EGF mediates multiple signals: dependence on the conditions

  • Authors:
    • Angela R. Kamer
    • Peter G. Sacks
    • Adrian Vladutiu
    • Charles Liebow
  • View Affiliations

  • Published online on: January 1, 2004     https://doi.org/10.3892/ijmm.13.1.143
  • Pages: 143-147
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Abstract

Epidermal growth factor (EGF) has been reported to both increase and decrease proliferation and apoptosis. In KB cells, EGF-induced alteration in proliferation and apoptosis are concentration and time dependent. High concentrations of EGF (10−7 and 10−8 M) stimulated proliferation and inhibited apoptosis at 24 h, with apoptosis increasing with prolonged exposure. Low concentrations of EGF (10−10-10−11 M) inhibited apoptosis without affecting proliferation. EGFR protein expression was downregulated at high and upregulated at low EGF concentrations. Significant inverse correlation was shown between EGFR expression level and apoptosis. These results suggest the EGF receptor involvement in the modulation of apoptosis and the role of EGF anti-apoptotic effects in EGF-induced apoptosis.

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January 2004
Volume 13 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kamer AR, Sacks PG, Vladutiu A and Liebow C: EGF mediates multiple signals: dependence on the conditions. Int J Mol Med 13: 143-147, 2004.
APA
Kamer, A.R., Sacks, P.G., Vladutiu, A., & Liebow, C. (2004). EGF mediates multiple signals: dependence on the conditions. International Journal of Molecular Medicine, 13, 143-147. https://doi.org/10.3892/ijmm.13.1.143
MLA
Kamer, A. R., Sacks, P. G., Vladutiu, A., Liebow, C."EGF mediates multiple signals: dependence on the conditions". International Journal of Molecular Medicine 13.1 (2004): 143-147.
Chicago
Kamer, A. R., Sacks, P. G., Vladutiu, A., Liebow, C."EGF mediates multiple signals: dependence on the conditions". International Journal of Molecular Medicine 13, no. 1 (2004): 143-147. https://doi.org/10.3892/ijmm.13.1.143