Exposure factors in the occurrence and development of melasma (Review)
- This article is part of the special Issue: Immuno-Dermatology
- Authors:
- Yijun Chen
- Gautham Vellaichamy
- Samantha L. Schneider
- Wei Kong
- Zhichao Liu
-
Affiliations: Department of Dermatology, The Secondary Affiliated Hospital, Shandong First Medical University, Tai'an, Shandong 271000, P.R. China, Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health System, Detroit, MI 48201, USA - Published online on: February 6, 2024 https://doi.org/10.3892/etm.2024.12419
- Article Number: 131
This article is mentioned in:
Abstract
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Negbenebor NA, Heath CR and Usatine RP: Melasma. J Fam Pract. 72:133–137. 2023.PubMed/NCBI View Article : Google Scholar | |
de Abreu L, Ramos-E-Silva M, Quintella LP, Buçard AM, Bravo BSF, de Almeida AM and Moreira ACMS: Dermoscopic classification of melasma: Concordance study and correlation with the melanophages count. J Cosmet Dermatol. 21:5887–5894. 2022.PubMed/NCBI View Article : Google Scholar | |
Khunger N, Kandhari R, Singh A and Ramesh V: A clinical, dermoscopic, histopathological and immunohistochemical study of melasma and facial pigmentary demarcation lines in the skin of color. Dermatol Ther. 33(e14515)2020.PubMed/NCBI View Article : Google Scholar | |
Goandal NF, Rungby J and Karmisholt KE: The role of sex hormones in the pathogenesis of melasma. Ugeskr Laeger. 184(V10210769)2022.PubMed/NCBI(In Danish). | |
Zhou Y, Zeng HL, Wen XY, Jiang L, Fu CH, Hu YB, Lei XX, Zhang L, Yu X, Yang SY, et al: Selaginellin inhibits melanogenesis via the MAPK signaling pathway. J Nat Prod. 85:838–845. 2022.PubMed/NCBI View Article : Google Scholar | |
Filoni A, Mariano M and Cameli N: Melasma: How hormones can modulate skin pigmentation. J Cosmet Dermatol. 18:458–463. 2019.PubMed/NCBI View Article : Google Scholar | |
Sarkar R, Ailawadi P and Garg S: Melasma in Men: A review of clinical, etiological, and management issues. J Clin Aesthet Dermatol. 11:53–59. 2018.PubMed/NCBI | |
Sarkar R, Jagadeesan S, Basavapura Madegowda S, Verma S, Hassan I, Bhat Y, Minni K, Jha A, Das A, Jain G, et al: Clinical and epidemiologic features of melasma: A multicentric cross-sectional study from India. Int J Dermatol. 58:1305–1310. 2019.PubMed/NCBI View Article : Google Scholar | |
Kheradmand M, Afshari M, Damiani G, Abediankenari S and Moosazadeh M: Melasma and thyroid disorders: A systematic review and meta-analysis. Int J Dermatol. 58:1231–1238. 2019.PubMed/NCBI View Article : Google Scholar | |
Rostami Mogaddam M, Safavi Ardabili N, Iranparvar Alamdari M, Maleki N and Aghabalaei Danesh M: Evaluation of the serum zinc level in adult patients with melasma: Is there a relationship with serum zinc deficiency and melasma? J Cosmet Dermatol. 17:417–422. 2018.PubMed/NCBI View Article : Google Scholar | |
Nelson B, Sitohang IBS, Marissa M, Indriatmi W and Wisnu W: A comparative study of melasma severity after hyperthyroid therapy in hyperthyroid subjects with melasma. Acta Dermatovenerol Alp Pannonica Adriat. 30:31–34. 2021.PubMed/NCBI | |
Sastrini Sekarnesia I, Sitohang IBS, Agustin T, Wisnu W and Hoemardani ASD: A comparison of serum zinc levels in melasma and non-melasma patients: A preliminary study of thyroid dysfunction. Acta Dermatovenerol Alp Pannonica Adriat. 29:59–62. 2020.PubMed/NCBI | |
Ghassemi M, Hosseinchi S, Seirafianpour F, Dodangeh M and Goodarzi A: Non-alcoholic fatty liver and lipid profile status in patients with melasma: A case-control study. J Cosmet Dermatol. 20:3656–3660. 2021.PubMed/NCBI View Article : Google Scholar | |
Nie Y and Jiang R: . The Effect of ShuganJieyu Formula on Treating Female Melasma and Its Influence on Sexual Hormone Levels. Journal of Dermatology and Venereology. 42:249–251. 2020. | |
Yu T, Feng Y, Yu H, et al: Therapeutic Efficacy and Safety of Compound Muni Ziqi Granules in the Adjuvant Treatment of Chloasma: A Systematic Review. J China Pharmacy. 29:405–409. 2018. | |
Kwon SH, Na JI, Choi JY and Park KC: Melasma: Updates and perspectives. Exp Dermatol. 28:704–708. 2019.PubMed/NCBI View Article : Google Scholar | |
Fatima S, Braunberger T, Mohammad TF, Kohli I and Hamzavi IH: The role of sunscreen in melasma and postinflammatory hyperpigmentation. Indian J Dermatol. 65:5–10. 2020.PubMed/NCBI View Article : Google Scholar | |
Eide MJ and Weinstock MA: Association of UV index, latitude, and melanoma incidence in nonwhite populations-US Surveillance, Epidemiology, and End Results (SEER) Program, 1992 to 2001. Arch Dermatol. 141:477–481. 2005.PubMed/NCBI View Article : Google Scholar | |
Singh G, Chatterjee M, Grewal R and Verma R: Incidence and care of environmental dermatoses in the high-altitude region of ladakh, India. Indian J Dermatol. 58:107–112. 2013.PubMed/NCBI View Article : Google Scholar | |
Passeron T and Picardo M: Melasma, a photoaging disorder. Pigment Cell Melanoma Res. 31:461–465. 2018.PubMed/NCBI View Article : Google Scholar | |
Herraiz C, Garcia-Borron JC, Jiménez-Cervantes C and Olivares C: MC1R signaling. Intracellular partners and pathophysiological implications. Biochim Biophys Acta Mol Basis Dis. 1863 (10 Pt A):2448–2461. 2017.PubMed/NCBI View Article : Google Scholar | |
Kim M, Shibata T, Kwon S, Park TJ and Kang HY: Ultraviolet-irradiated endothelial cells secrete stem cell factor and induce epidermal pigmentation. Sci Rep. 8(4235)2018.PubMed/NCBI View Article : Google Scholar | |
Seo EY, Jin SP, Sohn KC, Park CH, Lee DH and Chung JH: UCHL1 regulates melanogenesis through controlling MITF stability in human melanocytes. J Invest Dermatol. 137:1757–1765. 2017.PubMed/NCBI View Article : Google Scholar | |
Xing X, Xu Z, Chen L, Jin S, Zhang C and Xiang L: Tranexamic acid inhibits melanogenesis partially via stimulation of TGF-β1 expression in human epidermal keratinocytes. Exp Dermatol. 31:633–640. 2022.PubMed/NCBI View Article : Google Scholar | |
Kumaran MS, Narayan RV, Kaushik A, Bishnoi A, Vinay K and Parsad D: Clinico-epidemiological profile and long term follow up in melasma. Dermatol Ther. 34(e15143)2021.PubMed/NCBI View Article : Google Scholar | |
Holmo NF, Ramos GB, Salomão H, Werneck RI, Mira MT, Miot LDB and Miot HA: Complex segregation analysis of facial melasma in Brazil: Evidence for a genetic susceptibility with a dominant pattern of segregation. Arch Dermatol Res. 310:827–831. 2018.PubMed/NCBI View Article : Google Scholar | |
Desai S, Ayres E, Bak H, Manco M, Lynch S, Raab S, Du A, Green D, Skobowiat C, Wangari-Talbot J and Zheng Q: Effect of a tranexamic acid, kojic acid, and niacinamide containing serum on facial dyschromia: A clinical evaluation. J Drugs Dermatol. 18:454–459. 2019.PubMed/NCBI | |
Suryaningsih BE, Sadewa AH, Wirohadidjojo YW and Soebono H: Association between heterozygote Val92Met MC1R gene polymorphisms with incidence of melasma: A study of Javanese women population in Yogyakarta. Clin Cosmet Investig Dermatol. 12:489–495. 2019.PubMed/NCBI View Article : Google Scholar | |
Handa S, De D, Khullar G, Radotra BD and Sachdeva N: The clinicoaetiological, hormonal and histopathological characteristics of melasma in men. Clin Exp Dermatol. 43:36–41. 2018.PubMed/NCBI View Article : Google Scholar | |
Sun M, Xie HF, Tang Y, Lin SQ, Li JM, Sun SN, Hu XL, Huang YX, Shi W and Jian D: G protein-coupled estrogen receptor enhances melanogenesis via cAMP-protein kinase (PKA) by upregulating microphthalmia-related transcription factor-tyrosinase in melanoma. J Steroid Biochem Mol Biol. 165(Pt B):236–246. 2017.PubMed/NCBI View Article : Google Scholar | |
Campuzano-García AE, Torres-Alvarez B, Hernández-Blanco D, Fuentes-Ahumada C, Cortés-García JD and Castanedo-Cázares JP: DNA methyltransferases in malar melasma and their modification by sunscreen in combination with 4% Niacinamide, 0.05% Retinoic Acid, or Placebo. Biomed Res Int. 2019(9068314)2019.PubMed/NCBI View Article : Google Scholar | |
Kim NH, Choi SH, Kim CH, Lee CH, Lee TR and Lee AY: Reduced MiR-675 in exosome in H19 RNA-related melanogenesis via MITF as a direct target. J Invest Dermatol. 134:1075–1082. 2014.PubMed/NCBI View Article : Google Scholar | |
Kim JY, Lee TR and Lee AY: Reduced WIF-1 expression stimulates skin hyperpigmentation in patients with melasma. J Invest Dermatol. 133:191–200. 2013.PubMed/NCBI View Article : Google Scholar | |
Kim NH, Choi SH, Yi N, Lee TR and Lee AY: Arginase-2, a miR-1299 target, enhances pigmentation in melasma by reducing melanosome degradation via senescence-induced autophagy inhibition. Pigment Cell Melanoma Res. 30:521–530. 2017.PubMed/NCBI View Article : Google Scholar | |
Karami Fath M, Azami J, Masoudi A, Mosaddeghi Heris R, Rahmani E, Alavi F, Alagheband Bahrami A, Payandeh Z, Khalesi B, Dadkhah M, et al: Exosome-based strategies for diagnosis and therapy of glioma cancer. Cancer Cell Int. 22(262)2022.PubMed/NCBI View Article : Google Scholar | |
Kohli I, Chaowattanapanit S, Mohammad TF, Nicholson CL, Fatima S, Jacobsen G, Kollias N, Lim HW and Hamzavi IH: Synergistic effects of long-wavelength ultraviolet A1 and visible light on pigmentation and erythema. Br J Dermatol. 178:1173–1180. 2018.PubMed/NCBI View Article : Google Scholar | |
Lim HW, Kohli I, Ruvolo E, Kolbe L and Hamzavi IH: Impact of visible light on skin health: The role of antioxidants and free radical quenchers in skin protection. J Am Acad Dermatol. 86 (3S):S27–S37. 2022.PubMed/NCBI View Article : Google Scholar | |
Babbush KM, Babbush RA and Khachemoune A: The therapeutic use of antioxidants for melasma. J Drugs Dermatol. 19:788–792. 2020.PubMed/NCBI View Article : Google Scholar | |
Handel AC, Miot LD and Miot HA: Melasma: A clinical and epidemiological review. An Bras Dermatol. 89:771–782. 2014.PubMed/NCBI View Article : Google Scholar | |
Katiyar S and Yadav D: Correlation of oxidative stress with melasma: An overview. Curr Pharm Des. 28:225–231. 2022.PubMed/NCBI View Article : Google Scholar | |
Ogbechie-Godec OA and Elbuluk N: Melasma: An up-to-date comprehensive review. Dermatol Ther (Heidelb). 7:305–318. 2017.PubMed/NCBI View Article : Google Scholar | |
Chun L: Clinical efficacy of glutathione combined with vitamin C in the treatment of female chloasma and its effect on estrogen and progesterone levels. J Contemporary Medicine. 28:60–62. 2022. | |
Hu Y, Wang P and Han K: Hydrogen attenuated inflammation response and oxidative in hypoxic ischemic encephalopathy via Nrf2 mediated the inhibition of NLRP3 and NF-κB. Neuroscience. 485:23–36. 2022.PubMed/NCBI View Article : Google Scholar | |
Zhu Q, Wu Y, Li Y, Chen Z, Wang L, Xiong H, Dai E, Wu J, Fan B, Ping L and Luo X: Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. Sci Rep. 8(8051)2018.PubMed/NCBI View Article : Google Scholar | |
Chilicka K, Rogowska AM and Szyguła R: Effects of topical hydrogen purification on skin parameters and acne vulgaris in adult women. Healthcare (Basel). 9(144)2021.PubMed/NCBI View Article : Google Scholar | |
Yoon YS, Sajo ME, Ignacio RM, Kim SK, Kim CS and Lee KJ: Positive Effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice. Biol Pharm Bull. 37:1480–1485. 2014.PubMed/NCBI View Article : Google Scholar | |
He L: New ideas for the diagnosis and treatment of melasma. J Dermatology and Venereology. 34:13–14. 2012. | |
Flori E, Mastrofrancesco A, Mosca S, Ottaviani M, Briganti S, Cardinali G, Filoni A, Cameli N, Zaccarini M, Zouboulis CC and Picardo M: Sebocytes contribute to melasma onset. iScience. 25(103871)2022.PubMed/NCBI View Article : Google Scholar | |
Kim M, Lee J, Park TJ and Kang HY: Paracrine crosstalk between endothelial cells and melanocytes through clusterin to inhibit pigmentation. Exp Dermatol. 27:98–100. 2018.PubMed/NCBI View Article : Google Scholar | |
Ayhan E: Intralesional tranexamic acid in treatment of telangiectasia: Reversible effect and resistance to therapy. Clin Exp Dermatol. 44:e209–e210. 2019.PubMed/NCBI View Article : Google Scholar | |
Geddes ER, Stout AB and Friedman PM: Retrospective analysis of the treatment of melasma lesions exhibiting increased vascularity with the 595-nm pulsed dye laser combined with the 1927-nm fractional low-powered diode laser. Lasers Surg Med. 49:20–26. 2017.PubMed/NCBI View Article : Google Scholar | |
Song T, Zhang X, Gao N, et al: Therapeutic efficacy of intense pulsed light combined with Nd: YAG laser for treatment of chloasma. Chinese Journal of Medical Physics. 38:1535–1537. 2021. | |
Espósito ACC, Brianezi G, de Souza NP, Miot LDB, Marques MEA and Miot HA: Exploring pathways for sustained melanogenesis in facial melasma: An immunofluorescence study. Int J Cosmet Sci. 40:420–424. 2018.PubMed/NCBI View Article : Google Scholar | |
Phansuk K, Vachiramon V, Jurairattanaporn N, Chanprapaph K and Rattananukrom T: Dermal pathology in melasma: An update review. Clin Cosmet Investig Dermatol. 15:11–19. 2022.PubMed/NCBI View Article : Google Scholar | |
Espósito ACC, Brianezi G, de Souza NP, Miot LDB and Miot HA: Exploratory study of epidermis, basement membrane zone, upper dermis alterations and wnt pathway activation in melasma compared to adjacent and retroauricular skin. Ann Dermatol. 32:101–108. 2020.PubMed/NCBI View Article : Google Scholar | |
Rodríguez-Arámbula A, Torres-Álvarez B, Cortés-García D, Fuentes-Ahumada C and Castanedo-Cázares JP: CD4, IL-17, and COX-2 Are associated with subclinical inflammation in malar melasma. Am J Dermatopathol. 37:761–766. 2015.PubMed/NCBI View Article : Google Scholar | |
Gautam M, Patil S, Nadkarni N, Sandhu M, Godse K and Setia M: Histopathological comparison of lesional and perilesional skin in melasma: A cross-sectional analysis. Indian J Dermatol Venereol Leprol. 85:367–373. 2019.PubMed/NCBI View Article : Google Scholar | |
Li Y, Yang CY, Man MQ, Gu H, Wu WJ, Tu Y, Ding DM and He L: Disruption of epidermal permeability barrier enhances UV-induced hyperpigmentation. Photodermatol Photoimmunol Photomed. 36:156–158. 2020.PubMed/NCBI View Article : Google Scholar | |
Sohn E: Skin microbiota's community effort. Nature. 563:S91–S93. 2018.PubMed/NCBI View Article : Google Scholar | |
Yan S: Skin Barrier and Melasma. Dermatology Bulletin. 39:430–434. 2022. | |
Nofal A, Ibrahim AM, Nofal E, Gamal N and Osman S: Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study. J Cosmet Dermatol. 18:263–270. 2019.PubMed/NCBI View Article : Google Scholar | |
Zou P, Du Y, Yang C and Cao Y: Trace element zinc and skin disorders. Front Med (Lausanne). 9(1093868)2022.PubMed/NCBI View Article : Google Scholar |