Open Access

New insights on the link between Epstein‑Barr virus infection and cognitive decline in neurodegenerative diseases (Review)

  • Authors:
    • Thomas Gabriel Schreiner
    • Constantin Romanescu
    • Oliver Daniel Schreiner
    • Farai Nhambasora
  • View Affiliations

  • Published online on: August 30, 2024     https://doi.org/10.3892/etm.2024.12702
  • Article Number: 413
  • Copyright: © Schreiner et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cognitive decline is a frequent complaint in healthy controls and neurological patients, regardless of the underlying pathology. Whilst cognitive impairment can be easily diagnosed in the more advanced stages of neurodegenerative diseases, early detection can be challenging. This is mainly the consequence of the incomplete understanding of the underlying pathophysiological mechanisms. In addition, currently available neurological treatments do not specifically target cognitive decline, since other motor and non‑motor symptoms, such as bradykinesia, tremor, autonomic disturbances and depression, are of greater relevance from a therapeutic perspective. In this context, prospective studies must address a number of issues, including the risk factors associated with cognitive deficits in neurodegenerative diseases. The present review aims to offer a novel perspective on the association between Epstein‑Barr virus infection and cognitive decline found in patients with neurodegenerative disorders. Specifically, relevant epidemiological studies and clinical trials explaining this connection were reviewed, focusing on the most frequent neurodegenerative disorders. They are namely Alzheimer's disease, Parkinson's disease and multiple sclerosis. Despite their limitations, possible underlying pathophysiological mechanisms that explain the impact of Epstein‑Barr virus infection on cognitive decline are expected to offer novel study directions on this clinically relevant topic.
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November-2024
Volume 28 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Schreiner TG, Romanescu C, Schreiner OD and Nhambasora F: New insights on the link between Epstein‑Barr virus infection and cognitive decline in neurodegenerative diseases (Review). Exp Ther Med 28: 413, 2024.
APA
Schreiner, T.G., Romanescu, C., Schreiner, O.D., & Nhambasora, F. (2024). New insights on the link between Epstein‑Barr virus infection and cognitive decline in neurodegenerative diseases (Review). Experimental and Therapeutic Medicine, 28, 413. https://doi.org/10.3892/etm.2024.12702
MLA
Schreiner, T. G., Romanescu, C., Schreiner, O. D., Nhambasora, F."New insights on the link between Epstein‑Barr virus infection and cognitive decline in neurodegenerative diseases (Review)". Experimental and Therapeutic Medicine 28.5 (2024): 413.
Chicago
Schreiner, T. G., Romanescu, C., Schreiner, O. D., Nhambasora, F."New insights on the link between Epstein‑Barr virus infection and cognitive decline in neurodegenerative diseases (Review)". Experimental and Therapeutic Medicine 28, no. 5 (2024): 413. https://doi.org/10.3892/etm.2024.12702