Open Access

Experimental models and plant‑based therapy for experimental cerebral ischemia (Review)

  • Authors:
    • Nada M. Ezzelarab
    • Naela Saleh
    • Eman A. Khalil
    • Ahmed Abdellatif
  • View Affiliations

  • Published online on: August 11, 2020     https://doi.org/10.3892/ijfn.2020.5
  • Article Number: 5
  • Copyright: © Ezzelarab et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cerebral ischemia is a leading cause of mortality worldwide. Available treatments are mainly thrombolytic agents for restoring blood flow to the brain. However, this approach has a very narrow treatment window. Despite extensive research, there is still a need for further investigations to identify and develop novel treatment approaches. The present review aimed to summarize and discuss evidence from the literature regarding the best models with which to study cerebral ischemia and the available herbal sources that may provide potential treatment strategies for cerebral ischemia. The present review was based on research published between 1990 and 2020. Herbal remedies provide a promising research area that warrants further attention from researchers in the field. Different models have been used to investigate the pathophysiology of cerebral ischemia/reperfusion, and to examine various treatment approaches. The plant kingdom is rich in various phytochemicals with neuroprotective functions. From the literature search performed herein, it can be concluded that middle cerebral and bilateral common carotid artery occlusion models are the most convenient, cost‑effective and easily reproducible models. A number of plants, particularly those from Southeast Asia, have used for cerebral ischemia research; however, many more need to be investigated, particularly plants from Africa.
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September-October 2020
Volume 1 Issue 1

Print ISSN: 2634-7989
Online ISSN:2634-7237

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Spandidos Publications style
Ezzelarab NM, Saleh N, Khalil EA and Abdellatif A: Experimental models and plant‑based therapy for experimental cerebral ischemia (Review). Int J Funct Nutr 1: 5, 2020.
APA
Ezzelarab, N.M., Saleh, N., Khalil, E.A., & Abdellatif, A. (2020). Experimental models and plant‑based therapy for experimental cerebral ischemia (Review). International Journal of Functional Nutrition, 1, 5. https://doi.org/10.3892/ijfn.2020.5
MLA
Ezzelarab, N. M., Saleh, N., Khalil, E. A., Abdellatif, A."Experimental models and plant‑based therapy for experimental cerebral ischemia (Review)". International Journal of Functional Nutrition 1.1 (2020): 5.
Chicago
Ezzelarab, N. M., Saleh, N., Khalil, E. A., Abdellatif, A."Experimental models and plant‑based therapy for experimental cerebral ischemia (Review)". International Journal of Functional Nutrition 1, no. 1 (2020): 5. https://doi.org/10.3892/ijfn.2020.5