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Growth hormone secretagogue receptor subtypes 1a and 1b are expressed in the human adrenal cortex

  • Authors:
    • Gianni Carraro
    • Giovanna Albertin
    • Abudujilili Abudukerimu
    • Francesco Aragona
    • Gastone G. Nussdorfer

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  • Published online on: February 1, 2004     https://doi.org/10.3892/ijmm.13.2.295
  • Pages: 295-298
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Abstract

Ghrelin is an endogenous ligand of the growth hormone secretagogue receptors (GHS-Rs), two subtypes of which have been recognized: the biologically active 1a and the biologically inactive 1b subtype. Reverse transcription-polymerase chain reaction demonstrated ghrelin and GHS-R1b mRNAs in eight human adrenal cortexes, and GHS-R1a mRNA only in six of the eight adrenal specimens. The GHS-R1a expression was absent in the two adrenal cortexes obtained from 76- and 79-year old male patients. Since previous studies showed that ghrelin does not affect steroid-hormone secretion, the present findings suggest that ghrelin via the GHS-R1a could be involved in the autocrine-paracrine control of human-adrenal growth.

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Journal Cover

February 2004
Volume 13 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Carraro G, Albertin G, Abudukerimu A, Aragona F and Nussdorfer GG: Growth hormone secretagogue receptor subtypes 1a and 1b are expressed in the human adrenal cortex. Int J Mol Med 13: 295-298, 2004.
APA
Carraro, G., Albertin, G., Abudukerimu, A., Aragona, F., & Nussdorfer, G.G. (2004). Growth hormone secretagogue receptor subtypes 1a and 1b are expressed in the human adrenal cortex. International Journal of Molecular Medicine, 13, 295-298. https://doi.org/10.3892/ijmm.13.2.295
MLA
Carraro, G., Albertin, G., Abudukerimu, A., Aragona, F., Nussdorfer, G. G."Growth hormone secretagogue receptor subtypes 1a and 1b are expressed in the human adrenal cortex". International Journal of Molecular Medicine 13.2 (2004): 295-298.
Chicago
Carraro, G., Albertin, G., Abudukerimu, A., Aragona, F., Nussdorfer, G. G."Growth hormone secretagogue receptor subtypes 1a and 1b are expressed in the human adrenal cortex". International Journal of Molecular Medicine 13, no. 2 (2004): 295-298. https://doi.org/10.3892/ijmm.13.2.295