Epigenetic activation of E-cadherin is a candidate therapeutic target in human hepatocellular carcinoma

  • Authors:
    • Xuemei Qiu
    • Fengchang Qiao
    • Xianwei Su
    • Zhujiang Zhao
    • Hong Fan
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  • Published online on: May 1, 2010     https://doi.org/10.3892/etm_00000082
  • Pages: 519-523
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Abstract

E-cadherin is a key cell adhesion molecule implicated in tumor suppression that is frequently altered in hepatocellular carcinoma (HCC), particularly in hepatitis B virus-related tumors. Here, we report that the epigenetic drugs 5-azacytidine and trichostatin A up-regulated E-cadherin expression in HCC cells. The depletion of DNMT1 restored E-cadherin expression via demethylation, whereas the depletion of DNMT3A or DNMT3B did not. Activated E-cadherin suppressed HCC cell colony formation. However, E-cadherin expression was repressed by HBx transfection due to the DNA methylation induced by the elevation of DNMT1 in the HCC cell lines. The present study indicates that E-cadherin expression is regulated by epigenetic agents in HCC cells, which suggests a schema for restoring E-cadherin by targeting its epigenetic mechanism.
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May-June 2010
Volume 1 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Qiu X, Qiao F, Su X, Zhao Z and Fan H: Epigenetic activation of E-cadherin is a candidate therapeutic target in human hepatocellular carcinoma . Exp Ther Med 1: 519-523, 2010.
APA
Qiu, X., Qiao, F., Su, X., Zhao, Z., & Fan, H. (2010). Epigenetic activation of E-cadherin is a candidate therapeutic target in human hepatocellular carcinoma . Experimental and Therapeutic Medicine, 1, 519-523. https://doi.org/10.3892/etm_00000082
MLA
Qiu, X., Qiao, F., Su, X., Zhao, Z., Fan, H."Epigenetic activation of E-cadherin is a candidate therapeutic target in human hepatocellular carcinoma ". Experimental and Therapeutic Medicine 1.3 (2010): 519-523.
Chicago
Qiu, X., Qiao, F., Su, X., Zhao, Z., Fan, H."Epigenetic activation of E-cadherin is a candidate therapeutic target in human hepatocellular carcinoma ". Experimental and Therapeutic Medicine 1, no. 3 (2010): 519-523. https://doi.org/10.3892/etm_00000082