Open Access

Modulation of secretory factors by lipofundin contributes to its anti‑neuroinflammatory effects

  • Authors:
    • Ming-Shan Chen
    • Chia-Lin Hu
    • Shin-Kuang Jiang
    • Zhi-Yong Chong
    • Jui-Chieh Chen
  • View Affiliations

  • Published online on: February 27, 2024     https://doi.org/10.3892/etm.2024.12456
  • Article Number: 169
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

As the global population ages, the prevalence of neuroinflammatory diseases such as Alzheimer's disease, Parkinson's disease and stroke continues to increase. Therefore, it is necessary to develop preventive and therapeutic methods against neuroinflammatory diseases. Lipofundin is a lipid emulsion commonly used in clinical anesthetic solvents and nutritional supplements. Lipid emulsions have been shown to possess anti‑inflammatory properties. However, the potential beneficial effect of lipofundin against neuroinflammation requires elucidation. In the present study, two cell models were used to investigate the efficacy of lipofundin against neuroinflammation. In the first model, BV2 mouse microglial cells were treated with lipopolysaccharide (LPS) to induce nitric oxide (NO) production as a model of neuroinflammation. In the second model, HMC3 human microglial were activated by LPS, and changes in the secretion of factors associated with inflammation were analyzed using Luminex xMAP® technology. Griess assay results revealed that lipofundin significantly prevented and treated LPS‑induced NO production. An anti‑neuroinflammatory effect was also observed in HMC3 cells, where lipofundin exhibited excellent preventive and therapeutic properties by reducing the LPS‑induced expression and secretion of interleukin‑1β. Notably, lipofundin also promoted the secretion of certain growth factors, suggesting a potential neuroprotective effect. These results demonstrate that, in addition to its role as a solvent for drugs and nutritional support, lipofundin may also have beneficial effects in alleviating the progression of neuroinflammation. These findings may serve as an important reference for future translational medicine applications.
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April-2024
Volume 27 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Chen M, Hu C, Jiang S, Chong Z and Chen J: Modulation of secretory factors by lipofundin contributes to its anti‑neuroinflammatory effects. Exp Ther Med 27: 169, 2024.
APA
Chen, M., Hu, C., Jiang, S., Chong, Z., & Chen, J. (2024). Modulation of secretory factors by lipofundin contributes to its anti‑neuroinflammatory effects. Experimental and Therapeutic Medicine, 27, 169. https://doi.org/10.3892/etm.2024.12456
MLA
Chen, M., Hu, C., Jiang, S., Chong, Z., Chen, J."Modulation of secretory factors by lipofundin contributes to its anti‑neuroinflammatory effects". Experimental and Therapeutic Medicine 27.4 (2024): 169.
Chicago
Chen, M., Hu, C., Jiang, S., Chong, Z., Chen, J."Modulation of secretory factors by lipofundin contributes to its anti‑neuroinflammatory effects". Experimental and Therapeutic Medicine 27, no. 4 (2024): 169. https://doi.org/10.3892/etm.2024.12456