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AZT side effect on mitochondria does not depend on either inhibition of electron flow or mitochondrial uncoupling.

  • Authors:
    • A Atlante
    • S Passarella

  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/ijmm.1.3.601
  • Pages: 601-604
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The mitochondrial myopathy associated with long-term AZT therapy limits the clinical efficacy of this drug in AIDS therapy. Thus, in order to determine how AZT can affect mitochondria bioenergetics, the capability of AZT to both uncouple oxidative phosphorylation and inhibit electron flow in isolated rat liver mitochondria was investigated. The failure of AZT to oxidize intramitochondrial pyridine nucleotides, to stimulate mitochondrial swelling in K+-acetate plus valinomycin or to cause ATP hydrolysis shows that AZT is not an uncoupler.

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Mar 1998
Volume 1 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Atlante A and Passarella S: AZT side effect on mitochondria does not depend on either inhibition of electron flow or mitochondrial uncoupling.. Int J Mol Med 1: 601-604, 1998.
APA
Atlante, A., & Passarella, S. (1998). AZT side effect on mitochondria does not depend on either inhibition of electron flow or mitochondrial uncoupling.. International Journal of Molecular Medicine, 1, 601-604. https://doi.org/10.3892/ijmm.1.3.601
MLA
Atlante, A., Passarella, S."AZT side effect on mitochondria does not depend on either inhibition of electron flow or mitochondrial uncoupling.". International Journal of Molecular Medicine 1.3 (1998): 601-604.
Chicago
Atlante, A., Passarella, S."AZT side effect on mitochondria does not depend on either inhibition of electron flow or mitochondrial uncoupling.". International Journal of Molecular Medicine 1, no. 3 (1998): 601-604. https://doi.org/10.3892/ijmm.1.3.601