Open Access

Secondary hemophagocytic lymphohistiocytosis in children (Review)

  • This article is part of the special Issue: Hemophagocytic lymphohistiocytosis
  • Authors:
    • Chiara Benevenuta
    • Ilaria Mussinatto
    • Cecilia Orsi
    • Fabio S. Timeus
  • View Affiliations

  • Published online on: July 17, 2023     https://doi.org/10.3892/etm.2023.12122
  • Article Number: 423
  • Copyright: © Benevenuta et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare, life‑threatening condition characterized by hyperinflammation in an uncontrolled and ineffective immune response. Despite great improvement in diagnosis and treatment, it still represents a challenge in clinical management, with poor prognosis in the absence of an aggressive therapeutic approach. The present literature review focuses on secondary HLH at pediatric age, which represents a heterogeneous group in terms of etiology and therapeutic approach. It summarizes the most recent evidence on epidemiology, pathophysiology, diagnosis, treatment and prognosis, and provides a detailed description and comparison of the major subtypes of secondary HLH. Finally, it addresses the open questions with a focus on diagnosis and new treatment insights.
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September-2023
Volume 26 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Benevenuta C, Mussinatto I, Orsi C and Timeus FS: Secondary hemophagocytic lymphohistiocytosis in children (Review). Exp Ther Med 26: 423, 2023.
APA
Benevenuta, C., Mussinatto, I., Orsi, C., & Timeus, F.S. (2023). Secondary hemophagocytic lymphohistiocytosis in children (Review). Experimental and Therapeutic Medicine, 26, 423. https://doi.org/10.3892/etm.2023.12122
MLA
Benevenuta, C., Mussinatto, I., Orsi, C., Timeus, F. S."Secondary hemophagocytic lymphohistiocytosis in children (Review)". Experimental and Therapeutic Medicine 26.3 (2023): 423.
Chicago
Benevenuta, C., Mussinatto, I., Orsi, C., Timeus, F. S."Secondary hemophagocytic lymphohistiocytosis in children (Review)". Experimental and Therapeutic Medicine 26, no. 3 (2023): 423. https://doi.org/10.3892/etm.2023.12122