Altered brain network centrality in patients with orbital fracture: A resting‑state functional MRI study

Liu,Yinuo; Gao,Yuxuan; Shu,Huiye; Li,Qiuyu; Ge,Qianmin; Liao,Xulin; Pan,Yicong; Wu,Jieli; Su,Ting; Zhang,Lijuan; Liang,Rongbin; Shao,Yi

doi:10.3892/etm.2023.12251

Altered brain network centrality in patients with orbital fracture: A resting‑state functional MRI study

Authors:
- Yinuo Liu
- Yuxuan Gao
- Huiye Shu
- Qiuyu Li
- Qianmin Ge
- Xulin Liao
- Yicong Pan
- Jieli Wu
- Ting Su
- Lijuan Zhang
- Rongbin Liang
- Yi Shao
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Affiliations: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of National Clinical Ophthalmology Institute, Nanchang, Jiangxi 330006, P.R. China, Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of National Clinical Ophthalmology Institute, Nanchang, Jiangxi 330006, P.R. China, Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong 999077, P.R. China, Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute of Xiamen University, Xiamen University School of Medicine, Xiamen, Fujian 361102, P.R. China
Published online on: October 17, 2023 https://doi.org/10.3892/etm.2023.12251
Article Number: 552
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate potential functional network brain‑activity abnormalities in individuals with orbital fracture (OF) using the voxel‑wise degree centrality (DC) technique. The present study included 20 patients with OF (12 males and 8 females) and 20 healthy controls (HC; 12 males and 8 females), who were matched for gender, age and educational attainment. Functional magnetic resonance imaging (fMRI) in the resting state has been widely applied in several fields. Receiver operating characteristic (ROC) curves were calculated to distinguish between patients with OF and HCs. In addition, correlation analyses were performed between behavioral performance and average DC values in various locations. The DC technique was used to assess unprompted brain activity. Right cerebellum 9 region (Cerebelum_9_R) and left cerebellar peduncle 2 area (Cerebelum_Crus2_L) DC values of patients with OF were increased compared with those in HCs. Cerebelum_9_R and Cerebelum_Crus2_L had area under the ROC curve values of 0.983 and 1.000, respectively. Patients with OF appear to have several brain regions that exhibited aberrant brain network characteristics, which raises the possibility of neuropathic causes and offers novel therapeutic options.

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