Role of inhibitor of DNA binding-1 protein is related to angiogenesis in the tumor advancement of uterine endometrial cancers

Maw,Min K.; Fujimoto,Jiro; Tamaya,Teruhiko

doi:10.3892/etm_00000055

Role of inhibitor of DNA binding-1 protein is related to angiogenesis in the tumor advancement of uterine endometrial cancers

Authors:
- Min K. Maw
- Jiro Fujimoto
- Teruhiko Tamaya
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Affiliations: Department of Obstetrics and Gynecology, Graduate School of Medicine, Gifu University School of Medicine, Gifu 501-1194, Japan
Published online on: March 1, 2010 https://doi.org/10.3892/etm_00000055
Pages: 351-356

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Abstract

The inhibitor of DNA binding (ID)-1 protein, an inhibitor of basic helix-loop-helix transcription factors, has been found to be involved in multiple cellular functions. In the present study, ID-1 histoscores and mRNA levels were both significantly (p<0.05) increased in uterine endometrial cancers according to clinical stage, histological grade and depth of myometrial invasion. Furthermore, the 60-month survival rate of the 25 patients with high ID-1 was poor (52%), while that of the other 25 patients with low ID-1 was significantly higher (80%) (p<0.05). ID-1 histoscores and mRNA levels significantly (p<0.0001) correlated with microvessel counts in uterine endometrial cancers. Therefore, ID-1 acts on tumor advancement via angiogenic activity and can be considered a candidate prognostic indicator in uterine endometrial cancers.

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