Squamous papilloma involving the mandible: A case report and descriptive literature review

Zheng,Xin; Liu,Lianlian; Cao,Congyuan; Huang,Shuojin; Tang,Dongxiao; Li,Shuai; He,Qianting

doi:10.3892/etm.2024.12590

Squamous papilloma involving the mandible: A case report and descriptive literature review

Authors:
- Xin Zheng
- Lianlian Liu
- Congyuan Cao
- Shuojin Huang
- Dongxiao Tang
- Shuai Li
- Qianting He
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Affiliations: Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Oral and Maxillofacial Surgery, College of Stomatology, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
Published online on: May 28, 2024 https://doi.org/10.3892/etm.2024.12590
Article Number: 301
Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Squamous papilloma is a benign neoplasm that originates from the stratified squamous epithelium of the mucous membrane. Its principal etiological factor is human papillomavirus infection, with a predilection for manifesting within the oral cavity. Squamous papilloma predominantly affects regions on the palate, cheeks, lips and tongue. However, to the best of our knowledge, the occurrence of squamous papilloma within the confines of the mandible remains unreported hitherto. The present report documents a case of squamous papilloma involving the mandible who was managed at the First Affiliated Hospital of Sun Yat‑sen University (Guangzhou, China) in January 2023. The patient underwent a series of recurrent jaw inflammations, manifesting with malignant imaging characteristics. Subsequent pathological analysis confirmed a diagnosis of papilloma in the jaw. The present report highlights the pivotal role of prolonged inflammation in the genesis of jaw squamous papilloma, prompting avenues for further investigation, including the potential of inflammation to induce aberrant cell growth, mediate cell interactions, orchestrate cytokine actions and influence stress mediators. In addition, the current study posits a plausible connection between persistent inflammation, compromised epithelial integrity and an increased likelihood of head and neck papilloma, particularly concerning human papillomavirus infection. This article delineates the clinical attributes of the uncommon manifestations of jaw papilloma and delves into the associated mechanisms, thereby contributing to an enhanced comprehension of jaw disorders. This comprehensive insight equips clinicians with a heightened knowledge base for more precise diagnosis and treatment of analogous cases.

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