Growth differentiation factor‑15 in patients with gestational diabetes mellitus and its relationship with microalbuminuria

  • Authors:
    • Yinyun Gong
    • Jin Shi
    • Jing Li
    • Lan Liu
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  • Published online on: July 19, 2023     https://doi.org/10.3892/etm.2023.12126
  • Article Number: 427
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Abstract

Gestational diabetes mellitus (GDM) is a common pregnancy‑related complication and growth differentiation factor‑15 (GDF‑15) is involved in a number of diseases; therefore, the aim of the present study was to investigate the level and clinical significance of serum GDF‑15 levels in patients with GDM. A total of 237 pregnant women at 20‑24 weeks of gestation were selected and assigned to a normal pregnancy group (70 patients) and a GDM group (167 patients) according to the presence or absence of GDM. The general clinical data of the two groups were collected. Fasting plasma glucose, 1‑h plasma glucose, 2‑h plasma glucose, glycated hemoglobin, fasting insulin, 24‑h urinary albumin and serum GDF‑15 levels were measured. The results showed that the body mass index (BMI) of the GDM group was higher than that of the normal pregnancy group. Fasting plasma glucose, 1‑h plasma glucose, 2‑h plasma glucose, fasting insulin, glycated hemoglobin and GDF‑15 levels and the positive rate of microalbuminuria were significantly higher in the GDM group compared with the normal pregnancy group. GDF‑15 levels were positively correlated with BMI, fasting plasma glucose, glycated hemoglobin, homeostasis model assessment‑insulin resistance and fasting insulin levels. Logistic regression analysis suggested that elevated GDF‑15 levels are an independent risk factor for microalbuminuria. In conclusion, serum GDF‑15 levels are strongly associated with GDM and elevated GDF‑15 levels are an independent risk factor for microalbuminuria. Serum GDF‑15 may act as a novel biomarker for predicting microalbuminuria in GDM patients.
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September-2023
Volume 26 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Gong Y, Shi J, Li J and Liu L: Growth differentiation factor‑15 in patients with gestational diabetes mellitus and its relationship with microalbuminuria. Exp Ther Med 26: 427, 2023
APA
Gong, Y., Shi, J., Li, J., & Liu, L. (2023). Growth differentiation factor‑15 in patients with gestational diabetes mellitus and its relationship with microalbuminuria. Experimental and Therapeutic Medicine, 26, 427. https://doi.org/10.3892/etm.2023.12126
MLA
Gong, Y., Shi, J., Li, J., Liu, L."Growth differentiation factor‑15 in patients with gestational diabetes mellitus and its relationship with microalbuminuria". Experimental and Therapeutic Medicine 26.3 (2023): 427.
Chicago
Gong, Y., Shi, J., Li, J., Liu, L."Growth differentiation factor‑15 in patients with gestational diabetes mellitus and its relationship with microalbuminuria". Experimental and Therapeutic Medicine 26, no. 3 (2023): 427. https://doi.org/10.3892/etm.2023.12126