oztek Celebi FZ, Unsal H, Akcaboy M, Sari E and Senel S: Secondary hemophagocytic lymphohistiocytosis in pediatric patients: A single center experience and factors that influenced patient prognosis. Pediatr Hematol Oncol. 36:1–16. 2019.PubMed/NCBI View Article : Google Scholar | |
Paul T, Kalra M, Danewa A, Sachdeva P, Thatikonda KB, Sachdeva D and Sachdeva A: Pediatric hemophagocytic lymphohistiocytosis-a single center study. Indian Pediatr. 59:283–286. 2022.PubMed/NCBI | |
Imashuku S, Tabata Y, Teramura T and Hibi S: Treatment strategies for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH). Leuk Lymphoma. 39:37–49. 2000.PubMed/NCBI View Article : Google Scholar | |
Kawaguchi H, Miyashita T, Herbst H, Niedobitek G, Asada M, Tsuchida M, Hanada R, Kinoshita A, Sakurai M, Kobayashi N, et al: Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome. J Clin Invest. 92:1444–1450. 1993.PubMed/NCBI View Article : Google Scholar | |
Imashuku S: Clinical features and treatment strategies of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. Crit Rev Oncol Hematol. 44:259–272. 2002.PubMed/NCBI View Article : Google Scholar | |
Lohana C, Jhatial MA and Bokhari SWI: A challenging case of haemophagocytic lymphohistiocytosis (HLH) secondary to CMV infection in an adolescent with B-acute lymphoblastic leukemia. J Coll Physicians Surg Pak. 31:1011–1012. 2021.PubMed/NCBI View Article : Google Scholar | |
Pessoa FS, Gonçalves VC and Lacerda EMDCB: Haemophagocytic lymphohistiocytosis secondary to intrauterine cytomegalovirus infection. Rev Inst Med Trop Sao Paulo. 63(e15)2021.PubMed/NCBI View Article : Google Scholar | |
Eldem İ, Al-Rahawan MM and Levent F: How to treat cytomegalovirus-induced hemophagocytic lymphohistiocytosis in a child with leukemia. J Pediatr Hematol Oncol. 42:313–315. 2020.PubMed/NCBI View Article : Google Scholar | |
Silwedel C, Frieauff E, Thomas W, Liese JG and Speer CP: Secondary haemophagocytic lymphohistiocytosis triggered by postnatally acquired cytomegalovirus infection in a late preterm infant. Infection. 45:355–359. 2017.PubMed/NCBI View Article : Google Scholar | |
Hasan MR, Sundaram MS, Sundararaju S, Tsui KM, Karim MY, Roscoe D, Imam O, Janahi MA, Thomas E, Dobson S, et al: Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: A case report. BMC Infect Dis. 20(237)2020.PubMed/NCBI View Article : Google Scholar | |
Gur G, Cakar N, Uncu N, Ayar G, Basaran O, Taktak A, Koksoy AY, Acar B and Caycı FS: Hemophagocytic lymphohistiocytosis secondary to Varicella zoster infection in a child with Henoch-Schönlein purpura. Pediatr Int. 57:e37–e38. 2015.PubMed/NCBI View Article : Google Scholar | |
Krishnappa A, Munusamy J, Ray S, Rameshbabu M, Bhatia P, Roy PS, Sundaram V and Kumar P: Neonatal dengue with HLH: Perks of early diagnosis and management. J Pediatr Hematol Oncol. 43:e770–e773. 2021.PubMed/NCBI View Article : Google Scholar | |
Agrawal G, Wazir S, Sachdeva A and Kumar S: Primary dengue infection triggered haemophagocytic lymphohistiocytosis in a neonate. BMJ Case Rep. 13(e236881)2020.PubMed/NCBI View Article : Google Scholar | |
Krithika MV, Amboiram P, Latha SM, Ninan B, Suman FR and Scott J: Neonate with haemophagocytic lymphohistiocytosis secondary to dengue infection: A case report. Trop Doct. 47:253–255. 2017.PubMed/NCBI View Article : Google Scholar | |
Jasmine YSY, Lee SL and Kan FK: Infection associated haemophagocytic syndrome in severe dengue infection-a case series in a district hospital. Med J Malaysia. 72:62–64. 2017.PubMed/NCBI | |
Phuakpet K, Sanpakit K, Vathana N, Takpradit C, Chokephaibulkit K and Viprakasit V: Hemophagocytic lymphohistiocytosis following dengue hemorrhagic fever in Hb H/Hb Constant Spring patient. Pediatr Int. 57:763–765. 2015.PubMed/NCBI View Article : Google Scholar | |
Joshi R, Phatarpekar A, Currimbhoy Z and Desai M: Haemophagocytic lymphohistiocytosis: A case series from Mumbai. Ann Trop Paediatr. 31:135–140. 2011.PubMed/NCBI View Article : Google Scholar | |
Nandhakumar D, Loganatha A, Sivasankaran M, Sivabalan S and Munirathnam D: Hemophagocytic lymphohistiocytosis in children. Indian J Pediatr. 87:526–531. 2020.PubMed/NCBI View Article : Google Scholar | |
Simon AC, Delhi Kumar CG, Basu D and Ramesh Kumar R: Hemophagocytic lymphohistiocytosis in children: Clinical profile and outcome. J Pediatr Hematol Oncol. 42:e281–e285. 2020.PubMed/NCBI View Article : Google Scholar | |
Gayretli Aydin ZG, Yesilbas O, Reis GP and Guven B: The first pediatric case of hemophagocytic lymphohistiocytosis secondary to Crimean-Congo haemorrhagic fever successfully treated with therapeutic plasma exchange accompanying ribavirin and intravenous immunoglobulin. J Clin Apher. 36:780–784. 2021.PubMed/NCBI View Article : Google Scholar | |
Bıçakçı Z, Tavil B, Tezer H and Olcay L: Hemophagocytosis in a case with Crimean-Congo hemorrhagic fever and an overview of possible pathogenesis with current evidence. Turk J Pediatr. 55:344–348. 2013.PubMed/NCBI | |
Mancao MY, Imran H, Chandra S, Estrada B, Figarola M, Sosnowski J and Vidal R: Eastern equine encephalitis virus infection and hemophagocytic lymphohistiocytosis in a 5-month-old infant. Pediatr Infect Dis J. 28:543–545. 2009.PubMed/NCBI View Article : Google Scholar | |
Bay A, Bosnak V, Leblebisatan G, Yavuz S, Yilmaz F and Hizli S: Hemophagocytic lymphohistiocytosis in 2 pediatric patients secondary to hepatitis A virus infection. Pediatr Hematol Oncol. 29:211–214. 2012.PubMed/NCBI View Article : Google Scholar | |
Jianguo L, Zhixuan Z, Rong L and Xiaodong S: Ruxolitinib in alleviating the cytokine storm of hemophagocytic lymphohistiocytosis. Pediatrics. 146(e20191301)2020.PubMed/NCBI View Article : Google Scholar | |
Chiperi LE, Ionescu AD, Marcu CT, Itu-Mureşan C and Pantelemon C: Hemophagocytic lymphohistiocytosis in a child with human immunodeficiency virus infection-a case report. Rom J Morphol Embryol. 62:279–282. 2021.PubMed/NCBI View Article : Google Scholar | |
Censoplano N, Gorga S, Waldeck K, Stillwell T, Rabah-Hammad R and Flori H: Neonatal adenovirus infection complicated by hemophagocytic lymphohistiocytosis syndrome. Pediatrics. 141 (Suppl 5):S475–S480. 2018.PubMed/NCBI View Article : Google Scholar | |
Otto WR, Behrens EM, Teachey DT, Lamson DM, Barrett DM, Bassiri H, Lambert MP, Mount S, Petrosa WL, Romberg N, et al: Human adenovirus 7-associated hemophagocytic lymphohistiocytosis-like illness: Clinical and virological characteristics in a cluster of five pediatric cases. Clin Infect Dis. 73:e1532–e1538. 2021.PubMed/NCBI View Article : Google Scholar | |
Zhang XY, Ye XW, Feng DX, Han J, Li D and Zhang C: Hemophagocytic lymphohistiocytosis induced by severe pandemic influenza A (H1N1) 2009 virus infection: A case report. Case Rep Med. 2011(951910)2011.PubMed/NCBI View Article : Google Scholar | |
Shrestha B, Omran A, Rong P and Wang W: Report of a fatal pediatric case of hemophagocytic lymphohistiocytosis associated with pandemic influenza A (H1N1) infection in 2009. Pediatr Neonatol. 56:189–192. 2015.PubMed/NCBI View Article : Google Scholar | |
Ozdemir H, Çiftçi E, Ince EU, Ertem M, Ince E and Doğru U: Hemophagocytic lymphohistiocytosis associated with 2009 pandemic influenza A (H1N1) virus infection. J Pediatr Hematol Oncol. 33:135–137. 2011.PubMed/NCBI View Article : Google Scholar | |
Tholin B, Hauge MT, Aukrust P, Fehrle L and Tvedt TH: Hemophagocytic lymphohistiocytosis in a patient with COVID-19 treated with tocilizumab: A case report. J Med Case Rep. 14(187)2020.PubMed/NCBI View Article : Google Scholar | |
Hakim NN, Chi J, Olazagasti C and Liu JM: Secondary hemophagocytic lymphohistiocytosis versus cytokine release syndrome in severe COVID-19 patients. Exp Biol Med (Maywood). 246:5–9. 2021.PubMed/NCBI View Article : Google Scholar | |
Jose PMM, Paola ZS, Eduardo DG, Arturo SMMO and Fernando BG: A case of coinfection of a pediatric patient with acute SARS-COV-2 with MIS-C and severe DENV-2 in Mexico: A case report. BMC Infect Dis. 21(1072)2021.PubMed/NCBI View Article : Google Scholar | |
Mahdavi M, Hejri GM, Pouraliakbar H, Shahzadi H, Hesami M and Houshmand G: Cytokine storm after heart transplantation in COVID-19-related haemophagocytic lymphohistiocytosis (HLH). ESC Heart Fail. 9:219–223. 2022.PubMed/NCBI View Article : Google Scholar | |
El-Isa HZ, Khader OA, Khader M, Ashour BA, Azzam MI and Badran EF: Secondary hemophagocytic lymphohistiocytosis in a neonate with SARS-CoV-2 infection. Am J Case Rep. 23(e934839)2022.PubMed/NCBI View Article : Google Scholar | |
Mittal J, Kumar P, Goyal JP and Purohit A: Haemophagocytic lymphohistiocytosis secondary to brucellosis in a young child. BMJ Case Rep. 14(e240759)2021.PubMed/NCBI View Article : Google Scholar | |
Pekpak E and Sirvan Cetin B: Secondary hemophagocytic lymphohistocytosis in a child with brucellosis. J Pediatr Hematol Oncol. 39:e501–e503. 2017.PubMed/NCBI View Article : Google Scholar | |
Yaman Y, Gözmen S, Özkaya AK, Oymak Y, Apa H, Vergin C and Devrim İ: Secondary hemophagocytic lymphohistiocytosis in children with brucellosis: Report of three cases. J Infect Dev Ctries. 9:1172–1176. 2015.PubMed/NCBI View Article : Google Scholar | |
Banday AZ, Mehta R, Vignesh P, Kanaujia R, Durgadevi S, Angrup A, Kumar N, Ray P and Suri D: Case Report: Ceftriaxone-resistant invasive Salmonella enteritidis infection with secondary hemophagocytic lymphohistiocytosis: A contrast with enteric fever. Am J Trop Med Hyg. 103:2515–2517. 2020.PubMed/NCBI View Article : Google Scholar | |
Maheshwari P, Chhabra R and Yadav P: Perinatal tuberculosis associated hemophagocytic lymphohistiocytosis. Indian J Pediatr. 79:1228–1229. 2012.PubMed/NCBI View Article : Google Scholar | |
Choi YB and Yi DY: Fatal case of hemophagocytic lymphohistiocytosis associated with group B streptococcus sepsis: A case report. Medicine (Baltimore). 97(e12210)2018.PubMed/NCBI View Article : Google Scholar | |
Liu SS, Wang Y, Xue L, Ma C and Li CH: Hemophagocytic lymphohistiocytosis due to Streptococcus suis in a 12-year-old girl: A case report. Medicine (Baltimore). 98(e15136)2019.PubMed/NCBI View Article : Google Scholar | |
Sahu SK, Behera JR and Yadav SK: Scrub typhus with secondary hemophagocytic lymphohistiocytosis in a 3-month-old child from a tertiary care hospital of Odisha. Indian J Public Health. 65:85–86. 2021.PubMed/NCBI View Article : Google Scholar | |
Han DK, Baek HJ, Shin MG, Kim JW, Kook H and Hwang TJ: Scrub typhus-associated severe hemophagocytic lymphohistiocytosis with encephalomyelitis leading to permanent sequelae: A case report and review of the literature. J Pediatr Hematol Oncol. 34:531–533. 2012.PubMed/NCBI View Article : Google Scholar | |
Agrwal S, Dabas A, Mantan M and Yadav S: Hemophagocytic lymphohistiocytosis with neurological manifestations in an infant with scrub typhus: A rare fatal occurrence. Trop Doct. 49:52–53. 2019.PubMed/NCBI View Article : Google Scholar | |
Pazhaniyandi S, Lenin R and Sivathanu S: Hemophagocytic lymphohistiocytosis with a leukemoid reaction in an infant with scrub typhus. J Infect Public Health. 8:626–629. 2015.PubMed/NCBI View Article : Google Scholar | |
Otrock ZK, Gonzalez MD and Eby CS: Ehrlichia-induced hemophagocytic lymphohistiocytosis: A case series and review of literature. Blood Cells Mol Dis. 55:191–193. 2015.PubMed/NCBI View Article : Google Scholar | |
Cheng A, Williams F, Fortenberry J, Preissig C, Salinas S and Kamat P: Use of extracorporeal support in hemophagocytic lymphohistiocytosis secondary to ehrlichiosis. Pediatrics. 138(e20154176)2016.PubMed/NCBI View Article : Google Scholar | |
Burns S, Saylors R and Mian A: Hemophagocytic lymphohistiocytosis secondary to Ehrlichia chaffeensis infection: A case report. J Pediatr Hematol Oncol. 32:e142–143. 2010.PubMed/NCBI View Article : Google Scholar | |
Singh NS, Pagano AL, Hays AJ, Kats A, Dahl SM, Warady BA, Beins NT and Yin DE: Ehrlichia-induced hemophagocytic lymphohistiocytosis in a pediatric kidney transplant recipient. Pediatr Transplant. 26(e14134)2022.PubMed/NCBI View Article : Google Scholar | |
Cabler SS, Hogan PG, Fritz SA, Bednarski JJ and Hunstad DA: Incidence and treatment of hemophagocytic lymphohistiocytosis in hospitalized children with Ehrlichia infection. Pediatr Blood Cancer. 67(e28436)2020.PubMed/NCBI View Article : Google Scholar | |
Tsuge M, Miyamoto M, Miyawaki R, Kondo Y and Tsukahara H: Hemophagocytic lymphohistiocytosis complicating invasive pneumococcal disease: A pediatric case report. BMC Pediatr. 20(15)2020.PubMed/NCBI View Article : Google Scholar | |
Poudel A, Lew J, Slayton W and Dharnidharka VR: Bartonella henselae infection inducing hemophagocytic lymphohistiocytosis in a kidney transplant recipient. Pediatr Transplant. 18:E83–E87. 2014.PubMed/NCBI View Article : Google Scholar | |
Edner J, Rudd E, Zheng C, Dahlander A, Eksborg S, Schneider EM, Edner A and Henter JI: Severe bacteria-associated hemophagocytic lymphohistiocytosis in an extremely premature infant. Acta Paediatr. 96:1703–1706. 2007.PubMed/NCBI View Article : Google Scholar | |
Karapinar DY, Karadaş N, Yazici P, Polat SH and Karapinar B: Trichosporon asahii, sepsis, and secondary hemophagocytic lymphohistiocytosis in children with hematologic malignancy. Pediatr Hematol Oncol. 31:282–284. 2014.PubMed/NCBI View Article : Google Scholar | |
Guo F, Kang L and Xu M: A case of pediatric visceral leishmaniasis-related hemophagocytic lymphohistiocytosis diagnosed by mNGS. Int J Infect Dis. 97:27–29. 2020.PubMed/NCBI View Article : Google Scholar | |
Guo X, Chen N, Wang TY, Zhou YC, Li Q and Gao J: Visceral leishmaniasis associated hemophagocytic lymphohistiocytosis: Report of four childhood cases. Zhonghua Er Ke Za Zhi. 49:550–553. 2011.PubMed/NCBI(In Chinese). | |
Bouguila J, Chabchoub I, Moncef Y, Mlika A, Saghrouni F, Boughamoura L and Essoussi AS: Treatment of severe hemophagocytic syndrome associated with visceral leishmaniasis. Arch Pediatr. 17:1566–1570. 2010.PubMed/NCBI View Article : Google Scholar : (In French). | |
Castberg FC, Poulsen A, Petersen BL and Lausen B: Visceral leishmaniasis in two children after vacation in Southern Europe. Ugeskr Laeger. 175:2193–2194. 2013.PubMed/NCBI(In Danish). | |
Rajagopala S, Dutta U, Chandra KSP, Bhatia P, Varma N and Kochhar R: Visceral leishmaniasis associated hemophagocytic lymphohistiocytosis-case report and systematic review. J Infect. 56:381–388. 2008.PubMed/NCBI View Article : Google Scholar | |
Ay Y, Yildiz B, Unver H, Karapinar DY and Vardar F: Hemophagocytic lymphohistiocytosis associated with H1N1 virus infection and visceral leishmaniasis in a 4.5-month-old infant. Rev Soc Bras Med Trop. 45:407–409. 2012.PubMed/NCBI | |
Mottaghipisheh H, Kalantar K, Amanati A, Shokripour M, Shahriari M, Zekavat OR, Zareifar S, Karimi M, Haghpanah S and Bordbar M: Comparison of the clinical features and outcome of children with hemophagocytic lymphohistiocytosis (HLH) secondary to visceral leishmaniasis and primary HLH: A single-center study. BMC Infect Dis. 21(732)2021.PubMed/NCBI View Article : Google Scholar | |
de Carvalho FHG, Lula JF, Teles LF, Caldeira AP and de Carvalho SFG: Hemophagocytic lymphohistiocytosis secondary to visceral leishmaniasis in an endemic area in the north of Minas Gerais, Brazil. Rev Soc Bras Med Trop. 53(e20190491)2020.PubMed/NCBI View Article : Google Scholar | |
Shi Q, Huang M, Li X, Zheng X, Wang F, Zou Y, Wang L and Jia J: Clinical and laboratory characteristics of hemophagocytic lymphohistiocytosis induced by Leishmania infantum infection. PLoS Negl Trop Dis. 15(e0009944)2021.PubMed/NCBI View Article : Google Scholar | |
Srivatsav S, Mahalingam S, Ramineni P and Manya S: Dengue and Plasmodium falciparum coinfection with secondary hemophagocytic lymphohistiocytosis in a 3-year-old boy: A clinical conundrum. J Pediatr Hematol Oncol. 44:e253–e254. 2022.PubMed/NCBI View Article : Google Scholar | |
Padhi S, Varghese RGB, Ramdas A, Phansalkar MD and Sarangi R: Hemophagocytic lymphohistiocytosis: Critical reappraisal of a potentially under-recognized condition. Front Med. 7:492–498. 2013.PubMed/NCBI View Article : Google Scholar | |
Lehmberg K, Sprekels B, Nichols KE, Woessmann W, Müller I, Suttorp M, Bernig T, Beutel K, Bode SF, Kentouche K, et al: Malignancy-associated haemophagocytic lymphohistiocytosis in children and adolescents. Br J Haematol. 170:539–549. 2015.PubMed/NCBI View Article : Google Scholar | |
O'Brien MM, Lee-Kim Y, George TI, McClain KL, Twist CJ and Jeng M: Precursor B-cell acute lymphoblastic leukemia presenting with hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 50:381–383. 2008.PubMed/NCBI View Article : Google Scholar | |
Celkan T, Berrak S, Kazanci E, Ozyürek E, Unal S, Uçar C, Yilmaz S and Gürgey A: Malignancy-associated hemophagocytic lymphohistiocytosis in pediatric cases: A multicenter study from Turkey. Turk J Pediatr. 51:207–213. 2009.PubMed/NCBI | |
Strenger V, Merth G, Lackner H, Aberle SW, Kessler HH, Seidel MG, Schwinger W, Sperl D, Sovinz P, Karastaneva A, et al: Malignancy and chemotherapy induced haemophagocytic lymphohistiocytosis in children and adolescents-a single centre experience of 20 years. Ann Hematol. 97:989–998. 2018.PubMed/NCBI View Article : Google Scholar | |
Chellapandian D, Hines MR, Zhang R, Jeng M, van den Bos C, Santa-María López V, Lehmberg K, Sieni E, Wang Y, Nakano T, et al: A multicenter study of patients with multisystem Langerhans cell histiocytosis who develop secondary hemophagocytic lymphohistiocytosis. Cancer. 125:963–971. 2019.PubMed/NCBI View Article : Google Scholar | |
Chinn IK, Eckstein OS, Peckham-Gregory EC, Goldberg BR, Forbes LR, Nicholas SK, Mace EM, Vogel TP, Abhyankar HA, Diaz MI, et al: Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis. Blood. 132:89–100. 2018.PubMed/NCBI View Article : Google Scholar | |
Cader FZ, Colmenero I and Mussai F: Hemophagocytic lymphohistiocytosis associated with 2 cases of pediatric lymphocyte-depleted classic hodgkin lymphoma. J Pediatr Hematol Oncol. 41:e341–e345. 2019.PubMed/NCBI View Article : Google Scholar | |
Huang Z, Jia Y, Zuo Y, Wu J, Lu A and Zhang L: Malignancy-associated hemophagocytic lymphohistiocytosis in children: A 10-year experience of a single pediatric hematology center. Hematology. 25:389–399. 2020.PubMed/NCBI View Article : Google Scholar | |
Sakamoto K, Osumi T, Yoshimura S, Shimizu S, Kato M, Tomizawa D, Fukuda A, Sakamoto S, Nakano N, Yoshioka T, et al: Living-donor liver transplantation providing an adequate chemotherapy for a pediatric patient with anaplastic large cell lymphoma complicated with liver failure due to the aggravation of biliary hepatopathy by secondary hemophagocytic lymphohistiocytosis. Int J Hematol. 112:900–905. 2020.PubMed/NCBI View Article : Google Scholar | |
Teshigawara S, Katada Y, Maeda Y, Yoshimura M, Kudo-Tanaka E, Tsuji S, Harada Y, Matsushita M, Ohshima S, Watanabe K, et al: Hemophagocytic lymphohistiocytosis with leukoencephalopathy in a patient with dermatomyositis accompanied with peripheral T-cell lymphoma: A case report. J Med Case Rep. 10(212)2016.PubMed/NCBI View Article : Google Scholar | |
Sinno MG, Rosen D and Wittler R: Concomitant presentation of hemophagocytic lymphohistiocytosis and posttransplant lymphoproliferative disease-like lymphoma in a mildly immunosuppressed leukemia patient: An unusual association. Pediatr Blood Cancer. 63:1474–1476. 2016.PubMed/NCBI View Article : Google Scholar | |
McCall CM, Mudali S, Arceci RJ, Small D, Fuller S, Gocke CD, Vuica-Ross M, Burns KH, Borowitz MJ and Duffield AS: Flow cytometric findings in hemophagocytic lymphohistiocytosis. Am J Clin Pathol. 137:786–794. 2012.PubMed/NCBI View Article : Google Scholar | |
Zheng F, Jia Y, Zhang L and Qin J: Hemophagocytic lymphohistiocytosis secondary to juvenile myelomonocytic leukemia: A case report and review of the literature. J Pediatr Hematol Oncol. 44:e580–e584. 2022.PubMed/NCBI View Article : Google Scholar | |
Farias MG, Freitas PAC, Spagnol F, Souza MV, Alegretti AP, Riegel M, Taniguchi ANR and Daudt LE: Hemophagocytosis by blasts in a child with acute monocytic leukemia after chemotherapy. Rev Paul Pediatr. 39(e2019290)2021.PubMed/NCBI View Article : Google Scholar : (In Portuguese, English). | |
Dokmanovic L, Krstovski N, Jankovic S and Janic D: Hemophagocytic lymphohistiocytosis arising in a child with Langerhans cell histiocytosis. Turk J Pediatr. 56:452–457. 2014.PubMed/NCBI | |
Murphy EP, Mo J and Yoon JM: Secondary hemophagocytic lymphohistiocytosis in a patient with favorable histology wilms tumor. J Pediatr Hematol Oncol. 37:e494–e496. 2015.PubMed/NCBI View Article : Google Scholar | |
Nascimento FA, Nery J, Trennepohl J and Pianovski MAD: Hemophagocytic lymphohistiocytosis after initiation of chemotherapy for bilateral adrenal neuroblastoma. J Pediatr Hematol Oncol. 38:e13–e15. 2016.PubMed/NCBI View Article : Google Scholar | |
Tang X, Guo X, Gao J, Sun JJ and Wan Z: Hemophagocytic lymphohistiocytosis in langerhans cell histiocytosis: A case series and literature review. J Pediatr Hematol Oncol. 44:e20–e25. 2022.PubMed/NCBI View Article : Google Scholar | |
Devecioglu O, Anak S, Atay D, Aktan P, Devecioglu E, Ozalp B and Saribeyoglu E: Pediatric acute lymphoblastic leukemia complicated by secondary hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 53:491–492. 2009.PubMed/NCBI View Article : Google Scholar | |
Henderson LA and Cron RQ: Macrophage activation syndrome and secondary hemophagocytic lymphohistiocytosis in childhood inflammatory disorders: Diagnosis and management. Paediatr Drugs. 22:29–44. 2020.PubMed/NCBI View Article : Google Scholar | |
Sandler RD, Tattersall RS, Schoemans H, Greco R, Badoglio M, Labopin M, Alexander T, Kirgizov K, Rovira M, Saif M, et al: Diagnosis and management of secondary HLH/MAS following HSCT and CAR-T cell therapy in adults; A review of the literature and a survey of practice within EBMT centres on behalf of the autoimmune diseases working party (ADWP) and transplant complications working party (TCWP). Front Immunol. 11(524)2020.PubMed/NCBI View Article : Google Scholar | |
Teachey DT, Lacey SF, Shaw PA, Melenhorst JJ, Maude SL, Frey N, Pequignot E, Gonzalez VE, Chen F, Finklestein J, et al: Identification of predictive biomarkers for cytokine release syndrome after chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Cancer Discov. 6:664–679. 2016.PubMed/NCBI View Article : Google Scholar | |
Neelapu SS, Tummala S, Kebriaei P, Wierda W, Gutierrez C, Locke FL, Komanduri KV, Lin Y, Jain N, Daver N, et al: Chimeric antigen receptor T-cell therapy-assessment and management of toxicities. Nat Rev Clin Oncol. 15:47–62. 2018.PubMed/NCBI View Article : Google Scholar | |
Lichtenstein DA, Schischlik F, Shao L, Steinberg SM, Yates B, Wang HW, Wang Y, Inglefield J, Dulau-Florea A, Ceppi F, et al: Characterization of HLH-like manifestations as a CRS variant in patients receiving CD22 CAR T cells. Blood. 138:2469–2484. 2021.PubMed/NCBI View Article : Google Scholar | |
Hines MR, Keenan C, Maron Alfaro G, Cheng C, Zhou Y, Sharma A, Hurley C, Nichols KE, Gottschalk S, Triplett BM and Talleur AC: Hemophagocytic lymphohistiocytosis-like toxicity (carHLH) after CD19-specific CAR T-cell therapy. Br J Haematol. 194:701–707. 2021.PubMed/NCBI View Article : Google Scholar | |
Maude SL, Laetsch TW, Buechner J, Rives S, Boyer M, Bittencourt H, Bader P, Verneris MR, Stefanski HE, Myers GD, et al: Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia. N Engl J Med. 378:439–448. 2018.PubMed/NCBI View Article : Google Scholar | |
Xu XJ and Tang YM: Cytokine release syndrome in cancer immunotherapy with chimeric antigen receptor engineered T cells. Cancer Lett. 343:172–178. 2014.PubMed/NCBI View Article : Google Scholar | |
Singh N, Hofmann TJ, Gershenson Z, Levine BL, Grupp SA, Teachey DT and Barrett DM: Monocyte lineage-derived IL-6 does not affect chimeric antigen receptor T-cell function. Cytotherapy. 19:867–880. 2017.PubMed/NCBI View Article : Google Scholar | |
Giavridis T, van der Stegen SJC, Eyquem J, Hamieh M, Piersigilli A and Sadelain M: CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade. Nat Med. 24:731–738. 2018.PubMed/NCBI View Article : Google Scholar | |
Norelli M, Camisa B, Barbiera G, Falcone L, Purevdorj A, Genua M, Sanvito F, Ponzoni M, Doglioni C, Cristofori P, et al: Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells. Nat Med. 24:739–748. 2018.PubMed/NCBI View Article : Google Scholar | |
Liu Y, Fang Y, Chen X, Wang Z, Liang X, Zhang T, Liu M, Zhou N, Lv J, Tang K, et al: Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome. Sci Immunol. 5(eaax7969)2020.PubMed/NCBI View Article : Google Scholar | |
Teachey DT, Rheingold SR, Maude SL, Zugmaier G, Barrett DM, Seif AE, Nichols KE, Suppa EK, Kalos M, Berg RA, et al: Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy. Blood. 121:5154–5157. 2013.PubMed/NCBI View Article : Google Scholar | |
Winkler U, Jensen M, Manzke O, Schulz H, Diehl V and Engert A: Cytokine-release syndrome in patients with B-cell chronic lymphocytic leukemia and high lymphocyte counts after treatment with an anti-CD20 monoclonal antibody (rituximab, IDEC-C2B8). Blood. 94:2217–2224. 1999.PubMed/NCBI | |
Asano T, Kogawa K, Morimoto A, Ishida Y, Suzuki N, Ohga S, Kudo K, Ohta S, Wakiguchi H, Tabuchi K, et al: Hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation in children: A nationwide survey in Japan. Pediatr Blood Cancer. 59:110–114. 2012.PubMed/NCBI View Article : Google Scholar | |
Noguchi M and Inagaki J: Hemophagocytic lymphohistiocytosis and graft failure following unrelated umbilical cord blood transplantation in children. J Pediatr Hematol Oncol. 42:e440–e444. 2020.PubMed/NCBI View Article : Google Scholar | |
Jarchin L, Chu J, Januska M, Merola P and Arnon R: Autoimmune hemolytic anemia: An unusual presentation of hemophagocytic lymphohistiocytosis in a pediatric post-liver transplant patient. Pediatr Transplant. 22(e13281)2018.PubMed/NCBI View Article : Google Scholar | |
Nakajima K, Hiejima E, Nihira H, Kato K, Honda Y, Izawa K, Kawabata N, Kato I, Ogawa E, Sonoda M, et al: Case report: A case of Epstein-Barr virus-associated acute liver failure requiring hematopoietic cell transplantation after emergent liver transplantation. Front Immunol. 13(825806)2022.PubMed/NCBI View Article : Google Scholar | |
Jha B, Mohan N, Gajendra S, Sachdev R, Goel S, Sahni T, Raina V and Soin A: Prompt diagnosis and management of Epstein-Barr virus-associated post-transplant lymphoproliferative disorder and hemophagocytosis: A dreaded complication in a post-liver transplant child. Pediatr Transplant. 19:E177–E180. 2015.PubMed/NCBI View Article : Google Scholar | |
Matsuda K, Toyama K, Toya T, Ikemura M, Nakamura F and Kurokawa M: Reactivation of hemophagocytic lymphohistiocytosis triggered by antithymocyte globulin. Intern Med. 57:583–586. 2018.PubMed/NCBI View Article : Google Scholar | |
Ali S, AlThubaiti S, Renzi S, Krueger J, Chiang KY, Naqvi A, Schechter T, Punnett A and Ali M: Hemophagocytic lymphohistiocytosis is a sign of poor outcome in pediatric Epstein-Barr virus-associated post-transplant lymphoproliferative disease after allogeneic hematopoietic stem cell transplantation. Pediatr Transplant. 23(e13319)2019.PubMed/NCBI View Article : Google Scholar | |
Park M, Yun YJ, Woo SI, Lee JW, Chung NG and Cho B: Rotavirus-associated hemophagocytic lymphohistiocytosis (HLH) after hematopoietic stem cell transplantation for familial HLH. Pediatr Int. 57:e77–e80. 2015.PubMed/NCBI View Article : Google Scholar | |
Salvador C, Meister B, Larcher H, Crazzolara R and Kropshofer G: Hemophagocytic lymphohistiocytosis after allogeneic bone marrow transplantation during chronic norovirus infection. Hematol Oncol. 32:102–106. 2014.PubMed/NCBI View Article : Google Scholar | |
Hattori N, Sato M, Uesugi Y, Nakata A, Sasaki Y, Shimada S, Watanuki M, Fujiwara S, Kawaguchi Y, Arai N, et al: Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults. Int J Hematol. 113:693–702. 2021.PubMed/NCBI View Article : Google Scholar | |
Stefanou C, Tzortzi C, Georgiou F and Timiliotou C: Combining an antiviral with rituximab in EBV-related haemophagocytic lymphohistiocytosis led to rapid viral clearance; and a comprehensive review. BMJ Case Rep. 2016(bcr2016216488)2016.PubMed/NCBI View Article : Google Scholar | |
Farias-Moeller R, LaFrance-Corey R, Bartolini L, Wells EM, Baker M, Doslea A, Suslovic W, Greenberg J, Carpenter JL and Howe CL: Fueling the FIRES: Hemophagocytic lymphohistiocytosis in febrile infection-related epilepsy syndrome. Epilepsia. 59:1753–1763. 2018.PubMed/NCBI View Article : Google Scholar | |
Dandoy C and Grimley M: Secondary hemophagocytic lymphohistiocytosis (HLH) from a presumed brown recluse spider bite. J Clin Immunol. 34:544–547. 2014.PubMed/NCBI View Article : Google Scholar | |
Alabbas F, Elyamany G, Alanzi T, Ali TB, Albatniji F and Alfaraidi H: Wolman's disease presenting with secondary hemophagocytic lymphohistiocytosis: A case report from Saudi Arabia and literature review. BMC Pediatr. 21(72)2021.PubMed/NCBI View Article : Google Scholar | |
Schüller S, Attarbaschi A, Berger A, Hutter C, Klebermass-Schrehof K and Steiner M: Hemophagocytic lymphohistiocytosis triggered by Gaucher disease in a preterm neonate. Pediatr Hematol Oncol. 33:462–467. 2016.PubMed/NCBI View Article : Google Scholar | |
Gokce M, Unal O, Hismi B, Gumruk F, Coskun T, Balta G, Unal S, Cetin M, Kalkanoglu-Sivri HS, Dursun A and Tokatlı A: Secondary hemophagocytosis in 3 patients with organic acidemia involving propionate metabolism. Pediatr Hematol Oncol. 29:92–98. 2012.PubMed/NCBI View Article : Google Scholar | |
Erdol S, Ture M, Baytan B, Yakut T and Saglam H: An unusual case of LCHAD deficiency presenting with a clinical picture of hemophagocytic lymphohistiocytosis: Secondary HLH or coincidence? J Pediatr Hematol Oncol. 38:661–662. 2016.PubMed/NCBI View Article : Google Scholar | |
Düzenli Kar Y, Özdemir ZC, Kiral E, Kiliç Yildirim G, Dinleyici EÇ and Bör Ö: Hemophagocytic lymphohystiocytosis associated with type Ia glycogen storage disease. J Pediatr Hematol Oncol. 41:e260–e262. 2019.PubMed/NCBI View Article : Google Scholar | |
Santos Silva E, Klaudel-Dreszler M, Bakuła A, Oliva T, Sousa T, Fernandes PC, Tylki-Szymańska A, Kamenets E, Martins E and Socha P: Early onset lysosomal acid lipase deficiency presenting as secondary hemophagocytic lymphohistiocytosis: Two infants treated with sebelipase alfa. Clin Res Hepatol Gastroenterol. 42:e77–e82. 2018.PubMed/NCBI View Article : Google Scholar | |
Faraguna MC, Musto F, Crescitelli V, Iascone M, Spaccini L, Tonduti D, Fedeli T, Kullmann G, Canonico F, Cattoni A, et al: Mucopolysaccharidosis-plus syndrome, a rapidly progressive disease: Favorable impact of a very prolonged steroid treatment on the clinical course in a child. Genes (Basel). 13(442)2022.PubMed/NCBI View Article : Google Scholar | |
Merli P, Quintarelli C, Strocchio L and Locatelli F: The role of interferon-gamma and its signaling pathway in pediatric hematological disorders. Pediatr Blood Cancer. 68(e28900)2021.PubMed/NCBI View Article : Google Scholar | |
George MR: Hemophagocytic lymphohistiocytosis: Review of etiologies and management. J Blood Med. 5:69–86. 2014.PubMed/NCBI View Article : Google Scholar | |
Henter JI, Samuelsson-Horne A, Aricò M, Egeler RM, Elinder G, Filipovich AH, Gadner H, Imashuku S, Komp D, Ladisch S, et al: Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation. Blood. 100:2367–2373. 2002.PubMed/NCBI View Article : Google Scholar | |
Jordan M, Prof FL, Allen C, De Benedetti F, Grom AA, Ballabio M, Ferlin WG and De Min C: A novel targeted approach to the treatment of hemophagocytic lymphohistiocytosis (HLH) with an anti-interferon gamma (IFNγ) monoclonal antibody (mAb), NI-0501: First results from a pilot phase 2 study in children with primary HLH. Blood. 126:LBA–3. 2015. | |
Locatelli F, Jordan MB, Allen C, Cesaro S, Rizzari C, Rao A, Degar B, Garrington TP, Sevilla J, Putti MC, et al: Emapalumab in children with primary hemophagocytic lymphohistiocytosis. N Engl J Med. 382:1811–1822. 2020.PubMed/NCBI View Article : Google Scholar | |
Marsh RA, Allen CE, McClain KL, Weinstein JL, Kanter J, Skiles J, Lee ND, Khan SP, Lawrence J, Mo JQ, et al: Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab. Pediatr Blood Cancer. 60:101–109. 2013.PubMed/NCBI View Article : Google Scholar | |
Das R, Guan P, Sprague L, Verbist K, Tedrick P, An QA, Cheng C, Kurachi M, Levine R, Wherry EJ, et al: Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis. Blood. 127:1666–1675. 2016.PubMed/NCBI View Article : Google Scholar | |
De Benedetti F, Brunner HI, Ruperto N, Kenwright A, Wright S, Calvo I, Cuttica R, Ravelli A, Schneider R, Woo P, et al: Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis. N Engl J Med. 367:2385–2395. 2012.PubMed/NCBI View Article : Google Scholar | |
Huang P, Huang C, Xu H, Lu J, Tian R, Wang Z and Chen Y: Early use of blood purification in severe Epstein-Barr virus-associated hemophagocytic syndrome. Pediatrics. 145(e20193197)2020.PubMed/NCBI View Article : Google Scholar | |
Bottari G, Murciano M, Merli P, Bracaglia C, Guzzo I, Stoppa F, Pardeo M, Nunziata J, Bufalo FD, Genuini L, et al: Hemoperfusion with cytosorb to manage multiorgan dysfunction in the spectrum of hemophagocytic lymphohistiocytosis syndrome in critically Ill children. Blood Purif. 51:417–424. 2022.PubMed/NCBI View Article : Google Scholar | |
Matsumoto Y, Naniwa D, Banno S and Sugiura Y: The efficacy of therapeutic plasmapheresis for the treatment of fatal hemophagocytic syndrome: Two case reports. Ther Apher. 2:300–304. 1998.PubMed/NCBI View Article : Google Scholar | |
Demirkol D, Yildizdas D, Bayrakci B, Karapinar B, Kendirli T, Koroglu TF, Dursun O, Erkek N, Gedik H, Citak A, et al: Hyperferritinemia in the critically ill child with secondary hemophagocytic lymphohistiocytosis/sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome: What is the treatment? Crit Care. 16(R52)2012.PubMed/NCBI View Article : Google Scholar | |
La Rosée P, Horne A, Hines M, von Bahr Greenwood T, Machowicz R, Berliner N, Birndt S, Gil-Herrera J, Girschikofsky M, Jordan MB, et al: Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. Blood. 133:2465–2477. 2019.PubMed/NCBI View Article : Google Scholar | |
Yan WL, Yang SL, Zhao FY and Xu XJ: Ruxolitinib is an alternative to etoposide for patient with hemophagocytic lymphohistiocytosis complicated by acute renal injury: A case report. J Oncol Pharm Pract. 28:222–227. 2022.PubMed/NCBI View Article : Google Scholar | |
Broglie L, Pommert L, Rao S, Thakar M, Phelan R, Margolis D and Talano J: Ruxolitinib for treatment of refractory hemophagocytic lymphohistiocytosis. Blood Adv. 1:1533–1536. 2017.PubMed/NCBI View Article : Google Scholar | |
Cançado GGL, Freitas GG, Faria FHF, de Macedo AV and Nobre V: Hemophagocytic lymphohistiocytosis associated with visceral leishmaniasis in late adulthood. Am J Trop Med Hyg. 88:575–577. 2013.PubMed/NCBI View Article : Google Scholar | |
Imashuku S, Kuriyama K, Teramura T, Ishii E, Kinugawa N, Kato M, Sako M and Hibi S: Requirement for etoposide in the treatment of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. J Clin Oncol. 19:2665–2673. 2001.PubMed/NCBI View Article : Google Scholar | |
Huang Z and Xie J: Ruxolitinib in conjunction with the HLH-94 protocol for Epstein-Barr virus-related hemophagocytic lymphohistiocytosis in the intensive care unit: A case report. Medicine (Baltimore). 100(e25188)2021.PubMed/NCBI View Article : Google Scholar | |
Zhao Y, Li Z, Zhang L, Lian H, Ma H, Wang D, Zhao X, Zhang Q, Wang T and Zhang R: L-DEP regimen salvage therapy for paediatric patients with refractory Epstein-Barr virus-associated haemophagocytic lymphohistiocytosis. Br J Haematol. 191:453–459. 2020.PubMed/NCBI View Article : Google Scholar | |
Shiraishi A, Ohga S, Doi T, Ishimura M, Takimoto T, Takada H, Miyamoto T, Abe Y and Hara T: Treatment choice of immunotherapy or further chemotherapy for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 59:265–270. 2012.PubMed/NCBI View Article : Google Scholar | |
Lackner H, Seidel MG, Strenger V, Sovinz P, Schwinger W, Benesch M, Sperl D and Urban C: Hemophagocytic syndrome in children with acute monoblastic leukemia-another cause of fever of unknown origin. Support Care Cancer. 21:3519–3523. 2013.PubMed/NCBI View Article : Google Scholar | |
Chi MS, Chang YC and Chi KH: In reply to roos et al. Int J Radiat Oncol Biol Phys. 101(1003)2018. | |
Han L, Li L, Wu J, Li X, Zhang L, Wang X, Fu X, Ma W, Sun Z, Zhang X, et al: Clinical features and treatment of natural killer/T cell lymphoma associated with hemophagocytic syndrome: comparison with other T cell lymphoma associated with hemophagocytic syndrome. Leuk Lymphoma. 55:2048–2055. 2014.PubMed/NCBI View Article : Google Scholar | |
Eloseily EM, Weiser P, Crayne CB, Haines H, Mannion ML, Stoll ML, Beukelman T, Atkinson TP and Cron RQ: Benefit of anakinra in treating pediatric secondary hemophagocytic lymphohistiocytosis. Arthritis Rheumatol. 72:326–334. 2020.PubMed/NCBI View Article : Google Scholar | |
Bami S, Vagrecha A, Soberman D, Badawi M, Cannone D, Lipton JM, Cron RQ and Levy CF: The use of anakinra in the treatment of secondary hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 67(e28581)2020.PubMed/NCBI View Article : Google Scholar | |
Bagri NK, Gupta L, Sen ES and Ramanan AV: Macrophage activation syndrome in children: Diagnosis and management. Indian Pediatr. 58:1155–1161. 2021.PubMed/NCBI View Article : Google Scholar | |
Ravelli A, Minoia F, Davì S, Horne A, Bovis F, Pistorio A, Aricò M, Avcin T, Behrens EM, De Benedetti F, et al: 2016 Classification criteria for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: A European league against rheumatism/American college of rheumatology/paediatric rheumatology international trials organisation collaborative initiative. Arthritis Rheumatol. 68:566–576. 2016.PubMed/NCBI View Article : Google Scholar | |
Shalabi H, Gust J, Taraseviciute A, Wolters PL, Leahy AB, Sandi C, Laetsch TW, Wiener L, Gardner RA, Nussenblatt V, et al: Beyond the storm-subacute toxicities and late effects in children receiving CAR T cells. Nat Rev Clin Oncol. 18:363–378. 2021.PubMed/NCBI View Article : Google Scholar | |
Ishida H, Yoshida H, Yoshihara T, Ito M and Morimoto A: Origin of macrophages involved in the development of allogeneic hematopoietic stem cell transplantation-associated hemophagocytic syndrome: Observations on a patient with juvenile myelomonocytic leukemia. Bone Marrow Transplant. 40:701–703. 2007.PubMed/NCBI View Article : Google Scholar | |
Ostronoff M, Ostronoff F, Coutinho M, Calixto R, Souto Maior AP, Sucupira A, Florencio R and Tagliari C: Hemophagocytic syndrome after autologous peripheral blood stem cell transplantation for multiple myeloma; successful treatment with high-dose intravenous immunoglobulin. Bone Marrow Transplant. 37:797–798. 2006.PubMed/NCBI View Article : Google Scholar | |
Koyama M, Sawada A, Yasui M, Inoue M and Kawa K: Encouraging results of low-dose etoposide in the treatment of early-onset hemophagocytic syndrome following allogeneic hematopoietic stem cell transplantation. Int J Hematol. 86:466–467. 2007.PubMed/NCBI View Article : Google Scholar | |
Ono R, Ashiarai M, Hirabayashi S, Mizuki K, Hosoya Y, Yoshihara H, Ohtake J, Mori S, Manabe A and Hasegawa D: Ruxolitinib for hematopoietic cell transplantation-associated hemophagocytic lymphohistiocytosis. Int J Hematol. 113:297–301. 2021.PubMed/NCBI View Article : Google Scholar | |
Janka GE: Familial hemophagocytic lymphohistiocytosis. Eur J Pediatr. 140:221–230. 1983.PubMed/NCBI View Article : Google Scholar | |
Messina C, Zecca M, Fagioli F, Rovelli A, Giardino S, Merli P, Porta F, Aricò M, Sieni E, Basso G, et al: Outcomes of children with hemophagocytic lymphohistiocytosis given allogeneic hematopoietic stem cell transplantation in italy. Biol Blood Marrow Transplant. 24:1223–1231. 2018.PubMed/NCBI View Article : Google Scholar |