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Intracerebroventricular administration of NPY stimulates resistin gene expression in mice

  • Authors:
    • Hideki Yuzuriha
    • Akio Inui
    • Kyoko Goto
    • Akihiro Asakawa
    • Mineko Fujimiya
    • Masato Kasuga

  • View Affiliations

  • Published online on: May 1, 2003     https://doi.org/10.3892/ijmm.11.5.675
  • Pages: 675-676
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Abstract

Resistin is thought to cause insulin resistance and link obesity to type 2 diabetes mellitus. However, little is known about the effects of neuropeptide Y (NPY) on resistin gene expression in white adipose tissue (WAT). Resistin gene expression was determined by northern blot analysis in food-deprived mice after NPY administration. Administered NPY (1 nmol/mouse) significantly increased resistin mRNA expression in WAT by 72% compared with artificial cerebrospinal fluid treated controls. These observations indicate that NPY might have a role in regulating resistin gene expression in WAT and that the novel brain-fat axis might be involved in the pathogenesis of obesity and related diseases.

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Journal Cover

May 2003
Volume 11 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Yuzuriha H, Inui A, Goto K, Asakawa A, Fujimiya M and Kasuga M: Intracerebroventricular administration of NPY stimulates resistin gene expression in mice. Int J Mol Med 11: 675-676, 2003.
APA
Yuzuriha, H., Inui, A., Goto, K., Asakawa, A., Fujimiya, M., & Kasuga, M. (2003). Intracerebroventricular administration of NPY stimulates resistin gene expression in mice. International Journal of Molecular Medicine, 11, 675-676. https://doi.org/10.3892/ijmm.11.5.675
MLA
Yuzuriha, H., Inui, A., Goto, K., Asakawa, A., Fujimiya, M., Kasuga, M."Intracerebroventricular administration of NPY stimulates resistin gene expression in mice". International Journal of Molecular Medicine 11.5 (2003): 675-676.
Chicago
Yuzuriha, H., Inui, A., Goto, K., Asakawa, A., Fujimiya, M., Kasuga, M."Intracerebroventricular administration of NPY stimulates resistin gene expression in mice". International Journal of Molecular Medicine 11, no. 5 (2003): 675-676. https://doi.org/10.3892/ijmm.11.5.675