Myopericytoma/myofibroma as a stromal component of mixed epithelial and stromal tumor of the kidney: A case report

Nikolić,Gorana; Nikolić,Gorana; Simić,Ljubica; Simić,Ljubica; Životić,Maja; Životić,Maja; Stefanović,Jelena; Stefanović,Jelena; Mioljević,Ana; Mioljević,Ana; Ćuković,Ljubica; Ćuković,Ljubica; Mijajlović,Vladimir; Mijajlović,Vladimir; Jovanović,Milena; Jovanović,Milena; Jevtić,Jovan; Jevtić,Jovan; Škodrić,Sanja Radojević; Škodrić,Sanja Radojević

doi:10.3892/etm.2024.12610

Myopericytoma/myofibroma as a stromal component of mixed epithelial and stromal tumor of the kidney: A case report

Authors:
- Gorana Nikolić
- Ljubica Simić
- Maja Životić
- Jelena Stefanović
- Ana Mioljević
- Ljubica Ćuković
- Vladimir Mijajlović
- Milena Jovanović
- Jovan Jevtić
- Sanja Radojević Škodrić
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Affiliations: Institute of Pathology ‘Dr Đorđe Joannović’, Faculty of Medicine, University of Belgrade, Belgrade 11000, Republic of Serbia, Department of Histopathology, University Clinical Centre of Serbia, Belgrade 11000, Republic of Serbia
Published online on: June 17, 2024 https://doi.org/10.3892/etm.2024.12610
Article Number: 322
Copyright: © Nikolić et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Mixed epithelial and stromal tumors (MESTs) of the kidney are rare renal neoplasms, primarily affecting middle‑aged women. These tumors are characterized by a mix of epithelial and stromal components. While generally benign, MESTs require accurate diagnosis and appropriate management due to the potential for malignant transformation. The present study reports the case of a 75‑year‑old male patient who underwent a partial nephrectomy following the incidental discovery of a kidney tumor. Histopathological examination revealed a partially cystic tumor with solid areas, measuring 26 mm in diameter. The tumor had cysts lined with cuboidal cells and an ovarian‑like stroma. The solid component consisted of elongated cells with eosinophilic cytoplasm and oval nuclei, showing angiocentric growth around small blood vessels without nuclear atypia or mitoses. Since the morphology of the solid component could not reveal the differentiation of those cells, immunohistochemical staining was performed and a myopericytoma/myofibroma component was established, mostly based on the positivity of smooth muscle actin, muscle‑specific actin, h‑caldesmon, estrogen receptor, progesterone receptor, solute carrier family 2 facilitated glucose transporter member 1 and collagen IV, along with a lack of staining for desmin, CD34, CD31 and CD99. Thus, to the best of our knowledge, for the first time in the literature, MEST with myopericytoma/myofibroma stromal component in a male patient was reported.

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