Open Access

Role of crosstalk between synovial cells and chondrocytes in osteoarthritis (Review)

  • Authors:
    • Baisen Chen
    • Yuyu Sun
    • Guanhua Xu
    • Jiawei Jiang
    • Wenhao Zhang
    • Chunshuai Wu
    • Pengfei Xue
    • Zhiming Cui
  • View Affiliations

  • Published online on: March 15, 2024     https://doi.org/10.3892/etm.2024.12490
  • Article Number: 201
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteoarthritis (OA) is a low‑grade, nonspecific inflammatory disease that affects the entire joint. This condition is characterized by synovitis, cartilage erosion, subchondral bone defects, and subpatellar fat pad damage. There is mounting evidence demonstrating the significance of crosstalk between synovitis and cartilage destruction in the development of OA. To comprehensively explore the phenotypic alterations of synovitis and cartilage destruction, it is important to elucidate the crosstalk mechanisms between chondrocytes and synovial cells. Furthermore, the updated iteration of single‑cell sequencing technology reveals the interaction between chondrocyte and synovial cells. In the present review, the histological and pathological alterations between cartilage and synovium during OA progression are described, and the mode of interaction and molecular mechanisms between synovial cells and chondrocytes in OA, both of which affect the OA process mainly by altering the inflammatory environment and cellular state, are elucidated. Finally, the current OA therapeutic approaches are summarized and emerging therapeutic targets are reviewed in an attempt to provide potential insights into OA treatment.
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May-2024
Volume 27 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Chen B, Sun Y, Xu G, Jiang J, Zhang W, Wu C, Xue P and Cui Z: Role of crosstalk between synovial cells and chondrocytes in osteoarthritis (Review). Exp Ther Med 27: 201, 2024.
APA
Chen, B., Sun, Y., Xu, G., Jiang, J., Zhang, W., Wu, C. ... Cui, Z. (2024). Role of crosstalk between synovial cells and chondrocytes in osteoarthritis (Review). Experimental and Therapeutic Medicine, 27, 201. https://doi.org/10.3892/etm.2024.12490
MLA
Chen, B., Sun, Y., Xu, G., Jiang, J., Zhang, W., Wu, C., Xue, P., Cui, Z."Role of crosstalk between synovial cells and chondrocytes in osteoarthritis (Review)". Experimental and Therapeutic Medicine 27.5 (2024): 201.
Chicago
Chen, B., Sun, Y., Xu, G., Jiang, J., Zhang, W., Wu, C., Xue, P., Cui, Z."Role of crosstalk between synovial cells and chondrocytes in osteoarthritis (Review)". Experimental and Therapeutic Medicine 27, no. 5 (2024): 201. https://doi.org/10.3892/etm.2024.12490