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Biological effects of grape stem extracts on human cancer cell lines

  • Authors:
    • Eleni Vassi
    • Aristidis S. Veskoukis
    • Fotios Tekos
    • Zoi Skaperda
    • Konstantinos Poulas
    • Serkos Haroutounian
    • Demetrios Kouretas
  • View Affiliations

  • Published online on: May 4, 2022     https://doi.org/10.3892/ijfn.2022.27
  • Article Number: 4
  • Copyright: © Vassi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Grapes are rich in polyphenolic compounds, which are known for their beneficial effects on human health. Grape stems are byproducts of the winemaking procedure. They exert antioxidant effects; however, they can also become pollutants when discarded without control into the environment due to their high organic content. The main aim of the present study was to examine the potential prooxidant/anticancer effects of grape stem extracts, promoting the rationale of the scientific exploitation of such compounds. Therefore, three grape stem extracts derived from the native Greek vine varieties, Mavrodaphne, Muscat and Rhoditis were examined for their ability to alter the redox status [i.e., endogenous levels of reduced glutathione and reactive oxygen species (ROS)] of HeLa and HepG2 human cancer cell lines. The results revealed that the extracts from Muscat and Rhoditis exerted prooxidant effects on the tested cell lines, whereas the extract of Mavrodaphne did not exert any such effects. The fact that the extracts functioned as prooxidants appears to be detrimental for the cancer cells, since they are more susceptible to high concentrations of ROS, contrary to healthy cells that possess more robust antioxidant defense mechanisms. On the whole, as demonstrated in the present study, it appears that the Muscat and Rhoditis extracts may prove to be promising agents against cancer cells in the specific in vitro model. However, further studies are required to confirm these findings, in in vivo settings.
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Spandidos Publications style
Vassi E, Veskoukis AS, Tekos F, Skaperda Z, Poulas K, Haroutounian S and Kouretas D: Biological effects of grape stem extracts on human cancer cell lines. Int J Funct Nutr 3: 4, 2022.
APA
Vassi, E., Veskoukis, A.S., Tekos, F., Skaperda, Z., Poulas, K., Haroutounian, S., & Kouretas, D. (2022). Biological effects of grape stem extracts on human cancer cell lines. International Journal of Functional Nutrition, 3, 4. https://doi.org/10.3892/ijfn.2022.27
MLA
Vassi, E., Veskoukis, A. S., Tekos, F., Skaperda, Z., Poulas, K., Haroutounian, S., Kouretas, D."Biological effects of grape stem extracts on human cancer cell lines". International Journal of Functional Nutrition 3.3 (2022): 4.
Chicago
Vassi, E., Veskoukis, A. S., Tekos, F., Skaperda, Z., Poulas, K., Haroutounian, S., Kouretas, D."Biological effects of grape stem extracts on human cancer cell lines". International Journal of Functional Nutrition 3, no. 3 (2022): 4. https://doi.org/10.3892/ijfn.2022.27