Open Access

Eukaryotic translation initiation factor EIF4G1 p.Ser637Cys mutation in a family with Parkinson's disease with antecedent essential tremor

  • Authors:
    • Rui-Han Liu
    • Xiang-Yu Xiao
    • Lei Yao
    • Yuan-Yuan Jia
    • Jia Guo
    • Xing-Chen Wang
    • Yu Kong
    • Qing-Xia Kong
  • View Affiliations

  • Published online on: March 19, 2024     https://doi.org/10.3892/etm.2024.12494
  • Article Number: 206
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Essential tremor (ET) and Parkinson's disease (PD) are common chronic movement disorders that can cause a substantial degree of disability. However, the etiology underlying these two conditions remains poorly understood. In the present study, Whole‑exome sequencing of peripheral blood samples from the proband and Sanger sequencing of the other 18 family members, and pedigree analysis of four generations of 29 individuals with both ET and PD in a nonconsanguineous Chinese family were performed. Specifically, family members who had available medical information, including historical documentation and physical examination records, were included. A novel c.1909A>T (p.Ser637Cys) missense mutation was identified in the eukaryotic translation initiation factor 4γ1 (EIF4G1) gene as the candidate likely responsible for both conditions. In total, 9 family members exhibited tremor of the bilateral upper limbs and/or head starting from ages of ≥40 years, 3 of whom began showing evidence of PD in their 70s. Eukaryotic initiation factor 4 (eIF4)G1, a component of the translation initiation complex eIF4F, serves as a scaffold protein that interacts with many initiation factors and then binds to the 40S ribosomal subunit. The EIF4G1 (p.Ser637Cys) might  inhibit the recruitment of the mRNA to the ribosome. In conclusion, the results from the present study suggested that EIF4G1 may be responsible for the hereditary PD with ‘antecedent ET’ reported in the family assessed.
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May-2024
Volume 27 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu R, Xiao X, Yao L, Jia Y, Guo J, Wang X, Kong Y and Kong Q: Eukaryotic translation initiation factor <em>EIF4G1</em> p.Ser637Cys mutation in a family with Parkinson's disease with antecedent essential tremor. Exp Ther Med 27: 206, 2024.
APA
Liu, R., Xiao, X., Yao, L., Jia, Y., Guo, J., Wang, X. ... Kong, Q. (2024). Eukaryotic translation initiation factor <em>EIF4G1</em> p.Ser637Cys mutation in a family with Parkinson's disease with antecedent essential tremor. Experimental and Therapeutic Medicine, 27, 206. https://doi.org/10.3892/etm.2024.12494
MLA
Liu, R., Xiao, X., Yao, L., Jia, Y., Guo, J., Wang, X., Kong, Y., Kong, Q."Eukaryotic translation initiation factor <em>EIF4G1</em> p.Ser637Cys mutation in a family with Parkinson's disease with antecedent essential tremor". Experimental and Therapeutic Medicine 27.5 (2024): 206.
Chicago
Liu, R., Xiao, X., Yao, L., Jia, Y., Guo, J., Wang, X., Kong, Y., Kong, Q."Eukaryotic translation initiation factor <em>EIF4G1</em> p.Ser637Cys mutation in a family with Parkinson's disease with antecedent essential tremor". Experimental and Therapeutic Medicine 27, no. 5 (2024): 206. https://doi.org/10.3892/etm.2024.12494