Open Access

Carbon dioxide laser therapy for the management of genitourinary syndrome of menopause: A meta‑analysis of randomized controlled trials

  • Authors:
    • Yihua Ni
    • Junyu Lian
  • View Affiliations

  • Published online on: November 13, 2023     https://doi.org/10.3892/etm.2023.12297
  • Article Number: 10
  • Copyright : © Ni et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Genitourinary symptoms of menopause (GSM) affect ~50% of women after menopause. Recently, CO2 laser therapy has been used for managing GSM but without high quality evidence. The present review assessed the effectiveness of CO2 laser therapy in the management of GSM. PubMed, Embase, Web of Science, CENTRAL and Scopus databases were searched for randomized controlled trials (RCTs), published up to June 30, 2023, comparing CO2 laser and sham laser treatments for GSM management. The outcomes of interest included Female Sexual Function Index (FSFI), Vaginal Health Index (VHI) and visual analog scale (VAS) for dyspareunia, dryness, burning, itching and dysuria. A total of seven RCTs were included in the review and meta‑analysis, with 6/7 studies using three sessions of laser therapy, 4‑8 weeks apart. Meta‑analysis demonstrated no statistically significant difference in FSFI [mean difference (MD), ‑1.48; 95% CI, ‑5.85, 2.89; I2=45%] and VHI scores (MD, ‑0.18; 95% CI, ‑1.66, 1.31; I2 =72%) between laser and control groups. Meta‑analysis also demonstrated no statistically significant difference in VAS scores for dyspareunia (MD, ‑1.63; 95% CI; ‑4.06, 0.80; I2=91%), dryness (MD, ‑1.30; 95% CI, ‑3.14, 0.53; I2=75%), burning (MD, ‑0.76; 95% CI, ‑2.03; 0.51 I2=56%), itching (MD, ‑0.28; 95% CI, ‑0.95, 0.38; I2=0%) and dysuria (MD, 0.15; 95% CI, ‑0.37, 0.67; I2=23%) between the groups. The included RCTs had low risk of bias. In conclusion, meta‑analyses of high‑quality sham‑controlled RCTs indicated that CO2 may not have any beneficial effect on GSM. Limited data and high heterogeneity in meta‑analyses in this area of research are important limitations that need to be addressed by future RCTs.
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Spandidos Publications style
Ni Y and Lian J: Carbon dioxide laser therapy for the management of genitourinary syndrome of menopause: A meta‑analysis of randomized controlled trials. Exp Ther Med 27: 10, 2024.
APA
Ni, Y., & Lian, J. (2024). Carbon dioxide laser therapy for the management of genitourinary syndrome of menopause: A meta‑analysis of randomized controlled trials. Experimental and Therapeutic Medicine, 27, 10. https://doi.org/10.3892/etm.2023.12297
MLA
Ni, Y., Lian, J."Carbon dioxide laser therapy for the management of genitourinary syndrome of menopause: A meta‑analysis of randomized controlled trials". Experimental and Therapeutic Medicine 27.1 (2024): 10.
Chicago
Ni, Y., Lian, J."Carbon dioxide laser therapy for the management of genitourinary syndrome of menopause: A meta‑analysis of randomized controlled trials". Experimental and Therapeutic Medicine 27, no. 1 (2024): 10. https://doi.org/10.3892/etm.2023.12297