Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis

  • Authors:
    • Kosuke Tobita
    • Hiroshi Kijima
    • Shoichi Dowaki
    • Hiroyuki Kashiwagi
    • Yasuo Ohtani
    • Yasuhisa Oida
    • Hitoshi Yamazaki
    • Masato Nakamura
    • Yoshito Ueyama
    • Makiko Tanaka
    • Sadaki Inokuchi
    • Hiroyasu Makuuchi
  • View Affiliations

  • Published online on: March 1, 2003     https://doi.org/10.3892/ijmm.11.3.305
  • Pages: 305-309
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Abstract

Pancreatic cancer is a malignant tumor with an extremely poor prognosis. The mechanisms of the aggressive growth and metastasis are not yet extensively understood. Over-expression of epidermal growth factor receptor (EGFR) was suggested to be associated with malignant transformation of pancreatic cancer. We examined EGFR expression in 77 cases of invasive ductal adenocarcinoma of the pancreas, and analyzed the relation between the EGFR expression pattern and clinicopathological factors. EGFR immunoreactivity was detected in 41.6% (32/77) of human pancreatic cancers; i.e. diffuse expression in 32.5% (25/77) and focal expression in 9.1% (7/77). The EGFR expression was associated with gender (p<0.05), histological differentiation (p<0.05) and metastatic status of TNM classification (p<0.01). The observations suggested that EGFR expression plays important roles in metastasis, especially liver metastasis and recurrence of human pancreatic cancer.

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March 2003
Volume 11 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Tobita K, Kijima H, Dowaki S, Kashiwagi H, Ohtani Y, Oida Y, Yamazaki H, Nakamura M, Ueyama Y, Tanaka M, Tanaka M, et al: Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis. Int J Mol Med 11: 305-309, 2003.
APA
Tobita, K., Kijima, H., Dowaki, S., Kashiwagi, H., Ohtani, Y., Oida, Y. ... Makuuchi, H. (2003). Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis. International Journal of Molecular Medicine, 11, 305-309. https://doi.org/10.3892/ijmm.11.3.305
MLA
Tobita, K., Kijima, H., Dowaki, S., Kashiwagi, H., Ohtani, Y., Oida, Y., Yamazaki, H., Nakamura, M., Ueyama, Y., Tanaka, M., Inokuchi, S., Makuuchi, H."Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis". International Journal of Molecular Medicine 11.3 (2003): 305-309.
Chicago
Tobita, K., Kijima, H., Dowaki, S., Kashiwagi, H., Ohtani, Y., Oida, Y., Yamazaki, H., Nakamura, M., Ueyama, Y., Tanaka, M., Inokuchi, S., Makuuchi, H."Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis". International Journal of Molecular Medicine 11, no. 3 (2003): 305-309. https://doi.org/10.3892/ijmm.11.3.305