In the present case, a 66‑year‑old woman presented to the Specialty Hospital (Amman, Jordan) with recurrent post‑menopausal bleeding. A pelvic ultrasound scan showed an abnormal endometrial thickness of 8 mm and no adnexal masses. An endometrial biopsy revealed abundant foamy histiocyte infiltration features suggestive of xanthogranulomatous endometritis. Subsequently, a total abdominal hysterectomy and bilateral salpingo‑oophorectomy were performed, before histopathology confirmed the co‑existence of uterine malakoplakia (MP) and Rosai‑Dorfman disease (RDD). The patient had recurrent admissions for abscess drainage and pneumonia. MP and RDD of the uterus are both rare inflammatory diseases characterized by the histiocytic infiltration of the endometrium, which can occasionally be misdiagnosed as cancer and associated with an increased risk of systemic infections. The present case report shows that surgical resection provides a definite diagnosis and treatment guidance of this disease, potentially reducing the inflammatory process and recurrence rate. To the best of our knowledge, the present case report was the first of the coexistence of uterine RDD and MP.

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