Open Access

Potential clinical applications of current and future oral forms of desmopressin (Review)

  • Authors:
    • Karel Everaert
    • Tove Holm‑Larsen
    • George Bou Kheir
    • Sylvie Rottey
    • Jeffrey P. Weiss
    • Johan Vande Walle
    • Abdo E. Kabarriti
    • Lien Dossche
    • François Hervé
    • Anne-Françoise Spinoit
    • Jens Peter Nørgaard
    • Kristian Vinter Juul
  • View Affiliations

  • Published online on: May 29, 2024     https://doi.org/10.3892/etm.2024.12592
  • Article Number: 303
  • Copyright: © Everaert et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Desmopressin is a synthetic analogue of vasopressin and a selective vasopressin receptor 2 agonist. It was first synthesised in 1967 and utilised for its antidiuretic properties. It is also used in bleeding disorders to enhance clotting. Other potential uses of the drug have been reported. The present review aims to provide a broad overview of the literature on potential further uses of oral forms of desmopressin. Key therapeutic areas of interest were identified based on known physiological activities/targets of desmopressin or reports of an effect of desmopressin in the literature. The feasibility of adequate dosing with oral forms of the drug was also considered. Systematic literature searches were carried out using the silvi.ai software for the identified areas, and summaries of available papers were included in tables and discussed. The results of the searches showed that desmopressin has been investigated for its efficacy in a number of areas, including bleeding control, renal colic, the central nervous system and oncology. Evidence suggests that oral desmopressin may have the potential to be of clinical benefit for renal colic and bleeding control in particular. However, further research is needed to clarify its effect in these areas, including randomised controlled studies and studies specifically of oral formulations (and doses). Further research may also yield findings for cancer, cognition and overactive bladder.
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August-2024
Volume 28 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Everaert K, Holm‑Larsen T, Bou Kheir G, Rottey S, Weiss JP, Vande Walle J, Kabarriti AE, Dossche L, Hervé F, Spinoit A, Spinoit A, et al: Potential clinical applications of current and future oral forms of desmopressin (Review). Exp Ther Med 28: 303, 2024
APA
Everaert, K., Holm‑Larsen, T., Bou Kheir, G., Rottey, S., Weiss, J.P., Vande Walle, J. ... Juul, K.V. (2024). Potential clinical applications of current and future oral forms of desmopressin (Review). Experimental and Therapeutic Medicine, 28, 303. https://doi.org/10.3892/etm.2024.12592
MLA
Everaert, K., Holm‑Larsen, T., Bou Kheir, G., Rottey, S., Weiss, J. P., Vande Walle, J., Kabarriti, A. E., Dossche, L., Hervé, F., Spinoit, A., Nørgaard, J., Juul, K. V."Potential clinical applications of current and future oral forms of desmopressin (Review)". Experimental and Therapeutic Medicine 28.2 (2024): 303.
Chicago
Everaert, K., Holm‑Larsen, T., Bou Kheir, G., Rottey, S., Weiss, J. P., Vande Walle, J., Kabarriti, A. E., Dossche, L., Hervé, F., Spinoit, A., Nørgaard, J., Juul, K. V."Potential clinical applications of current and future oral forms of desmopressin (Review)". Experimental and Therapeutic Medicine 28, no. 2 (2024): 303. https://doi.org/10.3892/etm.2024.12592