Open Access

Long non‑coding RNAs, lipid metabolism and cancer (Review)

  • Authors:
    • Zhen-Dong Zhang
    • Xin-Rui Hou
    • Xiao-Lan Cao
    • Xiao-Ping Wang
  • View Affiliations

  • Published online on: August 17, 2023     https://doi.org/10.3892/etm.2023.12169
  • Article Number: 470
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer has emerged as the most common cause of death in China. The change in lipid metabolism has been confirmed to have a role in several tumor types, such as esophageal, gastric, colorectal and liver cancer. Cancer cells use lipid metabolism for energy and then rapidly proliferate, invade and migrate. The main pathway by which cancer cell lipid metabolism influences cancer progression is increased fatty acid synthesis. Long non‑coding (lnc)RNAs are important ncRNAs that were indicated to have significant roles in the development of human tumors. They are considered potential tumor biomarkers. Increased lipid synthesis or uptake due to deregulation of lncRNAs contributes to rapid tumor growth. In the present review, current studies on the relationship between lncRNAs, lipid metabolism and the occurrence and development of tumors were collated and summarized, and their mechanism of action was discussed. The review is expected to provide a theoretical basis for tumor treatment and prognosis evaluation based on the effective regulation of lncRNAs and lipid metabolism.
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October-2023
Volume 26 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang Z, Hou X, Cao X and Wang X: Long non‑coding RNAs, lipid metabolism and cancer (Review). Exp Ther Med 26: 470, 2023
APA
Zhang, Z., Hou, X., Cao, X., & Wang, X. (2023). Long non‑coding RNAs, lipid metabolism and cancer (Review). Experimental and Therapeutic Medicine, 26, 470. https://doi.org/10.3892/etm.2023.12169
MLA
Zhang, Z., Hou, X., Cao, X., Wang, X."Long non‑coding RNAs, lipid metabolism and cancer (Review)". Experimental and Therapeutic Medicine 26.4 (2023): 470.
Chicago
Zhang, Z., Hou, X., Cao, X., Wang, X."Long non‑coding RNAs, lipid metabolism and cancer (Review)". Experimental and Therapeutic Medicine 26, no. 4 (2023): 470. https://doi.org/10.3892/etm.2023.12169